Abstract: A combination hole punching and book binding machine having a worktable and an electric motor disposed fixedly thereon, a left changeover panel and a right changeover panel being symmetrically disposed on the worktable, a press knife assembly being disposed between the left changeover panel and the right changeover panel. By driving the left changeover panel and the right changeover panel, the press knife assembly can be combined as needed. Meanwhile, the quantity of the press knives is regulated, and thereby the number, pass, and pitch of holes is adjusted.