Abstract: The present disclosure provides for improved methods for treating pain, including pain associated with chronic inflammatory diseases, neuropathic pain and cancer by using ?-adrenergic antagonists and ?-adrenergic agonists (particularly ?2-adrenergic agonists) alone or in combination.
Abstract: The present invention discloses a novel compound and method for the treatment of inflammatory autoimmune diseases, for example, rheumatoid arthritis, using ?-adrenergic antagonists and ?-adrenergic agonists in combination. Treatment of animals, namely humans, with an ?-adrenergic antagonist, preferably, phentolamine, and a ?-adrenergic agonist, preferably terbutaline, in combination can significantly suppress the joint destruction and inflammation due to disease in these animals.