Abstract: The present disclosure provides glycosylated oligopeptides having the sequence Palmitoyl-X1-Lys-X2-X3-Lys-X4-OH, where: X1 is: absent, Ser having a glycosylated side chain, or Asn having a glycosylated side chain; X2 is: Thr, Thr having a glycosylated side chain, Asn having a glycosylated side chain, or Ser having a glycosylated side chain; X3 is: Thr, or Thr having a glycosylated side chain; X4 is: Ser, or Ser having a glycosylated side chain. At least one of X1, X2, X3 and X4 is an amino acid having a glycosylated side chain. Each glycosylated side chain is, independently, glycosylated with a carbohydrate selected from the group consisting of: glucose, N-acetyl-glucosamine, galactose, N-acetyl-galactosamine, mannose, maltose, lactose, rhamnose, cellobiose, xylose, and fucose. Each hydroxyl group on the carbohydrate is, independently, OH or acetylated.
Type:
Grant
Filed:
December 9, 2014
Date of Patent:
January 2, 2018
Assignee:
Sussex Research Laboratories Inc.
Inventors:
Kenneth Brady Clark, Remmick So, Vanja Vukic