Abstract: A power saving wakeup device for wireless mouse is disclosed. The wireless mouse has a microprocessor with a wake-up pin, and is waked up from the power saving mode when the wake-up pin is triggered. The wakeup device includes a contact conductor and a flexible conductor. The contact conductor is connected to the wake-up pin of the microprocessor. The flexible conductor is connected to a predetermined voltage level and separated by a predetermined distance from the contact conductor, such that the flexible conductor can contact with the contact conductor when the flexible conductor is vibrated. Thus, when the wireless mouse is moved to cause the flexible conductor to contact with the contact conductor, the wake-up pin is triggered by the predetermined potential.