Abstract: Inhibitors of integrin-linked kinase (ILK) are used in the treatment of inflammatory disease, including cutaneous inflammatory diseases, such as psoriasis, scleroderma, systemic lupus erythematosus and atopic dermatitis.

Abstract: A method for producing an ECG-triggered retrospective color-flow ultrasound image comprises generating ultrasound, transmitting the ultrasound into a subject at a first location, wherein a first reference point of an ECG signal taken from the subject triggers the ultrasound transmission, receiving ultrasound reflected from the subject at the first location, transmitting the ultrasound into the subject at a second location, wherein a second reference point of an ECG signal taken from the subject triggers the ultrasound transmission receiving ultrasound reflected from the subject at the second location, processing the received ultrasound to form ultrasound color traces, and reconstructing the ultrasound color traces to form the ultrasound image.

Abstract: ILK genetic sequences and methods of use are provided. In some embodiments, a fragment or portion of an ILK polynucleotide is provided, where the polynucleotide has a sequence consisting of contiguous nucleotides within the provided ILK sequences, which may be within the provided ILK coding sequences. Such polynucleotides may be DNA, RNA, and the like, and may be double stranded or single stranded.

Abstract: The invention relates to canine embryonic stem cells, methods of cultivation and propagation of the cells, and production of differentiated cells. The embryonic stem cells may be obtained by isolating a canine embryo, culturing the embryo in the presence of a feeder layer and one or more proliferation agent, removing a blastocyst outgrowth, and culturing the outgrowth in the presence of a fresh feeder layer.

Abstract: A method, computer software product and computer system for analyzing digital mammograms. The method, computer software product and computer system involve a generating phantom thickness object; receiving a set of dimensions for a breast; and, transforming the phantom thickness object to conform to the set of dimensions for the breast to provide the three-dimensional breast thickness object.

Abstract: A method is described for making a composite, such as a piezoelectric composite, having a predetermined volume ratio. Initially, a pair of base slabs are diced to form slot having uniform pitch spacing such that a material portion of one diced base slab may be received within the slots of another diced base slab. The diced base slabs are interdigitated and joined to form a first piezoelectric composite that can subsequently be diced to form slots having a uniform pitch spacing that are spaced from the first slots. Two diced first piezoelectric composites are interdigitated and joined to form a second piezoelectric composite of reduced volume ratio and finer pitch.

Abstract: The present invention discloses a method for determining the position and/or orientation of a catheter or other interventional access device or surgical probe using phase patterns in a magnetic resonance (MR) signal. In the method of the invention, global two-dimensional correlations are used to identify the phase pattern and orientation of individual microcoils, which is unique for each microcoil's position and orientation. In a preferred embodiment of the invention, tracking of interventional devices is performed by one integrated phase image projected onto the axial plane and a second image in an oblique plane through the center of the coil and normal to the coil plane. In another preferred embodiment, the position and orientation of a catheter tip can be reliably tracked using low resolution MR scans clinically useful for real-time interventional MRI applications.

Abstract: Disclosed herein is a patient transfer device comprising lifting arrangement positionable adjacent a patient and movable between a first position and a second position, and support arrangement for supporting the patient. The support arrangement is attachable to the lifting arrangement along a number of anchor locations thereon, the anchor locations including a pair of central anchor locations, a first pair of outer anchor locations on one side of the pair of central anchor locations and a second pair of outer anchor locations on an opposite side of the central pair of anchor locations; the support arrangement including a pair of central contact locations near a central location on the body of the patient, a first pair of outer contact locations on one side of the pair of central contact locations and a second pair of outer contact locations on an opposite side of the central pair of contact locations.

Abstract: Magnetic resonance imaging (MRI) uses direct, continuous, unaliased, real-time imaging for motion compensation. Unaliased, real-time two dimensional (2D) images are acquired continuously of the anatomy of interest. The images are compared to at least one template to using a correlation coefficient technique to select images corresponding to minimal motion and distortion. A spatial grid of templates can be used to cover an anatomy of interest. Multiple temporal templates can be used to create a time series of magnetic resonance (MR) images. The selected images are used to provide a high-resolution image, preferably a three dimensional (3D) image.

Abstract: Apparatus for nuclear magnetic resonance includes a sample container, a receiver coil adjacent to and surrounding the sample container and a flux return yoke for directing magnetic flux from the same falling outside the receiver coil back thereto, the yoke comprising a material having a variable magnetic permeability tuned for a particular frequency range. The material of the return yoke with a variable magnetic permeability includes an array of capacitive/inductive elements. Each capacitive/inductive element has a low resistance conducting path and is configured such that a magnetic component (H) of electromagnetic radiation lying within a predetermined frequency band induces an electrical current (j(x)) to flow around said path and through the associated element. The size of the elements and their spacing apart are selected to provide a predetermined permeability in response to the received electromagnetic radiation.

Abstract: The present invention is directed to an imaging-compatible device for insertion into a region of tissue under image guidance, which employs ultrasound energy for the generation of thermal lesions. Coagulation can be confined to particular sectors in tissue through rotational control of the device. The depth of coagulation can be controlled through simultaneous modulation of the operating frequencies and powers. Described is a device which comprises a transducer located within a housing suitable for tissue insertion. The transducer comprises at least one piezoceramic element with at least one acoustic matching layer comprising a high acoustic impedance material for generating acoustic energy in narrow passbands around multiple resonant frequencies with high acoustic efficiency. The magnitude and frequency of the electrical power delivered to each element can be manipulated simultaneously providing control over the 3-dimensional shape of the thermal lesion created in tissue.

Abstract: The invention relates to overcoming anti-cancer therapy resistance in melanoma by regulation of the expression of tyrosinase related protein 2 (TYRP2). Treatment of melanoma with anti-cancer therapy may be negatively impacted by anti-cancer resistance of melanoma cells. Altering expression of TYRP2 in melanoma cells can enhance efficacy of anti-cancer therapies, such as chemotherapy and radiotherapy. Methods for treatment of melanoma are disclosed, as well as methods for diagnosis of anti-cancer therapy resistance, and methods for evaluating candidate anti-cancer therapies for melanoma. Down-regulation of TYRP2 expression or activity can be accomplished using a genetic therapy such as antisense therapy, or by using small molecules which regulate TYRP2.

Abstract: A plurality of objects are concurrently studied in a common MRI apparatus wherein the RF excitation is distributed to one plurality of K RF coils of N said pluralities of RF coils and one of each of said N is switched to a corresponding one of K RF receivers. The interaction of the several coils is further minimized by selectably detuning each coil except for an active coil(s).

Abstract: A hand washing apparatus has a hand washing bowl (30) mounted when in use at a suitable height for washing the hands. The bowl (30) and its cover are reconfigurable between a hand washing position and an inactive position. The hand washing apparatus includes controls for reconfiguring the bowl and its cover between a hand washing position and an inactive position, a dispenser (34) for dispensing water over the hands in the bowl and a dispenser (34) for dispensing soap over the hands in the bowl. Also disclosed is a method of cleaning the hands using such apparatus.

Abstract: An article of footwear and insert for an article of footwear are provided with means for stimulating cutaneous pressure sensation from the perimeter of the plantar surface (sole) of the foot. Increasing cutaneous sensation from the perimeter of the plantar foot surface provides the central nervous system of the wearer of the footwear with an increased ability to detect and react to shifts of the body's center of gravity toward the edges of the feet which, if left uncorrected, could result in a loss of balance or a fall. An insole is disclosed which is provided with an elongate member or a series of protrusions which form a narrow ridge in close proximity to the perimeter of the insole, the ridge being adapted to protrude upwardly against the plantar foot surface along at least a portion of the perimeter thereof.

Abstract: A clutch for altering the direction of a drive unit of a transportation device between a first direction of travel and a second direction of travel, the drive unit having at least one drive wheel connected to a shaft, the shaft being rotatably mounted with respect to the transportation device between at least a first position, corresponding to the first direction of travel, and a second position, corresponding to the second direction of travel, the clutch comprises a housing to receive a portion of the shaft, a lock having a first preset locked position corresponding to the first direction of travel and a second preset locked position corresponding to the second direction of travel and, a connecting member connected to the shaft and the lock for alternately locking the shaft in one of the directions of travel.

Abstract: A base for receiving a seat has a longitudinally extending chassis having a front end, a rear end, a central portion positioned therebetween and opposed sides extending longitudinally between the front and rear ends; at least one drive wheel mounted below the central portion; a plurality of rotatably mounted wheels positioned around the chassis and mounted at a fixed distance below the chassis; and a biasing member associated with the at least one drive wheel to bias the at least one drive wheel to engage the surface on which the base is situated and reduce the weight supported by the rotatably mounted wheels whereby the rotatably mounted wheels support sufficient weight of the base and the unoccupied seat to define a stable platform.

Abstract: A method for a person to wash their hands using a hand washing apparatus comprising a hand washing bowl having an interior and a cover which are reconfigurable between a hand washing position in which the person can wash their hands and an inactive position, a controller for reconfigurating the bowl between the hand washing position and the inactive position; and, a dispenser for dispensing water and a cleaner over the person's hands, the method comprising the steps of actuating the controller to rotate the bowl and the cover about an axis to the hand washing position; dispensing water and soap over the person's hands; and, dispensing water to rinse the person's hands.