Abstract: The invention relates to a method for the production of single alpha chain collagens and an isolated or purified product comprising single alpha chain collagens.

Abstract: The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.

Abstract: A glass laminate structure is disclosed with a first and a second glass ply and a printed polymer ply interposed between the first and second glass plies, the printed polymer ply may be of PVB or PET having nanoparticle-containing ink adhered to at least a portion of a surface. Optionally there may be at least one further polymer ply which may be of PVB, PVA, COP or TPU. The nanoparticle-containing ink may contain electrically conductive nanoparticles, especially silver nanoparticle-containing ink. Also disclosed is a process for producing such a glass laminate structure.

Abstract: This invention relates to a method and apparatus for the early detection and monitoring of colorectal cancer via the sampling of a patient's blood.

Abstract: The present invention is related to highly oxygenated nanoribbons and highly microporous carbon (mPC) produced by the oxidation of a series of carbon blacks in nitric acid followed by fast and slow pyrolysis, respectively. New porous carbons according to the invention does not need to be activated by strong alkaline activators, for example, KOH and NaOH. The best prepared mPC showed a high capacity for carbon dioxide capture of 1 to 3.9 mmol/g at pressures between 0.15 and 1 bar and 25° C.

Abstract: The present invention relates to a platform that may be utilised in the field of biosensors. According to the present invention there is a method of manufacturing a platform for use in bio-sensing applications comprising the steps of: a) providing a substrate having electrodes thereon; b) performing an overprinting step by overprinting the electrodes with a precursor solution; c) performing a drying step to dry the precursor solution to form a print layer on the electrodes; d) performing a further overprinting step by overprinting the print layer with a precursor solution to increase the print layer thickness; e) performing a transformation step to at least partially transform the print layer from a first substance to a second substance different to the first substance.

Abstract: The present invention relates to porous carbon spheres via one-step non-catalytic and activation-free chemical vapor deposition method possessing a large volume of ultra-micropores. The ultra-micropore structure allows for with good cyclic stability, easy regeneration, favorable selectivity, and rapid sorption kinetics resulting in high capacity of CO2 capture at atmospheric and low pressures.

Abstract: The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active against at least one gene encoding a cancer promoting or sustaining protein such as an oncogene, a chemo-resistant gene or a metabolic gene; siRNA cassette encoding at least one siRNA active against said gene; a bacterial cell with said siRNA cassette integrated within the bacterial chromosome; a method of treating cancer, particularly but not exclusively prostate, breast or colorectal cancer, employing the use of said bacterial cell with a chromosomally integrated siRNA cassette; and use of said bacterial cell with a chromosomally integrated siRNA cassette to treat said cancer.

Abstract: The invention concerns a method of making a synthetic, biodegradable, bone graft comprising a three-dimensional porous structure; a formulation of constituents for use in said method; a synthetic, biodegradable bone graft produced by said method; and a method of surgery comprising use of said bone graft.

Abstract: A gas flow indicator for medical equipment is described which is configured to provide an audible indication of gas flow. The medical equipment may be in the form of a respiratory care device, an airway management device, a heat moisture exchanger, an oxygen enrichment device or a breathing mask.

Abstract: The invention relates to a method for the production of single alpha chain collagens and an isolated or purified product comprising single alpha chain collagens.

Abstract: This invention relates to a method and apparatus for the early detection and monitoring of colorectal cancer via the sampling of a patient's blood.

Abstract: A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation Endproducts (RAGE) linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosis or polycystic ovary syndrome. Novel cell binding agents, pharmaceutical compositions and methods are also described.

Abstract: A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation End (RAGE) products linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosis or polycystic ovary syndrome. Novel cell binding agents, pharmaceutical compositions and methods are also described and claimed.

Abstract: A method of managing a microgrid and control system is provided, in which the virtual resistance control gains (in ?? frame) of each respective inverter is dynamically adjusted based on a variable related to the available power from each of a plurality of renewable distributed generators.

Abstract: The present invention relates to a valve arrangement particularly, but not exclusively, for use in dampers to control compression and optionally rebound properties of a shock absorber wherein the valve arrangement comprising a valve body having a first and second fluid flow pathway for enabling fluid flow from an upstream to a downstream location and the valve arrangement further comprises a plurality of operational configurations for controlling the flow rate of fluid flow.

Abstract: A micro-grid energy management system is provided which can operate and regulate power, voltage, frequency and phase to a load in both grid-connected and islanded mode, obviating the need for switching between control paradigms.

Abstract: A glass laminate structure is disclosed with a first and a second glass ply and a printed polymer ply interposed between the first and second glass plies, the printed polymer ply may be of PVB or PET having nanoparticle-containing ink adhered to at least a portion of a surface. Optionally there may be at least one further polymer ply which may be of PVB, PVA, COP or TPU. The nanoparticle-containing ink may contain electrically conductive nanoparticles, especially silver nanoparticle-containing ink. Also disclosed is a process for producing such a glass laminate structure.

Abstract: A method of indicating the presence of a bacterial infection in a biological sample is provided. The method detects a marker for infection by providing a device, the device including a biosensor, an interaction arising between the biosensor and the marker when the marker is present in the biological sample. Contacting at least a part of the biological sample with the biosensor of the device, therefore, provides analysis of the biological sample with respect to the marker by detecting for the interaction between the biosensor and the marker. A preferred marker is the enzyme amylase.

Abstract: The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active against at least one gene encoding a cancer promoting or sustaining protein such as an oncogene, a chemo-resistant gene or a metabolic gene; siRNA cassette encoding at least one siRNA active against said gene; a bacterial cell with said siRNA cassette integrated within the bacterial chromosome; a method of treating cancer, particularly but not exclusively prostate, breast or colorectal cancer, employing the use of said bacterial cell with a chromosomally integrated siRNA cassette; and use of said bacterial cell with a chromosomally integrated siRNA cassette to treat said cancer.