Abstract: A composition for topical application to a mucosal body site contains a combination of L-arginine, niacin, and a cooling compound. In one embodiment the composition contains from about 2% to about 7% by weight of a nitric oxide releasing substance selected from the group consisting of L-arginine, L-arginine salts and L-arginine derivatives. The composition also contains from about 0.05% to about 0.5% by weight niacin, and from about 0.1% to about 1% by weight of at least one compound capable of providing a sensation of cooling to the body site of application.

Abstract: A composition for topical application to a mucosal body site contains a combination of L-arginine, niacin, and a cooling compound. In one embodiment the composition contains from about 2% to about 7% by weight of a nitric oxide releasing substance selected from the group consisting of L-arginine, L-arginine salts and L-arginine derivatives. The composition also contains from about 0.05% to about 0.5% by weight niacin, and from about 0.1% to about 1% by weight of at least one compound capable of providing a sensation of cooling to the body site of application.