Abstract: Certain tetrahydro-azepinoquinolines of structural formula I are agonists of the mammalian 5-HT2c receptor, and, in particular, are selective agonists of the mammalian 5-HT2c receptor. The compounds of the present invention are therefore useful for the treatment, control, or prevention of diseases, conditions, or disorders responsive to stimulation of the 5-HT2c receptor, such as obesity, obesity-related conditions, and certain CNS-related disorders, including schizophrenia and depression. They are also useful as aids for tobacco smoking cessation.
Type:
Grant
Filed:
August 26, 2015
Date of Patent:
November 20, 2018
Assignee:
Sunnylife Pharma, Inc.
Inventors:
Jonathan A. Groeper, Xibin Liao, Zhijian Lu
Abstract: Certain tetrahydro-azepinoquinolines of structural formula I are agonists of the mammalian 5-HT2c receptor, and, in particular, are selective agonists of the mammalian 5-HT2c receptor. The compounds of the present invention are therefore useful for the treatment, control, or prevention of diseases, conditions, or disorders responsive to stimulation of the 5-HT2c receptor, such as obesity, obesity-related conditions, and certain CNS-related disorders, including schizophrenia and depression. They are also useful as aids for tobacco smoking cessation.
Type:
Application
Filed:
August 26, 2015
Publication date:
August 2, 2018
Applicant:
Sunnylife Pharma, Inc.
Inventors:
Jonathan A. Groeper, Xibin Liao, Zhijian Lu