Abstract: The present disclosure describes combination therapies for breast cancer comprising an oligonucleotide toll-like receptor 9 agonist and a PD-1 antagonist. In particular, the present disclosure describes combinations of a CpG-C type oligonucleotide and an anti-PD-1 antibody for the treatment of breast cancer. The combination may further comprise a taxane chemotherapeutic agent, in the presence or absence of a corticosteroid.
Type:
Application
Filed:
April 13, 2021
Publication date:
October 14, 2021
Applicants:
Surefire Medical, Inc. d/b/a TriSalus Life Sciences, The Regents of the University of California, H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
Robert S. Janssen, Erick Gamelin, Laura J. Esserman, Amy Jo Chien, Hetem Soliman