Patents Assigned to SUMMA HEALTH SYSTEMS
  • Patent number: 11583571
    Abstract: Stromal Derived Factor-1 (SDF-1) is a small, naturally occurring, potent chemokine with inherent angiogenic, neurogenic, anti-apoptotic protein, which is also a potent stem cell chemoattractant, cardiovascular disease, and other metabolic disturbances. The present invention provides methods for treating erectile dysfunction in a male subject comprising administering to the major pelvic ganglion supplying the cavernous nerves subject compositions comprising SDF-1. SDF-1 promotes stem cell activation, to the major pelvic ganglion supplying the cavernous nerves, helps cell preservation, and prevents adverse penile remodeling. It can be administered as a protein or by gene therapy including but not limited to plasmid DNA, viral transduction, or nanoparticle delivery directly to the penis or to the neurovascular bundle or other pelvic nerve structures during the time of surgery, or before injury, or to treat existing erectile dysfunction.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: February 21, 2023
    Assignees: The Johns Hopkins University, Summa Health System
    Inventors: Nikolai Sopko, Trinity Bivalacqua, Marc Penn
  • Patent number: 9050265
    Abstract: Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective amount of vitamin C, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in combination with vitamin K, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: June 9, 2015
    Assignee: Summa Health System
    Inventors: James M. Jamison, Thomas M. Miller, Deborah R. Neal, Mark Willam Kovacik, Michael John Askew, Richard Albert Mostardi
  • Publication number: 20140200270
    Abstract: Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a polycystic disease in a subject, comprising administering to the subject a therapeutically effective amount of vitamins C and K.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 17, 2014
    Applicants: SUMMA HEALTH SYSTEM, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Tetyana V. Masyuk, Nicholas F. Larusso, James M. Jamison, Thomas M. Miller
  • Patent number: 8751254
    Abstract: A method for tracking an associated patient's progression through rehabilitation includes providing a database, providing a graphic user interface, establishing a functional work capacity for the associated patient, determining a workload based on the functional work capacity, acquiring data from the associated patients' rehabilitation exercises, entering the data into the database, creating a graphical representation of the data, and comparing the data with the workload.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: June 10, 2014
    Assignee: Summa Health Systems
    Inventors: James Rosneck, Donald Noe
  • Patent number: 8680142
    Abstract: The combination of compounds of the hydroxytolan family with ascorbate plus naphthoquinone (Vitamin K3; VK3), or a quinone or semiquinone analogue of VK3, kill tumor cells, inhibit tumor growth and development, and treat cancer in subjects in need thereof.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: March 25, 2014
    Assignees: Kent State University, Summa Health System
    Inventors: Chun-che Tsai, James M. Jamison, Jackie L. Summers
  • Patent number: 8507555
    Abstract: Compositions comprising combinations of magnesium ascorbate (magnesium Vitamin C of “MgVC2”) and Vitamin K3 or (VK3) or a quinone and semiquinone analogue of VK3, are used in methods for killing or inhibiting the growth of tumor or cancer cells or preneoplastic cells in a subject, or for treating cancer in a subject in need of such treatment.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: August 13, 2013
    Assignee: Summa Health System
    Inventors: Thomas M. Miller, James M. Jamison
  • Publication number: 20120184609
    Abstract: Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective amount of vitamin C, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in combination with vitamin K, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
    Type: Application
    Filed: July 19, 2010
    Publication date: July 19, 2012
    Applicant: SUMMA HEALTH SYSTEM
    Inventors: James M. Jamison, Thomas M. Miller, Deborah R. Neal, Mark Willam Kovacik, Michael John Askew, Richard Albert Mostardi
  • Publication number: 20120123803
    Abstract: A method and system of transforming patient care including a multi-disciplinary strategy consisting of the adoption of a “code” alert used to mobilize and coordinate all treatment caregivers, improve regional paramedic education, and a database to track the progress of a patient as they move through the emergency medical system is described. In an effort to reduce the elapsed time from when the patient first encounters medical providers to the time of treatment, the time intervals during a patient's treatment travel are tracked and analyzed to highlight areas that need to be improved upon.
    Type: Application
    Filed: November 17, 2011
    Publication date: May 17, 2012
    Applicant: Summa Health System
    Inventors: Mark W. Kovacik, Donald A. Noe
  • Publication number: 20100267731
    Abstract: A pharmaceutical composition useful in the prevention of subconjunctival scarring that may occur after GFS comprising an effective amount of an ALK-5 inhibitor. Also disclosed is a method of treating disorder or condition of other ocular scarring or fibrosis including corneal haze and PVR that may develop after ocular surgery or injury comprising applying an amount of a pharmaceutical composition including an ALK-5 inhibitor to a post-surgical or injury site.
    Type: Application
    Filed: April 16, 2010
    Publication date: October 21, 2010
    Applicant: Summa Health Systems, LLC
    Inventor: Hiroshi Nakamura
  • Publication number: 20100056625
    Abstract: Compositions comprising combinations of magnesium ascorbate (magnesium Vitamin C of “MgVC2”) and Vitamin K3 or (VK3) or a quinone and semiquinone analogue of VK3, are used in methods for killing or inhibiting the growth of tumor or cancer cells or preneoplastic cells in a subject, or for treating cancer in a subject in need of such treatment.
    Type: Application
    Filed: June 15, 2007
    Publication date: March 4, 2010
    Applicant: SUMMA HEALTH SYSTEM
    Inventors: Thomas M. Miller, James M. Jamison
  • Publication number: 20090063194
    Abstract: A method for tracking an associated patient's progression through rehabilitation includes providing a database, providing a graphic user interface, establishing a functional work capacity for the associated patient, determining a workload based on the functional work capacity, acquiring data from the associated patients' rehabilitation exercises, entering the data into the database, creating a graphical representation of the data, and comparing the data with the workload.
    Type: Application
    Filed: August 11, 2008
    Publication date: March 5, 2009
    Applicant: SUMMA HEALTH SYSTEMS
    Inventors: JAMES ROSNECK, DONALD NOE
  • Publication number: 20070043110
    Abstract: A combination of Vitamin C and a quinone used as a supplemental treatment for an ovarian cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, intravenously, or intraperitoneally. Oral administration may be in the form of capsules containing a predetermined ratio of Vitamin C to Vitamin K3. The supplemental treatment is effective to inhibit metastases of cancer cells and inhibit tumor growth. The ratio of Vitamin C to Vitamin K3 is in the range of about 50 to 1 to about 250 to 1. A method for evaluating the effectiveness of the supplemental treatment includes monitoring the patient's serum DNase activity throughout the course of treatment.
    Type: Application
    Filed: August 14, 2006
    Publication date: February 22, 2007
    Applicant: Summa Health System
    Inventors: Jacques Gilloteaux, Henryk Taper, James Jamison, Jack Summers
  • Patent number: 7091241
    Abstract: A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, intravenously, or intraperitoneally. Oral administration may be in the form of capsules containing a predetermined ratio of Vitamin C to Vitamin K3. The supplemental treatment is effective to inhibit metastases of cancer cells and inhibit tumor growth. The ratio of Vitamin C to Vitamin K3 is in the range of about 50 to 1 to about 250 to 1. A method for evaluating the effectiveness of the supplemental treatment includes monitoring the patient's serum DNase activity throughout the course of treatment.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: August 15, 2006
    Assignee: Summa Health System
    Inventors: Jacques Gilloteaux, Henryk S. Taper, James M Jamison, Jack L. Summers
  • Patent number: 5460970
    Abstract: A chromatographic method used to detect chronic alcohol usage and alcoholism and to monitor alcohol rehabilitation treatment; the method provides improved resolution of the Hb A.sub.1-AcH peak from the contiguous Hb A.sub.1c peak by means of a polyaspartic acid chromatographic column and a nonlinear buffer gradient; the resulting Hb A.sub.1-AcH peak is then evaluated to determine chronic alcohol usage which is indicative of alcoholism and which can be used to monitor alcohol rehabilitation treatment.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: October 24, 1995
    Assignee: Summa Health System
    Inventors: Edward B. Truitt, Jr., Susan E. Hazelett, Robert A. Liebelt