Patents Assigned to SUMITOMO PHARMA CO., LTD.
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Publication number: 20240150807Abstract: A method for producing a cysteine knot protein, the method including: producing the cysteine knot protein by culturing a transformed mammalian cell containing a gene encoding the cysteine knot protein and a gene encoding an exogenous chaperone protein in a protein production medium; and collecting the produced cysteine knot protein, wherein the chaperone protein includes one or more selected from the group consisting of HSP90?, HSP90?, CDC37, HSP70, HSP40, HSP60, HSP10, HSP110, and HSP27.Type: ApplicationFiled: March 9, 2022Publication date: May 9, 2024Applicant: Sumitomo Pharma Co., Ltd.Inventors: Hidetaka NAGATA, WenLien LIN, Reiko ASADA, Kenji TAKIKAWA
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Publication number: 20240148296Abstract: Systems, methods, and devices for implementing cognitive behavioral therapy to help a subject to manage a psychiatric or mental condition of the subject are provided. Interactive digital reality (DR) activities are provided through an interactive DR scene, each configured for a subject to practice a specific reframing technique. In some embodiments, a method also includes providing one or more additional psychotherapeutic or psychoeducational techniques. Through the practice of satisfying conditions associated with each interactive DR activity, the systems, methods, and devices help a subject to manage a psychiatric or mental condition of the subject, such as by getting better at recognizing and/or challenging an anxious thought as the thought occurs, and/or by reframing the anxious thought into more a different thought using the interactive DR scene.Type: ApplicationFiled: October 13, 2023Publication date: May 9, 2024Applicants: BehaVR, LLC, Sumitomo Pharma Co., Ltd.Inventors: Roward Agulto, Jillian Ahrens, Eleanor Anderson, Todd Grinnell, Robert Hayes, Shannon Hooper, Katie Howard, Marc Recasens, Bayley Taple, Risa Weisberg, Sarah Zadd, Gazeleh Vakili
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Publication number: 20240148727Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.Type: ApplicationFiled: January 12, 2024Publication date: May 9, 2024Applicant: Sumitomo Pharma Co., Ltd.Inventors: Seiji KAMIOKA, Hitoshi BAN, Naoaki SHIMADA, Wataru HIROSE, Akihiko ARAKAWA, Kazuto YAMAZAKI, Kenjiro HIRA
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Publication number: 20240150370Abstract: The present disclosure provides bicyclic pyridine derivatives. A compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein X is a oxygen atom, sulfur atom, NR, or CR?R?, n is 0 or 1, R1, R2a, R2b, R2c, R2d, R, R? and R? are each independently a hydrogen atom, a halogen atom, optionally substituted C1-6 alkyl, or an optionally substituted C6-10 aryl, or two of R2a, R2b, R2c, R2d, R, R?, and R?, together with a carbon atom or a nitrogen atom to which they are attached, form a 3- to 6-membered saturated carbocyclic ring or saturated heterocyclic ring, and R3a, R3b, R3c and R5a and R5b, are as defined in the description.Type: ApplicationFiled: November 10, 2023Publication date: May 9, 2024Applicant: Sumitomo Pharma Co., Ltd.Inventors: Satoshi ADACHI, Hidefumi YOSHINAGA, Hajime SHIBATA, Yusuke SHIODA, Riko NAGAHAMA
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Publication number: 20240143583Abstract: A system comprising a client device and a server network, the client device configured to receive a query; transmit the query; receive a populated response; and display the populated response. The server network may be configured to receive the query; tokenize the query; generate an intent-match likelihood for each of a plurality of supported question intents; classify the query based on the intent-match likelihoods; evaluate each of the intent-match likelihoods to a confidence threshold; extract, via a Named Entity Recognition model, one or more entities from the query; determine one or more entity values for each of the one or more entities; query the at least one database to incorporate intent to the one or more entities and the one or more entity values; populate a response template with the one or more entity values and one or more specifics; and store the query and the populated response.Type: ApplicationFiled: October 12, 2023Publication date: May 2, 2024Applicant: Sumitomo Pharma Co., Ltd.Inventors: Alan Jeffrey Menaged, Elliott Rain Morelli, Daniel Jaebin Park, Jonathan William Price, Daniel Benjamin Rand, Timothy Cao Tran
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Publication number: 20240124429Abstract: The present invention relates to a medicament for treating or preventing central nervous system disease whose cause is related to abnormal aggregation of proteins in the brain, which comprises as an active ingredient a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are hydrogen, etc., R3 and R4 are hydrogen, C1-6 alkyl, etc., R5 is halogen, C1-6 alkyl, etc., R6 is hydrogen, halogen, etc., X is oxygen, etc., Y is carbon, etc., m and n are an integer of 0, 1, etc., r and s are 0, 1, 2, etc., Hy is pyridine ring, etc., which has an action of suppressing or reducing the accumulation of abnormal aggregation of proteins in the brain.Type: ApplicationFiled: November 16, 2023Publication date: April 18, 2024Applicant: Sumitomo Pharma Co., Ltd.Inventors: Hitoshi WATANABE, Shuya YAMADA, Katsushi KITAHARA, Mariko KOBAYASHI
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Publication number: 20240129686Abstract: A display control apparatus for controlling display of a display device that a user can wear acquires speech collected by a plurality of microphones, estimates a sound-arrival direction of the acquired speech, and generates a text image corresponding to the acquired speech. The display control apparatus determines an adjustment amount of a display position of the text image on the display unit of the display device based on a detection result of at least one of an operation by the user and a state of the display device. Then, the display control apparatus displays the generated text image at a display position in the display unit, the display position being determined in accordance with the estimated sound-arrival direction and the determined adjustment amount.Type: ApplicationFiled: December 19, 2023Publication date: April 18, 2024Applicants: Pixie Dust Technologies, Inc., Sumitomo Pharma Co., Ltd.Inventors: Megumi TABATA, Haruki NISHIMURA, Akira ENDO, Yasuhiro HABARA, Masaki GOMI, Yudai TAIRA
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Publication number: 20240122941Abstract: The present disclosure provides a pharmaceutical composition for treating and/or preventing SWI/SNF complex-dysfunction cancer. More specifically, according to the present disclosure, a compound represented by formulae (1) to (23) (the formulae are as set forth in the specification) or a pharmaceutically acceptable salt thereof can have a therapeutic and/or prophylactic effect on SWI/SNF complex-dysfunction cancer. A pharmaceutical composition, which is for treating and/or preventing cancer and contains a CBP/P300 inhibitor, can be provided. The cancer may be SWI/SNF complex-dysfunction cancer. The SWI/SNF complex-dysfunction cancer may be BAF complex-dysfunction cancer. The BAF complex-dysfunction cancer may be SMARC-deficient cancer, ARID-deficient cancer, or SS18-SSX fusion cancer. The SMARC-deficient cancer may be SMARCB1-deficient cancer, SMARCA2-deficient cancer, SMARCA4-deficient cancer, or SMARCA2/A4-deficient cancer.Type: ApplicationFiled: December 24, 2021Publication date: April 18, 2024Applicants: NATIONAL CANCER CENTER, Sumitomo Pharma Co., Ltd.Inventors: Hideaki OGIWARA, Mariko SASAKI
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Publication number: 20240119684Abstract: A display control apparatus for controlling display of a display device acquires speech collected by a plurality of microphones and estimates a sound-arrival direction of the acquired speech. Then, the display control apparatus causes a text image corresponding to the acquired speech to be displayed in a predetermined text display area in a display unit of the display device, and causes a symbol image associated with the text image to be displayed at a display position in the display unit, the display position corresponding to the estimated sound-arrival direction.Type: ApplicationFiled: December 19, 2023Publication date: April 11, 2024Applicants: Pixie Dust Technologies, Inc., Sumitomo Pharma Co., Ltd.Inventors: Megumi TABATA, Haruki NISHIMURA, Akira ENDO, Yasuhiro HABARA, Masaki GOMI, Yudai TAIRA
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Publication number: 20240117304Abstract: A cell population comprising Corin- and/or Lrtm1-positive cells was produced by the following steps (1) and (2), from which Corin positive and/or Lrtm1 positive cells are collected using a substance that binds to Corin and/or a substance that binds to Lrtm1, and dopaminergie neuron progenitor cells are produced by performing suspension culture of the Corin positive and/or Lrtm1 positive cells in a culture solution containing one or more nutritional factors: (1) a step of performing adhesion culture of pluripotent stem cells in a medium for maintaining undifferentiated state containing a Sonic hedgehog (SHH) signal stimulant, and an undifferentiated state-maintaining factor in the absence of feeder cells but in the presence of an extracellular matrix, and (2) a step of culturing the cell population obtained in the step (1) in a culture solution containing one or more differentiation-inducing factors.Type: ApplicationFiled: December 14, 2023Publication date: April 11, 2024Applicants: KYOTO UNIVERSITY, SUMITOMO PHARMA CO., LTD.Inventors: Jun TAKAHASHI, Daisuke DOI, Kenji YOSHIDA, Atsushi KUWAHARA, Masayo TAKAHASHI
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Publication number: 20240100022Abstract: The present invention relates to an oral solid dosage form comprising N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof as an active ingredient, which has good dissolution and storage-stability. When the oral solid dosage form is a tablet, the tablet can be prepared while inhibiting tableting troubles from low content to high content of the active ingredient.Type: ApplicationFiled: December 22, 2021Publication date: March 28, 2024Applicants: SUMITOMO PHARMA CO., LTD., ALPHANAVI PHARMA INC.Inventors: Hiroki IKARI, Yuka KATO, Makoto MATSUOKA, Yasuhiro MATSUI, Megumi MARUYAMA
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Patent number: 11925621Abstract: The present invention pertains to a drug for the treatment and/or prevention of pain, more specifically to a medicinal preparation for external use to treat and/or prevent peripheral neuropathic pain, the medicinal preparation containing as an active ingredient N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide.Type: GrantFiled: July 18, 2019Date of Patent: March 12, 2024Assignee: SUMITOMO PHARMA CO., LTD.Inventors: Masayasu Tanaka, Yoshihiro Oyamada, Yoshinori Takada
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Patent number: 11911466Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: GrantFiled: January 25, 2022Date of Patent: February 27, 2024Assignee: Sumitomo Pharma Co., Ltd.Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Patent number: 11911381Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.Type: GrantFiled: May 23, 2022Date of Patent: February 27, 2024Assignee: Sumitomo Pharma Co., Ltd.Inventors: Seiji Kamioka, Hitoshi Ban, Naoaki Shimada, Wataru Hirose, Akihiko Arakawa, Kazuto Yamazaki, Kenjiro Hira
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Publication number: 20240059732Abstract: A compound represented by formula (1-1): wherein b represents an integer of 1 to 5; and Z is a group represented by formula (Z-1), formula (Z-2), formula (Z-3), formula (Za-1), formula (Za-2), formula (Za-3), formula (Za-4) or formula (Za-5), or a salt thereof.Type: ApplicationFiled: July 3, 2023Publication date: February 22, 2024Applicant: Sumitomo Pharma Co., Ltd.Inventors: Hitoshi Ban, Atsushi Suwa, Yosuke Takanashi
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Patent number: 11898163Abstract: A cell population comprising Corin- and/or Lrtm1-positive cells was produced by the following steps (1) and (2), from which Corin positive and/or Lrtm1 positive cells are collected using a substance that binds to Corin and/or a substance that binds to Lrtm1, and dopaminergic neuron progenitor cells are produced by performing suspension culture of the Corin positive and/or Lrtm1 positive cells in a culture solution containing one or more nutritional factors: (1) a step of performing adhesion culture of pluripotent stem cells in a medium for maintaining undifferentiated state containing a Sonic hedgehog (SHH) signal stimulant, and an undifferentiated state-maintaining factor in the absence of feeder cells but in the presence of an extracellular matrix, and (2) a step of culturing the cell population obtained in the step (1) in a culture solution containing one or more differentiation-inducing factors.Type: GrantFiled: April 24, 2017Date of Patent: February 13, 2024Assignees: KYOTO UNIVERSITY, SUMITOMO PHARMA CO., LTD.Inventors: Jun Takahashi, Daisuke Doi, Kenji Yoshida, Atsushi Kuwahara, Masayo Takahashi
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Publication number: 20240018516Abstract: A single-stranded antisense oligonucleotide, or a pharmaceutically acceptable salt thereof, capable of modulating expression and/or function of RPS25 gene, wherein nucleotides of the single-stranded antisense oligonucleotide are bonded to each other via a phosphate group and/or a modified phosphate group, the single-stranded antisense oligonucleotide includes a gap region, a 3? wing region bonded to a 3? end of the gap region, and a 5? wing region bonded to a 5? end of the gap region, the gap region is a deoxyribose-based nucleic acid optionally including a nucleic acid having a modified sugar moiety, each of the 3? wing region and the 5? wing region is a modified nucleotide, the single-stranded antisense oligonucleotide has a base length of 12- to 30-mer, and a base sequence of the antisense oligonucleotide is: a base sequence with a sequence identity of 90% to 100% to a base sequence complementary to at least one target region of the same base length as the antisense oligonucleotide present in the base sequType: ApplicationFiled: November 5, 2021Publication date: January 18, 2024Applicants: Sumitomo Pharma Co., Ltd., Luxna Biotech Co., Ltd.Inventors: Rika Suzuki, Shigehiro Asano, Mitsumasa Kurita, Takao Suzuki, Masaki Yamagami, Ajaya Ram Shrestha, Takaaki Kawanobe, Tadashi Umemoto
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Publication number: 20230404451Abstract: A sightline-position determination device includes: a sightline-position input unit to which a position of a sightline of a user is inputted; a determination region setting unit which sets a determination region; a determination unit which determines whether or not the position of the sightline inputted from the sightline-position input unit falls within the determination region; and an output unit which outputs feedback to the user when the determination unit has determined that the position of the sightline falls within the determination region.Type: ApplicationFiled: October 6, 2021Publication date: December 21, 2023Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, Sumitomo Pharma Co., Ltd.Inventors: Toshiya NAKAGUCHI, Eiji SHIMIZU, Yoshiyuki HIRANO, Chihiro SUTOH, Naomi SHIRAIWA, Yuki IKEDA, Shunsuke SAITO
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Patent number: D1018862Type: GrantFiled: March 7, 2022Date of Patent: March 19, 2024Assignee: Sumitomo Pharma Co., Ltd.Inventor: Sadao Masayoshi
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Patent number: D1018863Type: GrantFiled: March 7, 2022Date of Patent: March 19, 2024Assignee: Sumitomo Pharma Co., Ltd.Inventor: Sadao Masayoshi