Patents Assigned to Sugen Incorporated
  • Mammalian protein phosphatases
    Publication number: 20040157306
    Abstract: The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.
    Type: Application
    Filed: November 20, 2003
    Publication date: August 12, 2004
    Applicant: SUGEN INCORPORATED
    Inventors: Gregory D. Plowman, David Whyte, Gerard Manning
  • Mammalian protein phosphatases
    Publication number: 20040132155
    Abstract: The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.
    Type: Application
    Filed: November 20, 2003
    Publication date: July 8, 2004
    Applicant: SUGEN INCORPORATED
    Inventors: Gregory D. Plowman, David Whyte, Gerard Manning
  • Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
    Patent number: 6710067
    Abstract: The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: March 23, 2004
    Assignees: Sugen Incorporated, Pharmacia & UpJohn Company
    Inventors: Malcolm Wilson Moon, Walter Morozowich, Ping Gao, Peng Cho Tang
  • Pharmaceutical formulations comprising indolinone derivatives
    Publication number: 20030176399
    Abstract: The present invention is directed to formulations comprising 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Methods of treating diseases related to abnormal PK activity utilizing the formulations comprising these compounds and methods of making these formulations are also disclosed.
    Type: Application
    Filed: November 21, 2002
    Publication date: September 18, 2003
    Applicant: SUGEN INCORPORATED
    Inventors: Ping Gao, Anand Sistla, Narmada Shenoy
  • Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
    Publication number: 20030083363
    Abstract: The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Application
    Filed: September 16, 2002
    Publication date: May 1, 2003
    Applicant: SUGEN INCORPORATED
    Inventors: Malcolm Wilson Moon, Walter Morozowich, Ping Gao, Marcel Koenig
  • Novel human protein phosphatases identified from genomic sequencing
    Publication number: 20030027308
    Abstract: The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.
    Type: Application
    Filed: November 13, 2001
    Publication date: February 6, 2003
    Applicant: SUGEN INCORPORATED
    Inventors: Gregory D. Plowman, David Whyte, Gerard Manning
  • Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
    Patent number: 6482848
    Abstract: The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: November 19, 2002
    Assignee: Sugen Incorporated
    Inventors: Malcolm Wilson Moon, Walter Morozowich, Ping Gao, Marcel Koenig