Abstract: An axle support system for supporting an axle for a wheelchair drive wheel includes an elongated wheelchair frame member. A portion of the surface of the elongated frame member is a frame contact surface, and a portion of the surface of the elongated frame member is an indexing section defined by a series of grooves separated by lands. A bracket is mounted for movement along the elongated wheelchair frame member. The bracket has an orifice for receiving a wheelchair drive wheel axle, a bracket contact surface, and a connector for securing the bracket to the elongated frame member. The frame contact surface of the elongated frame member is aligned with the bracket contact surface, thereby preventing rotation of the bracket with respect to the elongated frame member. The connector is engagable with a selected groove of the series of grooves of the elongated frame member to fix the position of the bracket along the elongated frame member.