Patents Assigned to Sumitomo Pharmaceuticals Company, Limited
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Patent number: 5066666Abstract: compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >.dbd.N.dbd.OR.sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, wherein R.sup.5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR3## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.Type: GrantFiled: January 26, 1990Date of Patent: November 19, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Yukinori Ozato, Nobuhiko Tamura, Hiroaki Masumori, Michihiro Yamamoto, Atsuyuki Kojima, Fumio Nishikaku, Yoshihiko Kimura
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Patent number: 5059590Abstract: Disclosed are imidazole derivatives represented by formula [I]: ##STR1## wherein R is a hydrogen atom or ##STR2## wherein R.sup.2 is a hydrogen atom or a hydroxy protecting group, R.sup.2 protecting either a single hydroxy or two hydroxies together when R.sup.2 is a hydroxy protecting group, and R.sup.3 is a hydrogen atom or OR.sup.2 ; A is CONH.sub.2 or CN; and R.sup.1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl.Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position.Furthermore, the compounds having remarkable antitumor activities and therefore can provide novel antitumor agents.Type: GrantFiled: February 28, 1989Date of Patent: October 22, 1991Assignees: Yamasa Shoyu Kabushiki Kaisha, Sumitomo Pharmaceuticals Company LimitedInventors: Tohru Ueda, Akira Matsuda, Noriaki Minakawa, Takuma Sasaki, Yoshikazu Yanagi
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Patent number: 5051444Abstract: The present invention relates to pyrrolidine derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2 are defined as herein. The compounds are useful as anti-amnestic agent.Type: GrantFiled: September 18, 1989Date of Patent: September 24, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Katsumi Tamoto, Renzo Ohuchi, Keiichi Ono
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Patent number: 5030626Abstract: There are disclosed herein novel derivatives of 26,26,26,27,27,27-hexafluorovitamin D.sub.3 providing excellent pharmacological effects, and a process for the preparation thereof. These novel compounds are represented by the general formula ##STR1## wherein R.sub.1 and R.sub.2 each denotes a hydrogen atom or a protecting group for the hydroxyl group; R.sub.3 and R.sub.4 each denotes a hydrogen atom, a hydroxyl group or a protected hydroxyl group and R.sub.4 ' and R.sub.5 ' each denotes a hydrogen atom, or alternatively R.sub.3 and R.sub.3 ' together or R.sub.4 and R.sub.4 ' together denote an oxo group; provided that R.sub.3, R.sub.3 ', R.sub.4 and R.sub.4 ' cannot denote hydrogen atoms simultaneously. The process for the preparation comprises subjecting a previtamin D.sub.3 derivative represented by the formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.3 ', R.sub.4 and R.sub.4 ' are as defined above, to thermal isomerization to give a vitamin D.sub.Type: GrantFiled: April 24, 1990Date of Patent: July 9, 1991Assignees: Sumitomo Pharmaceuticals Company, Limited, Taisho Pharmaceutical Co., Ltd.Inventors: Noritaka Hamma, Yoshikazu Saito, Toshio Nishizawa, Takashi Katsumata, Itsuro Sugata
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Patent number: 5021435Abstract: A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, an aryl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, R.sub.3 is a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, a C.sub.3 -C.sub.Type: GrantFiled: January 17, 1989Date of Patent: June 4, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Naruhito Masai, Masao Enomoto, Atsuyuki Kojima, Hiroaki Masumori, Nobuyuki Hara, Youichi Hara, Shigeaki Morooka
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Patent number: 5021241Abstract: A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, preferably collagen, gelatin, and a mixture thereof). The sustained release preparation can be administered to the body or implanted into the body by injection or an injection-like method and can release the active ingredient at an effective level for a long period of time when administered.Type: GrantFiled: April 28, 1988Date of Patent: June 4, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Yoshiya Yamahira, Keiji Fujioka, Shigeji Sato, Yoshihiro Takada
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Patent number: 5011692Abstract: The invention relates to sustained pulsewise release pharmaceutical preparation which comprices drug-containing polymeric material layers (layers A) and polymeric material layers containing the drug in question only in a slight amount or free of the drug (layers B) disposed alternatingly, with the whole surface extending in the direction perpendicular to the layer plane being coated with a polymeric material which is insoluble in water or scarcely soluble in water (polymeric material C).This pharmaceutical preparation of this invention is designed so that active ingredients which should desirably be released pulsewise can be released therefrom in a pulse-like and clinically significant manner and thereby the pharmacological effects of said active ingredients can be maintained for a prolonged period of time.Type: GrantFiled: December 23, 1986Date of Patent: April 30, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Keiji Fujioka, Shigeji Sato, Yoshihiro Takada, Yoshio Sasaki, Nobuhiko Tamura
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Patent number: 4992455Abstract: Thiazolidin-4-one derivative represented by the folowing general formula (I) and acid addition salts thereof ##STR1## wherein; R.sup.1 and R.sup.2 are the same or different and denote each(i) a residue represented by the general formula--A--R.sup.4wherein, A denotes a single bond, C.sub.1 -C.sub.8 alkylene, C.sub.2 -C.sub.8 alkenylene, or C.sub.2 -C.sub.8 alkynylene and R.sup.4 denotes hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.1 -C.sub.6 haloalkyl, or(ii) a residue represented by the general formula{(CH.sub.2).sub.n O}.sub.m {(CH.sub.2).sub.n' O}B--R.sup.5wherein, B denotes a single bond or C.sub.1 -C.sub.6 alkylene, R.sup.5 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, substituted silyl, or substituted or unsubstituted aryl, n and n' denote each an integer of 2 to 4, m denotes an integer of 1 to 3, and m' denotes an integer of 0 to 2; andR.sup.3 denotes hydrogen, C.sub.1 -C.sub.Type: GrantFiled: May 19, 1988Date of Patent: February 12, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Masao Enomoto, Atsuyuki Kojima, Yoshihiro Komuro, Shigeaki Morooka, Shunji Aono, Yuzuru Sanemitsu, Masato Mizutani, You Tanabe
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Patent number: 4990530Abstract: Injections containing anhydrous sodium indomethacin and methods for producing injections containing an hydrous sodium indomethacin which comprise converting a solution of indomethacin to a solution of sodium indomethacin by adding dropwise an aqueous solution of a carbonate of sodium, followed by freeze-drying and heating.The injections of the present invention are practically useful indomethacin injections in which sodium indomethacin anhydride has high safety and chemically high purity and stability, and the lyophilized pharmaceutical preparations are excellent also in that redissolution thereof is facilitated. By the methods for the production of the present invention, it is possible to produce said anhydrous sodium indomethacin efficiently.Type: GrantFiled: August 2, 1989Date of Patent: February 5, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Hiroshi Takenaka, Masatoshi Hasegawa, Shu Matsuda
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Patent number: 4985253Abstract: A sustained release composition applicable for human beings and mammals which comprises (a) a silicone elastomer and (b) a pharmaceutical substance optionally with (c) albumin. When the pharmaceutical substance is of high molecular weight, and can exert its pharmaceutical effect in a trace amount, its continuous release over a long period is attained by application of this invention.Type: GrantFiled: February 16, 1990Date of Patent: January 15, 1991Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Keiji Fujioka, Shigeji Sato, Nobuhiko Tamura, Yoshihiro Takada
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Patent number: 4963529Abstract: Growth hormone releasing factor (GRF) preparation which is excellent in stablity by having human serum albumin or glycine incorporated therein, with or without buffer. An amount of human serum albumin or glycine contained is usually 100 .mu.g to 30 mg per 100 .mu.g GRF. The preparation may be in the solid or solution form, preferably in the lyophilized form. An amount of buffer, if added, is preferably enough so that pH of the preparation is kept at 2-7. More preference is that the preparation is kept in nitrogen gas atmosphere. The lyophilized preparation is readily usable for, for example, injection.Type: GrantFiled: March 8, 1988Date of Patent: October 16, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Keiji Fujioka, Shigeji Sato, Yoshihiro Takada
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Patent number: 4962103Abstract: A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is a hydrogen atom or a conventional protecting group for a carboxyl group, R.sub.0 is a hydrogen atom or a conventional protecting group for a hydroxyl group, X is a protected or unprotected amino group, a carboxyl group, a lower alkoxycarbonyl group, an ar(lower)alkyloxycarbonyl group, a cyano group, a hydroxyl group, a lower alkyloxy group, a lower alkylthio group, a lower alkylsulfonyl group or a group of either one of the following formulas: ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or they are taken together to represent an alkylene chain to form, in combination with the adjacent nitrogen atom, a 3- to 7-membered cyclic amino group,--ZCOR.sub.5 (2)wherein Z represents --NH-- or --O-- and R.sub.Type: GrantFiled: March 17, 1989Date of Patent: October 9, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Makoto Sunagawa, Haruki Matsumura, Takaaki Inoue, Masamoto Fukasawa, Masuhiro Kato
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Patent number: 4950234Abstract: A device for administering solid or semisolid preparations in an organism subcutaneously. The equipment comprises a barrel having a nozzle for attachment of a hollow needle, a plunger slidably arranged in the barrel and is used in combination with a guide member adapted to be snugly accommodated within the lumen of the barrel. The solid preparations are generally housed in the guide member and/or needle and forced into the body subcutaneously through the needle.Type: GrantFiled: May 25, 1988Date of Patent: August 21, 1990Assignees: Sumitomo Pharmaceuticals Company, Limited, Nissho CorporationInventors: Keiji Fujioka, Nobuhiko Tamura, Yoshihiro Takada, Kenji Himeshima
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Patent number: 4948799Abstract: An imide derivative of the formula: ##STR1## or a pharmaceutically acceptable salt, which is useful as an antipsychotic drug.Type: GrantFiled: January 4, 1989Date of Patent: August 14, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Atsuyuki Kojima, Kukuo Ishizumi
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Patent number: 4937249Abstract: A compound of the formula: ##STR1## or its acid addition salt, which is useful as a psychotic drug.Type: GrantFiled: October 25, 1988Date of Patent: June 26, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Kikuo Ishizumi
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Patent number: 4914112Abstract: A compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >C.dbd.N--OR.sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, ##STR3## wherein R.sup.5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR4## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.Type: GrantFiled: May 28, 1987Date of Patent: April 3, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Yukinori Ozato, Nobuhiko Tamura, Hiroaki Masumori, Michihiro Yamamoto, Atsuyuki Kojima, Fumio Nishikaku, Yoshihiko Kimura
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Patent number: 4900304Abstract: A device for administering solid or semisolid preparations under the skin, which comprises a solid needle member with an acute tip end, and a cylindrical member slidably mounted on the needle member. The solid needle member having a recess at its front part to form a preparation chamber between the needle member and cylindrical member, and the chamber being opened or closed by moving the cylindrical member in the direction parallel to the axis of the needle member. The device may comprises a cylindrical member with a capsule chamber, a hollow needle member removable mounted on the front end of the cylindrical member, and a plunger slidably arranged in the capsule chamber of the cylindrical member, all of which have a common axis so that the plunger enters into the hollow needle member through the capsule chamber.Type: GrantFiled: July 30, 1987Date of Patent: February 13, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Keiji Fujioka, Shigeji Sato, Nobuhiko Tamura, Yoshihiro Takada, Yoshio Sasaki
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Patent number: 4892961Abstract: An amino acid derivative of the formula: ##STR1## wherein R.sup.1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.Type: GrantFiled: July 28, 1986Date of Patent: January 9, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Shiro Terashima, Yoshikazu Kimura, Yoshio Ito, Kunikazu Sakai, Tamejiro Hiyama
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Patent number: 4888344Abstract: (4R,5S,6S 8R,2'S,4'S)-3-[4-(2-Dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1- hydroxyethyl)-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid of the formula: ##STR1## in a crystalline form, which is useful as an antibiotic agent.Type: GrantFiled: July 30, 1987Date of Patent: December 19, 1989Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Makoto Sunagawa, Yutaka Isobe, Yutaka Takeuchi, Haruki Matsumura, Yukio Ozaki, Tetsuo Noguchi
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Patent number: 4855134Abstract: A sustained-release preparation of indomethacin or interferon comprising the active ingredient in admixture with a pharmaceutically acceptable biodegradable carrier, particularly a carrier selected from collagen, gelatin, and a mixture thereof. The preparation is particularly suitable for parenteral administration and can release the active ingredient in an effective amount for a long period of time.Type: GrantFiled: April 24, 1986Date of Patent: August 8, 1989Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Yoshiya Yamahira, Keiji Fujioka, Shigeji Sato