Abstract: The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject's pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject's pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject's pulse provides an estimate of the central systolic blood pressure of the subject.

Abstract: Embodiments of the present invention provide an improved transformation method whereby the peripheral pulse waveform is filtered to separate different phases which make up the waveform. The separate phases are transformed before being re-combined to provide an estimated intra-arterial transfer function. For example, in one embodiment the peripheral pulse waveform is filtered by a first high pass filter, and a copy of the peripheral pulse waveform filtered by a second high pass filter, having a different cut-off frequency. The two filtered waveforms may then be further processed, for example by being added back to original wave-form, and are then multiplexed together in a time division manner to provide a final waveform.

Abstract: The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject's pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject's pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject's pulse provides an estimate of the central systolic blood pressure of the subject.

Abstract: Inflatable blood pressure cuff assemblies include an inflatable elongate cuff member having opposing long edges and opposing short edge portions with a fluid chamber therein and a resilient support sleeve with at least one rib support member, the sleeve attached to a respective one of the opposing short edge portions of the inflatable elongate cuff member. The sleeve may be configured with a sensor chamber and a cable routing channel. Related systems and methods of fabricating cuff assemblies and resilient support sleeves are also described.

Abstract: Inflatable blood pressure cuff assemblies include an inflatable elongate cuff member having opposing long edges and opposing short edge portions with a fluid chamber therein and a resilient support sleeve attached to a respective one of the opposing short edge portions of the inflatable elongate cuff member. The sleeve may be configured with a sensor chamber and a cable routing channel. Related systems and methods of fabricating cuff assemblies and resilient support sleeves are also described.