Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: A noninvasive method for measuring biological materials which is configured to enable an immediate diagnosis is used in an analytical absorption spectroscopy apparatus including a broadly tunable infrared laser oscillation device, a photodetection device, and an analysis device. The method applies an infrared ray to an analyte organism while tuning the wavelength from the laser oscillation device with or without the ray going through a nonlinear optical device. The photodetection device detects a reflected beam, a transmitted beam, or a scattering beam from the organism or ultrasound generated within the organism by using the detection device. The analysis device analyzes a signal input by the photodetection device.