Abstract: An automatic injector training device comprises an outer structure having i) a rearward end, ii) a forward end arranged to be engaged with an injection site of the user, and iii) an intermediate portion. A manually movable actuating member is movable between a storage position and an activated position by being manually depressed by the user. A prod member is movable within the outer structure between a retracted position and an outwardly extending position when the actuating member is manually moved between the storage position to the activated position. A spring member is disposed within the outer structure and arranged so as to move the prod member from the outwardly extending position to the retracted position when the actuating member is moved from the activated position to the storage position.

Abstract: A reloadable automatic injector comprises a reusable power pack assembly for effectuating multiple injection operations. The power pack assembly includes an outer body and an energy releasing assembly disposed within the body. The energy releasing assembly is capable of providing multiple energy releasing strokes. A disposable cartridge assembly is provided which is engageable with the power pack assembly and forms an elongate injection assembly therewith. The cartridge assembly is adapted to receive energy from the power pack during one of the energy releasing strokes. The cartridge assembly includes a housing in which a charge of medicament and a needle is contained. A plunger is disposed within the housing for forcing the medicament through the needle.

Abstract: A disposable, automatic, injector is disclosed which allows self-administration of a medicament to be injected subcutaneously. The injector comprises a barrel (1) with an inner chamber bounded by a liner (2). A first piston (4) and a second piston (11) are provided which may slide within the chamber with a fluid-tight seal with the liner (2). The second piston (11) carries an injection needle (13). A drive means, comprising a compression spring (5) and a releasable retaining collet (6), is provided to act on the first piston (4) to drive it towards the second piston (11). In operation, the drive means urges the first piston towards the second (11). The injection fluid, initially stored between the first and second pistons is incompressible and causes the second piston (11) to move until the needle (13) projects from the end of the barrel (1).

Abstract: A rectal administrator comprises a body having an administrative portion adapted to be inserted into a subject's rectum. A charge of medicament is disposed within the body, and the administrative portion has at least one passage through which the medicament can exit the body. A plunger is disposed in the body and is movable from a first position to a second position within the body to dispense the medicament from the body through the at least one passage. A releasable energy source is mounted within the body so as to be released in response to a predetermined actuating procedure. The releasable energy source moves the plunger from the first position to the second position to dispense the medicament from the body through the at least one passage when released in response to the predetermined actuating procedure.

Abstract: An injection device comprises a plastic or metal container adapted to contain a charge of medicament, the container has at least an inner surface thereof coated with polyparaxylylene. A needle is cooperable with the container so as to be communicable with the medicament and provides a passage through which the medicament can be forced into the flesh of an individual. A plunger is disposed in the container in slidably sealed relation with the polyparaxylylene coating provided on the inner surface of the container. The plunger is movable through the container toward a generally forward end thereof to force the medicament through the needle and into the flesh of the individual.

Abstract: A method and device for obtaining electrical heart activity of an individual in a form capable of producing a twelve-lead electrocardiogram of an individual. The device includes a portable electrode support having an array of six non-adhesive precordial electrodes fixed thereon at predetermined positions within the array which correspond with the Wilson precordial leads for the individual. The device also includes a right arm electrode, a left arm electrode, a left leg electrode and circuitry for converting the electrical heart activity of the individual obtained by said electrodes into a form capable of producing a twelve-lead electrocardiogram. The method includes the steps of applying the left leg, left arm and right arm electrode to the skin of the individual at locations such that the circuitry can be electrically operable to obtain leads I, II, III, AVR, AVL, and AVF therefrom.

Abstract: An automatic injector having a needle which is driven out of a body of the injector automatically by drive means also has an associated protective, or sharps, assembly. The sharps assembly has a cover member adapted to cover the needle after the injector has been used. The assembly is operative to provide relative movement between the injection needle and the cover member after injection so that the cover member covers the needle after use. The cover member is preferably actuated automatically so that the user never sees the needle.

Abstract: An autoinjector converted from an intramuscular to a subcutaneous mode of injection comprising a housing having a medicament cartridge assembly mounted within the housing means in a storage position for movement out of the storage position and a releasable stressed spring assembly for moving the medicament cartridge assembly means out of the storage position. The stressed spring assembly is operable in response to a manual actuating procedure which does not require compression of the subcutaneous tissue to effect an intramuscular mode of injection by moving the hypodermic needle of the cartridge assembly outwardly of the housing into the muscle tissue at the injection site of a user and a major portion of the liquid medicament of the cartridge assembly outwardly through the hypodermic needle into the muscle tissue of the user.

Abstract: A medicament container assembly for an autoinjector having a power assembly actuatable to cause a power stroke in cooperating relation with said medicament container assembly. The medicament container assembly comprises a container having a forward end, a hypodermic needle having a sharpened end, and first and second liquid medicaments.

Abstract: An autoinjector particularly suited to be carried on the person of a user comprising a housing defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen including a housing body assembly of elongated generally cylindrical configuration and a separate housing cap structure of elongated generally cylindrical configuration having an elongated clip thereon. The housing cap structure is detachably secured to the housing body assembly in open ended telescopic relation with an opposite end portion thereof preferably by a childproof connection. A medicament cartridge assembly is mounted in a storage position within a forward end of an interior chamber within the housing body assembly and a releasable stressed spring assembly is carried by the housing body assembly adjacent the rearward end thereof.

Abstract: A stressed spring assembly for providing an operative stroke in cooperating relation with a medicament cartridge assembly of an auto-injector so as to inject a liquid medicament of the medicament cartridge assembly through a hypodermic needle of the medicament cartridge assembly into an injection site of the user. The stressed spring assembly includes a cap structure serving the plural purposes of (1) facilitating the securement of the cap structure and remainder of the auto-injection with the user's pocket, (2) alleviating the likelihood of an unwanted release of the releasable mechanism of the stressed spring assembly with a resultant unwanted movement of the hypodermic needle and an unwanted movement of the liquid medicament outwardly of the hypodermic needle by requiring two different manual movements for its removal, and (3) protecting against an unwanted contact with the hypodermic needle while in extended operative position after withdrawal from the injection site.

Abstract: A method of treating a patient with liquid medicament under circumstances where intravenous injection is not practical but the fast response time of an intravenous injection is desirable, including the treatment of individuals undergoing heart attack symptoms with t-PA.

Abstract: The absorption rate of proteins with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, e.g. hydroxylamine or a salt thereof.

Abstract: A package comprising a package container structure having an open end leading into an interior chamber therein, a package lid structure mounted over the open end of the package container structure in generally sealed relation with the interior chamber thereof so as to be moved into opening relation thereto, and a device for use with a medicament vial disposed within the sealed interior chamber. The device and package container structure have interengageable elements disposed out of interengagement when the device is disposed within the sealed interior chamber operable when the package lid structure is moved into opening relation and the device is moved out of the open end of the interior chamber to be moved into interengagement. The device and package container structure with the interengaging elements thereof interengaged provide a generally sealed interior space including the interior chamber within which a medicament vial is contained in cooperating relation with the device.

Abstract: A device for measuring electrical activity of the heart of a user. The portable device includes structure for receiving at least two leads of electrical activity of the heart of the user. This information is amplified, and coupled to a memory to produce audio signals of a form suitable for transmission over telephone lines in response to input signals. These input signals can be either from the memory or from the output of the amplifier, depending on the mode being commanded. A control structure commands the mode of operation. Live mode allows the acquired input to pass directly to the speaker, to be passed over the telephone lines. Recording mode records the input. Time interval mode records the entire capacity of the memory once. Rolling mode continually acquires and displaces other information that was previously in place.

Abstract: A heart monitoring device for use under emergency conditions including a portable housing, a pair of electrodes and a pair of electrical wires connecting the electrodes to the housing and to an electrical circuit carried therein. The electrodes are usable in two modes. One mode is a precordial mode wherein the electrodes are mounted on the exterior of the housing in spaced positions fixed with respect to the housing in commonly outwardly facing relation so as to be conveniently engageable with the skin of the chest of a user by manually engaging the housing and moving it with the electrodes fixed thereto into housing retained operative positions on the chest skin. The second mode is a non-precordial mode wherein the electrodes are removed from the housing and, preferably, self-retained within the armpits.

Abstract: A package containing (1) t-PA, (2) methylamine or a non-toxic salt thereof and (3) hydroxylamine or a non-toxic salt thereof, the amount of hydroxylamine or non-toxic salt thereof being sufficient to increase the absorption in the blood of the t-PA when it is administered non-intravascularly to a mammal and the amount of methylamine or non-toxic salt thereof being sufficient to reduce the amount of hydroxylamine or non-toxic salt thereof required to obtain the increased absorption of t-PA and a method for intramuscularly administering the same.