Patents Assigned to Sunshine Lake Pharma Co., Ltd.
  • Thienopyrimidine derivative and use thereof in medicine
    Patent number: 10759812
    Abstract: The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: September 1, 2020
    Assignee: Sunshine Lake Pharma Co., Ltd.
    Inventors: Wanjun Tang, Xinye Yang, Zheng Gu, Chenlu Li, Zongyuan Zhang, Zhifu Wan, Xiaojun Wang, Yingjun Zhang
  • Substituted aminopyrimidine compounds and methods of use
    Patent number: 10751339
    Abstract: The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 25, 2020
    Assignees: SUNSHINE LAKE PHARMA CO., LTD., CALITOR SCIENCES, LLC
    Inventors: Ning Xi, Liang Wang, Xuejin Feng, Min Liao
  • Inhibitors of influenza virus replication, application methods and uses thereof
    Patent number: 10717732
    Abstract: The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: July 21, 2020
    Assignee: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun Zhang, Qingyun Ren, Changhua Tang, Xiaohong Lin, Junjun Yin, Kai Yi
  • SALTS OF PYRAZOLO[1,5-a]PYRIDINE DERIVATIVE AND USE THEREOF
    Publication number: 20200222376
    Abstract: The present invention provides salts of pyrazolo[1,5-?]pyridine derivative and use thereof. The invention also relates to a pharmaceutically acceptable composition comprising such salts and a method of using the salts and the pharmaceutically acceptable composition to prevent or treat a proliferative disorder or pulmonary fibrosis in a patient.
    Type: Application
    Filed: December 15, 2018
    Publication date: July 16, 2020
    Applicants: Sunshine Lake Pharma Co., Ltd., Calitor Sciences, LLC
    Inventors: Ning Xi, Mingming Sun
  • Vilazodone inclusion complexes, compositions and preparation thereof
    Patent number: 10688090
    Abstract: Disclosed herein are inclusion complexes comprising vilazodone or a pharmaceutically acceptable salt thereof and an inclusion material, compositions and pharmaceutical formulations comprising the inclusion complexes, and methods for preparing the inclusion complexes, compositions or pharmaceutical formulations.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: June 23, 2020
    Assignee: Sunshine Lake Pharma Co., Ltd.
    Inventors: Shuiwang Feng, Xin Huang, Jinsong You, Fangfang Huang
  • FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
    Publication number: 20200113879
    Abstract: A fused tricyclic compound and use thereof as a medicament, in particular as a medicament for the treatment and/or prevention of hepatitis B. Specifically, a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in specification. The compound also includes a Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.
    Type: Application
    Filed: June 2, 2018
    Publication date: April 16, 2020
    Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Xinchang LIU, Qingyun REN, Jianzhou HUANG, Zhimin XIONG, Jinfeng XIONG, You LI, Yang LIU, Zhifu ZOU, Guanghua YAN, Siegfried GOLDMANN, Yingjun ZHANG
  • INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF
    Publication number: 20200085822
    Abstract: The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.
    Type: Application
    Filed: December 14, 2017
    Publication date: March 19, 2020
    Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Changhua TANG, Qingyun REN, Junjun YIN, Kai YI, Yibo LEI, Yejun WANG, Yingjun ZHANG
  • INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF
    Publication number: 20200010472
    Abstract: A class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.
    Type: Application
    Filed: March 1, 2018
    Publication date: January 9, 2020
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Changhua TANG, Qingyun REN, Junjun YIN, Kai YI, Yibo LEI, Yejun WANG, Yingjun ZHANG
  • Inhibitors of influenza virus replication, application methods and uses thereof
    Patent number: 10501444
    Abstract: The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: December 10, 2019
    Assignees: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Qingyun Ren, Changhua Tang, Junjun Yin, Kai Yi, Yingjun Zhang
  • THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE
    Publication number: 20190352311
    Abstract: The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 21, 2019
    Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Wanjun TANG, Xinye YANG, Zheng GU, Chenlu LI, Zongyuan ZHANG, Zhifu WAN, Xiaojun WANG, Yingjun ZHANG
  • Sacubitril intermediate and preparation method thereof
    Patent number: 10479753
    Abstract: The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.
    Type: Grant
    Filed: August 26, 2018
    Date of Patent: November 19, 2019
    Assignee: SUNSHINE LAKE PHARMA CO., LTD
    Inventors: Lei Chen, Guodong Sun, Xiaodong Han, Shun Li, Jiebin Zeng, Zhongqing Wang, Zhonghua Luo
  • BOROSILICATE GLASS WITH HIGH CHEMICAL RESISTANCE AND APPLICATION THEREOF
    Publication number: 20190322569
    Abstract: The invention discloses a borosilicate glass with high chemical resistance and an application thereof. The borosilicate glass contains 0.25-4.0 wt % of Y2O3 based on the oxide. The borosilicate glass has a high chemical stability, a suitable linear thermal expansion coefficient and is suitable for use in the field of pharmaceutical packaging materials.
    Type: Application
    Filed: December 26, 2017
    Publication date: October 24, 2019
    Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Weiqiang HONG, Zhengshang ZHOU, Yong JIANG, Lianying ZHU, Xinqian HE, Hongxing HAN
  • LURASIDONE SOLID DISPERSION AND PREPARATION METHOD THEREOF
    Publication number: 20190321304
    Abstract: It relates to a lurasidone solid dispersion and a preparation method, wherein the method comprises melting treatment of a mixture containing lurasidone, a medicinal hot melt carrier, optionally an acidic regulator and plasticizer in order to obtain the solid dispersion described herein, and wherein the lurasidone is provided in a form of free base. The lurasidone solid dispersion obtained by the preparation method according to the example of the invention has the characteristics of high dissolution rate (dissolution rate can reach 30%-70%) in a partial neutral medium (e.g. pH6.0). The bioavailability of lurasidone solid dispersion increased significantly and the food effect of lurasidone solid dispersion prepared from the example decreased remarkably.
    Type: Application
    Filed: January 4, 2018
    Publication date: October 24, 2019
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yuzhen XU, Ning TIAN, Xin HUANG, Jinsong YOU, Fangfang HUANG
  • SALTS OF 2,6-DIMETHYLPYRIMIDONE DERIVATIVES AND USES THEREOF
    Publication number: 20190308939
    Abstract: Provided are salts of 2, 6-dimethylpyrimidone derivatives and uses thereof. Also provided are pharmaceutical compositions containing the salts.
    Type: Application
    Filed: July 19, 2017
    Publication date: October 10, 2019
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Runfeng LIN, Liang CHEN, Xiaojun WANG, Yingjun ZHANG, Jiancun ZHANG
  • Method and system of cultivating cordyceps
    Patent number: 10405527
    Abstract: The present invention relates to a system and method of cultivating Cordyceps, specifically, provided herein is a system of cultivating Cordyceps comprising: a Hepialus moth trapping device; a Hepialus moth eggs screening device, wherein the device is connected with the Hepialus moth trapping device; an ascospores-collecting device; a mycelia-preparing device; a conidia-preparing device; an infection device, wherein the device is connected with the ascospores-collecting device, the mycelia-preparing device and the conidia-preparing device; and a feeding device, wherein the device is connected with the Hepialus moth eggs screening device and the infection device. And also provided is a method of using the system to cultivate Cordyceps.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 10, 2019
    Assignees: SUNSHINE LAKE PHARMA CO., LTD, YICHANG SHANCHENGSHUIDU CORDYCEPS CO., LTD.
    Inventors: Wenjia Li, Zongyao Zhang, Quanping Li, Yanhua Lv, Zhengming Qian
  • DIARYL THIOETHER PIPERAZINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20190256482
    Abstract: The invention relates to a diaryl thioether piperazine compound, a preparation method and use thereof. Specifically, the compound is a compound of Formula (I), wherein HX is C10-20 fatty acid or pamoic acid.
    Type: Application
    Filed: June 15, 2017
    Publication date: August 22, 2019
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Xin LEI, Dongming LI, Zhonghua LUO, Bifei HE, Qian WANG
  • Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof
    Patent number: 10370380
    Abstract: The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceutical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease related to orexin receptors.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 6, 2019
    Assignee: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Yingjun Zhang, Chuanfei Jin, Ji Zhang
  • SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
    Publication number: 20190224197
    Abstract: The invention relates to the preparation and use of new aminopyrirnidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.
    Type: Application
    Filed: January 18, 2019
    Publication date: July 25, 2019
    Applicants: Sunshine Lake Pharma Co., Ltd., Calitor Sciences, LLC
    Inventors: Ning Xi, Liang Wang, Xuejin Feng, Min Liao
  • INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF
    Publication number: 20190194159
    Abstract: The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the manufacture of medicaments for treating of influenza.
    Type: Application
    Filed: August 29, 2017
    Publication date: June 27, 2019
    Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Changhua TANG, Qingyun REN, Junjun YIN, Kai YI, Yingjun ZHANG
  • INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF
    Publication number: 20190185456
    Abstract: The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 20, 2019
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Qingyun REN, Changhua TANG, Junjun YIN, Kai YI, Yingjun ZHANG