Abstract: The present invention relates to a method for enabling hospitals or clinics to administer a dose of a drug to patients in need thereof while avoiding steps of manipulation, dilution, reconstitution, dispensing, sterilization, transfer, handling or compounding before intravenous administration. The present invention further relates to a perfusion system comprising different sets of perfusion containers, each container comprising a ready-to-infuse, stable, sterile, aqueous perfusion solution of a drug, wherein the set of perfusion containers alone or in combination provides for direct intravenous administration of a desired dose of the drug to a patient in need thereof, such that the delivered dose is equal to or within ±5% of the calculated dose.
Abstract: The present invention provides processes for the preparation of ibrutinib, intermediate compounds of Formula VI and Formula VIII, and salts thereof. The processes of the present invention are commercially viable, cost-effective, environmentally friendly, and make use of inexpensive, non-hazardous, safe chemicals that are easy to handle.
Abstract: The present invention relates to pharmaceutical compositions comprising dimethyl fumarate and a pharmaceutically acceptable agent which inhibits the enzyme catalyzed degradation of dimethyl fumarate.
Abstract: The present invention relates to novel gastroretentive dosage systems, in particular, a floating capsule which releases the drug without any lag time and which remains buoyant for a sufficient period of time in the stomach. Further, the invention relates to the process of preparation thereof.
Type:
Grant
Filed:
October 11, 2012
Date of Patent:
November 27, 2018
Assignee:
Sun Pharmaceutical Industries Limited
Inventors:
Varinder Kumar, Shavej Ahmad, Romi Barat Singh
Abstract: The present invention provides novel salts of nilotinib and polymorphs thereof. The acid addition salts of nilotinib with benzenesulfonic acid, butanedisulfonic acid, 1-5-naphthalenedisulfonic acid, naphthalene-1-sulfonic acid and 1-hydroxynaph-thoic acid; hydrates and anhydrates thereof.
Abstract: The present invention relates to a topical pharmaceutical composition comprising acitretin and a process for its preparation. It also relates to a method of treating skin disorders by administering said topical pharmaceutical composition.
Abstract: The present invention relates to a topical solution comprising a retinoid or its pharmaceutically acceptable salts thereof and a process of preparing it.
Type:
Grant
Filed:
May 20, 2010
Date of Patent:
November 13, 2018
Assignee:
Sun Pharmaceutical Industries Limited
Inventors:
Sanjay Kumar Motwani, Shashikanth P. Isloor, Vinod Arora
Abstract: The present invention relates to a method for enabling hospitals or clinics to administer a dose of a drug to patients in need thereof while avoiding steps of manipulation, dilution, reconstitution, dispensing, sterilization, transfer, handling or compounding before intravenous administration. The present invention further relates to a perfusion system comprising different sets of perfusion containers, each container comprising a ready-to-infuse, stable, sterile, aqueous perfusion solution of a drug, wherein the set of perfusion containers alone or in combination provides for direct intravenous administration of a desired dose of the drug to a patient in need thereof, such that the delivered dose is equal to or within ±5% of the calculated dose.
Abstract: The present invention relates to pharmaceutical compositions comprising dimethyl fumarate and a pharmaceutically acceptable agent which inhibits the enzyme catalyzed degradation of dimethyl fumarate.
Abstract: The present invention provides crystalline Form S of regadenoson which is substantially free of residual organic solvent and having an X-ray powder diffraction pattern comprising characteristic peak at 10.3, 10.8, 19.0, 21.6 and 25.5±0.2 degrees 2?.
Abstract: The present invention relates to a topical solution comprising a retinoid or its pharmaceutically acceptable salts thereof and process of preparing it.
Abstract: The present invention provides a crystalline Form I of afatinib dimaleate, its process for preparation and pharmaceutical composition thereof, and its use in the treatment of metastatic non-small cell lung cancer.
Abstract: An oral pharmaceutical composition of isotretinoin and a carrier substrate, having isotretinoin in the form of gel, dispersion, solution or emulsion, which is absorbed onto the carrier substrate to form solid particles, powder, or granules. The oral pharmaceutical composition has enhanced bioavailability. A process is used for preparing the oral composition.
Abstract: The present invention relates to a ready-to-administer parenteral dosage form of norepinephrine which comprises an aqueous solution of norepinephrine, having an anti-oxidant which is not a sulfite anti-oxidant, wherein the dosage form is stable at room temperature for prolonged period of time.
Type:
Application
Filed:
January 19, 2018
Publication date:
May 24, 2018
Applicant:
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Inventors:
Rakesh THUMMAR, Shantaram PAWAR, Prashant KANE, Subhas Balaram BHOWMICK, Samarth KUMAR, Milan Natvarbhai THAKKAR, Kandarp Maheshkumar DAVE
Abstract: The present invention relates to oral liquid compositions of guanfacine. The liquid compositions can be immediate release or extended release compositions. The compositions comprise guanfacine in a concentration from about 0.1 mg/mL to about 12.0 mg/mL of the composition. The liquid compositions can be in the form of ready-to use liquid compositions or reconstituted liquid compositions. It further relates to processes for the preparation of said oral liquid compositions.
Abstract: The present invention relates to a method for preparing a stable extended release suspension composition comprising multiple coated cores of an active ingredient by using a suspension base, wherein the suspension base ensures substantially similar in-vitro dissolution release profile of the active ingredient upon storage of the suspension compositions for at least seven days.
Type:
Grant
Filed:
May 6, 2016
Date of Patent:
May 8, 2018
Assignee:
Sun Pharmaceutical Industries Limited
Inventors:
Romi Barat Singh, Ashish Kumar, Rajesh Srikrishan Shear, Satish Kumar Jain, Paras P. Jain
Abstract: The present invention provides a crystalline form of baricitinib characterized by an XRPD pattern substantially as depicted in FIG. 1, a process for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
Abstract: The present invention relates to a modified-release, once-daily, oral pharmaceutical composition comprising isotretinoin and a process for its preparation. In some embodiments, the disclosure is directed to a modified-release, oral pharmaceutical composition comprising isotretinoin or a pharmaceutically acceptable salt, ester or a derivative thereof; and a release modifying agent, wherein the composition is suitable for once daily administration. In some embodiments, the disclosure is directed to a modified-release, oral pharmaceutical composition comprising isotretinoin, wherein the composition comprises an immediate-release component; and a modified-release component comprising a release modifying agent, and wherein the composition is suitable for once daily administration.
Type:
Application
Filed:
November 24, 2017
Publication date:
March 15, 2018
Applicant:
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Inventors:
Sumit MADAN, Anuj Kumar FANDA, Pankaj Prabhakar AMRUTKAR, Rajesh RAO, Jitendra KAWADKAR, Vasu Kumar KAKUMANU, Ravi KOCHHAR, Romi Barat SINGH, Dileep JAMI, Lokesh GARG, Sandipan ROY
Abstract: The present invention relates to a ready-to-administer parenteral dosage form of norepinephrine which comprises an aqueous solution of norepinephrine, having an anti-oxidant which is not a sulfite anti-oxidant, wherein the dosage form is stable at room temperature for prolonged period of time.
Type:
Grant
Filed:
August 27, 2015
Date of Patent:
January 30, 2018
Assignee:
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Inventors:
Thummar Rakesh, Pawar Shantaram, Kane Prashant, Bhowmick Subhas Balaram, Kumar Samarth, Thakkar Milan Natvarbhai, Dave Kandarp Maheshkumar