Patents Assigned to Suppremol GmbH
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Patent number: 11266708Abstract: The present invention relates to novel formulations of soluble Fc receptors and especially to formulations containing high concentrations of soluble Fc?RIIB receptor. The invention further relates to the use of such formulations as pharmaceutical compounds for the treatment of autoimmune diseases, infections and other conditions where the immune system is involved.Type: GrantFiled: January 4, 2019Date of Patent: March 8, 2022Assignee: SUPPREMOL GMBHInventors: Peter Sondermann, Thomas Pohl
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Patent number: 10866247Abstract: The present invention relates in essence to an in vitro method for determining the stability, such as the shelf stability; stability over time; shelf life of a composition which comprises or essentially consists of soluble human Fc gamma receptor IIA, MB, IIIA and/or 1 MB, said method comprising the steps of contacting a surface comprising human Fc gamma receptor IIA, MB, IIIA and/or 1 MB with a set amount of aggregated human IgG; contacting said surface comprising human Fc gamma receptor IIA, MB, IIIA and/or 1 MB with a set amount of said composition of soluble human Fc gamma receptor IIA, MB, IIIA and/or 1 MB; determining the amount of aggregated human IgG which is bound to said surface comprising said human Fc gamma receptor IIA, MB, IIIA and/or 1 MB, and comparing the amount of aggregated human IgG which is bound to said surface as determined in step (c) with a reference value and (thereby) determining the stability [shelf stability; stability over time; shelf life] of said composition which comprises orType: GrantFiled: August 1, 2014Date of Patent: December 15, 2020Assignee: SUPPREMOL GMBHInventors: Peter Sondermann, Thomas Pohl, Dominik Ter Meer
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Patent number: 10730946Abstract: Disclosed herein are recognition molecules that bind with a first binding domain to the Fc epsilon receptor (Fc?eR) and with a second binding domain to the Fc gamma receptor IIB (FcyRIIB), as well as uses for such recognition molecules.Type: GrantFiled: August 13, 2015Date of Patent: August 4, 2020Assignee: SUPPREMOL GMBHInventors: Anna Carle, Carolin Direnberger, Peter Sondermann, Martina Mueller, Nicole Rieth, Thomas Pohl
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Patent number: 10669324Abstract: The present invention relates to a nucleic acid sequence which encodes a protein of SEQ ID NO: 1; a vector comprising said nucleic acid sequence and a host cell comprising said nucleic acid sequence or said vector. The present invention also relates to a protein obtained or obtainable by expression of said nucleic acid sequence or said vector in a host cell. Furthermore, the present invention relates to a protein encoded by a nucleic acid sequence of SEQ ID NO: 6. Additionally comprised by the present invention are pharmaceutical compositions and a method of manufacturing the same.Type: GrantFiled: October 30, 2013Date of Patent: June 2, 2020Assignee: SUPPREMOL GMBHInventors: Peter Sondermann, Dominik Ter Meer, Thomas Pohl, Reno Winter, Uwe Jacob
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Patent number: 10407499Abstract: The present invention provides an anti-FcyRIIB antibodies which, in comparison to prior art antibodies, markedly increase ITIM phosphorylation of FcyRIIB and can thus be used for the treatment or prophylaxis of autoimmune diseases.Type: GrantFiled: August 13, 2014Date of Patent: September 10, 2019Assignee: SUPPREMOL GMBHInventors: Peter Sondermann, Thomas Pohl, Dominik Ter Meer, Anna Carle, Daniela Ehehalt, Nicole Rieth
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Patent number: 10226504Abstract: The present invention relates to novel formulations of soluble Fc receptors and especially to formulations containing high concentrations of soluble Fc?RIIB receptor. The invention further relates to the use of such formulations as pharmaceutical compounds for the treatment of autoimmune diseases, infections and other conditions where the immune system is involved.Type: GrantFiled: April 16, 2014Date of Patent: March 12, 2019Assignee: SUPPREMOL GMBHInventors: Peter Sondermann, Thomas Pohl
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Patent number: 10028998Abstract: The present invention relates to a method for treating or preventing either one or both of an inflammatory disease and an autoimmune disease in a patient, wherein the method comprises providing a pharmaceutical composition containing a therapeutically effective amount of soluble Fc?R; administering said composition to a patient, followed by a safety period of several weeks, followed by a subsequent treatment cycle of at least two weekly administrations, wherein said therapeutically effective amount is effective to treat or prevent said disease in said patient. The present invention also provides a pharmaceutical composition in the form of a multiple-dosage-kit which contains sufficient amounts of administration doses of soluble Fc?R for effectively treating or preventing inflammatory diseases and/or autoimmune diseases in a patient.Type: GrantFiled: October 30, 2012Date of Patent: July 24, 2018Assignee: SUPPREMOL GMBHInventors: Peter Buckel, Peter Sondermann, Sascha Tillmanns, Ingrid Berger
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Patent number: 9981009Abstract: The invention generally relates to the field of biotechnology and medicine. It provides an agent, a pharmaceutical composition and a kit for treatment of autoimmune bullous diseases (AMDB). More specifically, the invention relates to the use of a soluble Fc gamma receptor for treating AMDB, and a pharmaceutical composition and a kit comprising said receptor. It further involves a method of treatment of AMDB.Type: GrantFiled: October 16, 2013Date of Patent: May 29, 2018Assignee: SUPPREMOL GMBHInventors: Ralf Ludwig, Peter Sondermann, Dominik Ter Meer
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Publication number: 20160095895Abstract: The present invention relates to novel formulations of soluble Fc receptors and especially to formulations containing high concentrations of soluble Fc?RIIB receptor. The invention further relates to the use of such formulations as pharmaceutical compounds for the treatment of autoimmune diseases, infections and other conditions where the immune system is involved.Type: ApplicationFiled: April 16, 2014Publication date: April 7, 2016Applicant: Suppremol GMBHInventors: Peter Sondermann, Thomas Pohl
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Publication number: 20140120080Abstract: The present invention relates to a method for treating or preventing either one or both of an inflammatory disease and an autoimmune disease in a patient, wherein the method comprises providing a pharmaceutical composition containing a therapeutically effective amount of soluble Fc?R; administering said composition to a patient, followed by a safety period of several weeks, followed by a subsequent treatment cycle of at least two weekly administrations, wherein said therapeutically effective amount is effective to treat or prevent said disease in said patient. The present invention also provides a pharmaceutical composition in the form of a multiple-dosage-kit which contains sufficient amounts of administration doses of soluble Fc?R for effectively treating or preventing inflammatory diseases and/or autoimmune diseases in a patient.Type: ApplicationFiled: October 30, 2012Publication date: May 1, 2014Applicant: SuppreMol GmbHInventors: Peter Buckel, Peter Sondermann, Sascha Tillmanns, Ingrid Berger
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Publication number: 20130089893Abstract: A soluble multimeric protein or polypeptide is disclosed that is able to inhibit interaction of leukocyte Fc? receptors (Fc?R) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more linked Fc binding regions, at least one of which is derived from an Fc?R type receptor and, particularly, Fc?RIIa. Also described are polynucleotide molecules encoding the protein or polypeptide and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease.Type: ApplicationFiled: December 6, 2012Publication date: April 11, 2013Applicant: SUPPREMOL GMBHInventor: Suppremol GMBH
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Patent number: 8354109Abstract: A soluble multimeric protein or polypeptide is disclosed that is able to inhibit interaction of leukocyte Fc? receptors (Fc?R) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more linked Fc binding regions, at least one of which is derived from an Fc?R type receptor and, particularly, Fc?RIIa. Also described are polynucleotide molecules encoding the protein or polypeptide and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease.Type: GrantFiled: June 13, 2007Date of Patent: January 15, 2013Assignee: Suppremol GmbHInventors: Phillip Mark Hogarth, Bruce David Wines