Abstract: Inhibitors of integrin-linked kinase (ILK) are used in the treatment of inflammatory disease, including cutaneous inflammatory diseases, such as psoriasis, scleroderma, systemic lupus erythematosus and atopic dermatitis.

Abstract: A method for producing an ECG-triggered retrospective color-flow ultrasound image comprises generating ultrasound, transmitting the ultrasound into a subject at a first location, wherein a first reference point of an ECG signal taken from the subject triggers the ultrasound transmission, receiving ultrasound reflected from the subject at the first location, transmitting the ultrasound into the subject at a second location, wherein a second reference point of an ECG signal taken from the subject triggers the ultrasound transmission receiving ultrasound reflected from the subject at the second location, processing the received ultrasound to form ultrasound color traces, and reconstructing the ultrasound color traces to form the ultrasound image.

Abstract: ILK genetic sequences and methods of use are provided. In some embodiments, a fragment or portion of an ILK polynucleotide is provided, where the polynucleotide has a sequence consisting of contiguous nucleotides within the provided ILK sequences, which may be within the provided ILK coding sequences. Such polynucleotides may be DNA, RNA, and the like, and may be double stranded or single stranded.

Abstract: A method and apparatus for determining a degree of deflection in a breast compression plate. The mammography apparatus further includes an optical measuring device. The method and apparatus involve (a) providing a pattern on the breast compression plate, the pattern being imagable by the optical measuring device, and having a plurality of local pattern indicia; (b) adjusting the breast compression plate to a selected height; (c) imaging the breast compression plate using the optical measuring device to provide an image of the pattern, the image having a plurality of local image indicia including an associated local image indicia for each local pattern indicia in the plurality of local pattern indicia; and (d) for each local pattern indicia in the plurality of local pattern indicia, determining an associated local deflection of the breast compression plate from the associated local image indicia.

Abstract: The invention relates to canine embryonic stem cells, methods of cultivation and propagation of the cells, and production of differentiated cells. The embryonic stem cells may be obtained by isolating a canine embryo, culturing the embryo in the presence of a feeder layer and one or more proliferation agent, removing a blastocyst outgrowth, and culturing the outgrowth in the presence of a fresh feeder layer.

Abstract: A method, computer software product and computer system for analyzing digital mammograms. The method, computer software product and computer system involve a generating phantom thickness object; receiving a set of dimensions for a breast; and, transforming the phantom thickness object to conform to the set of dimensions for the breast to provide the three-dimensional breast thickness object.

Abstract: The present invention provides a practical design of a megavoltage x-ray detector with both high quantum efficiency (QE) and high resolution. The x-ray detector disclosed herein has a QE that can be an order of magnitude higher than that of current flat panel systems and yet has a spatial resolution equivalent to that of current flat panel systems used for portal imaging. The x-ray detector includes a large number of micro-structured electrically conducting plates, packed together with thin spacers placed between neighboring plates with the micro-structured plates oriented to be parallel to the incident x-rays in operation. Each plate includes an electrically conductive substrate with a first planar surface, elongate electrically conductive strip electrodes separated from each other with strip spacers placed in between and sitting on an insulating layer interposed between the first planar surface of the electrically conductive substrate and the strip electrodes.

Abstract: A method and apparatus for determining a degree of deflection in a breast compression plate. The mammography apparatus further includes an optical measuring device. The method and apparatus involve (a) providing a pattern on the breast compression plate, the pattern being imagable by the optical measuring device, and having a plurality of local pattern indicia; (b) adjusting the breast compression plate to a selected height; (c) imaging the breast compression plate using the optical measuring device to provide an image of the pattern, the image having a plurality of local image indicia including an associated local image indicia for each local pattern indicia in the plurality of local pattern indicia; and (d) for each local pattern indicia in the plurality of local pattern indicia, determining an associated local deflection of the breast compression plate from the associated local image indicia.

Abstract: A method is described for making a composite, such as a piezoelectric composite, having a predetermined volume ratio. Initially, a pair of base slabs are diced to form slot having uniform pitch spacing such that a material portion of one diced base slab may be received within the slots of another diced base slab. The diced base slabs are interdigitated and joined to form a first piezoelectric composite that can subsequently be diced to form slots having a uniform pitch spacing that are spaced from the first slots. Two diced first piezoelectric composites are interdigitated and joined to form a second piezoelectric composite of reduced volume ratio and finer pitch.

Abstract: The present invention discloses a method for determining the position and/or orientation of a catheter or other interventional access device or surgical probe using phase patterns in a magnetic resonance (MR) signal. In the method of the invention, global two-dimensional correlations are used to identify the phase pattern and orientation of individual microcoils, which is unique for each microcoil's position and orientation. In a preferred embodiment of the invention, tracking of interventional devices is performed by one integrated phase image projected onto the axial plane and a second image in an oblique plane through the center of the coil and normal to the coil plane. In another preferred embodiment, the position and orientation of a catheter tip can be reliably tracked using low resolution MR scans clinically useful for real-time interventional MRI applications.

Abstract: Disclosed herein is a patient transfer device comprising lifting arrangement positionable adjacent a patient and movable between a first position and a second position, and support arrangement for supporting the patient. The support arrangement is attachable to the lifting arrangement along a number of anchor locations thereon, the anchor locations including a pair of central anchor locations, a first pair of outer anchor locations on one side of the pair of central anchor locations and a second pair of outer anchor locations on an opposite side of the central pair of anchor locations; the support arrangement including a pair of central contact locations near a central location on the body of the patient, a first pair of outer contact locations on one side of the pair of central contact locations and a second pair of outer contact locations on an opposite side of the central pair of contact locations.

Abstract: Magnetic resonance imaging (MRI) uses direct, continuous, unaliased, real-time imaging for motion compensation. Unaliased, real-time two dimensional (2D) images are acquired continuously of the anatomy of interest. The images are compared to at least one template to using a correlation coefficient technique to select images corresponding to minimal motion and distortion. A spatial grid of templates can be used to cover an anatomy of interest. Multiple temporal templates can be used to create a time series of magnetic resonance (MR) images. The selected images are used to provide a high-resolution image, preferably a three dimensional (3D) image.

Abstract: The present invention relates to the field of cancer immunotherapy. In particular, vaccines are administered in conjunction with high doses of cytokines to enhance an anti-tumor immune response.

Abstract: Realtime magnetic resonance imaging (MRI) uses cardiac and respiratory monitoring tools to avoid or minimize motion-induced image artifacts. A series of initial MR images are associated with the physiological data from the cardiac, respiratory, or other monitoring tools. The tools provide physiological data in conjunction with anatomic or spatial information such that the optimal gating times (i.e., for acquiring MR image data) in the cardiac and respiratory cycles can be identified and the optimal acquisition durations are identified relative to the physiological data. The process then uses MRI with the identified optimal gating times and acquisition durations to produce a high quality output image of the anatomy of interest. The high quality image can be one or more of the following: a two-dimensional (2D) with a higher signal-to-noise ratio (i.e.

Abstract: Apparatus for nuclear magnetic resonance includes a sample container, a receiver coil adjacent to and surrounding the sample container and a flux return yoke for directing magnetic flux from the same falling outside the receiver coil back thereto, the yoke comprising a material having a variable magnetic permeability tuned for a particular frequency range. The material of the return yoke with a variable magnetic permeability includes an array of capacitive/inductive elements. Each capacitive/inductive element has a low resistance conducting path and is configured such that a magnetic component (H) of electromagnetic radiation lying within a predetermined frequency band induces an electrical current (j(x)) to flow around said path and through the associated element. The size of the elements and their spacing apart are selected to provide a predetermined permeability in response to the received electromagnetic radiation.

Abstract: The present invention is directed to an imaging-compatible device for insertion into a region of tissue under image guidance, which employs ultrasound energy for the generation of thermal lesions. Coagulation can be confined to particular sectors in tissue through rotational control of the device. The depth of coagulation can be controlled through simultaneous modulation of the operating frequencies and powers. Described is a device which comprises a transducer located within a housing suitable for tissue insertion. The transducer comprises at least one piezoceramic element with at least one acoustic matching layer comprising a high acoustic impedance material for generating acoustic energy in narrow passbands around multiple resonant frequencies with high acoustic efficiency. The magnitude and frequency of the electrical power delivered to each element can be manipulated simultaneously providing control over the 3-dimensional shape of the thermal lesion created in tissue.

Abstract: The invention relates to overcoming anti-cancer therapy resistance in melanoma by regulation of the expression of tyrosinase related protein 2 (TYRP2). Treatment of melanoma with anti-cancer therapy may be negatively impacted by anti-cancer resistance of melanoma cells. Altering expression of TYRP2 in melanoma cells can enhance efficacy of anti-cancer therapies, such as chemotherapy and radiotherapy. Methods for treatment of melanoma are disclosed, as well as methods for diagnosis of anti-cancer therapy resistance, and methods for evaluating candidate anti-cancer therapies for melanoma. Down-regulation of TYRP2 expression or activity can be accomplished using a genetic therapy such as antisense therapy, or by using small molecules which regulate TYRP2.

Abstract: A plurality of objects are concurrently studied in a common MRI apparatus wherein the RF excitation is distributed to one plurality of K RF coils of N said pluralities of RF coils and one of each of said N is switched to a corresponding one of K RF receivers. The interaction of the several coils is further minimized by selectably detuning each coil except for an active coil(s).

Abstract: A hand washing apparatus has a hand washing bowl (30) mounted when in use at a suitable height for washing the hands. The bowl (30) and its cover are reconfigurable between a hand washing position and an inactive position. The hand washing apparatus includes controls for reconfiguring the bowl and its cover between a hand washing position and an inactive position, a dispenser (34) for dispensing water over the hands in the bowl and a dispenser (34) for dispensing soap over the hands in the bowl. Also disclosed is a method of cleaning the hands using such apparatus.

Abstract: The present invention is directed to a method and system for tracking the motion of fluid traveling through a vessel and determining its velocity spectrum from magnetic resonance data collected within a single cycle. The present invention provides a process of independently acquiring and processing MR data from a single cardiac cycle. By combining a SPAMM excitation with a two-dimensional selective excitation, suitable tags of fluid flowing through the vessel may be created. The combination of the excitations produces a sinusoidal variation of transverse magnetization along a column of the fluid. A succession of gradient echoes are then collected to provide information about the flow of fluid in the excited vessel. Each gradient echo undergoes a transformation to obtain a 1-D projection of the excited fluid across the vessel. The magnitudes of the projections are then used to construct a velocity spectrum of the fluid.