Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
September 2, 2010
Publication date:
December 30, 2010
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jiménez, Angela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
Abstract: The present invention relates to methods and compositions for the treatment and/or the prevention of conditions related to high levels of expression and/or activity of the transient receptor potential vanilloid-1 (TRPV1). Amongst others, the conditions to be treated are eye conditions such as discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses, dry eyes and diabetic retinopathy.
Type:
Application
Filed:
October 20, 2006
Publication date:
November 11, 2010
Applicant:
SYLENTIS S.A.U.
Inventors:
Maria del Carmen Acosta Boj, Juana Gallar Martinez, Angela Sesto Yague, Carlos Belmonte Martinez, Ana Isabel Jimenez Anton, Maria Concepcion Jimenez Gomez
Abstract: Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
Type:
Grant
Filed:
September 20, 2007
Date of Patent:
October 5, 2010
Assignee:
Sylentis S.A.U.
Inventors:
Ana I. Jiménez, Irene Gascón, María Concepción Jiménez, José P. Román, Angela Sesto
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
September 21, 2009
Publication date:
January 28, 2010
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Grant
Filed:
February 22, 2006
Date of Patent:
September 22, 2009
Assignee:
Sylentis S.A.U.
Inventors:
Ana I. Jiménez, Angela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
July 9, 2008
Publication date:
April 23, 2009
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
July 9, 2008
Publication date:
April 23, 2009
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
July 9, 2008
Publication date:
April 16, 2009
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
July 9, 2008
Publication date:
April 16, 2009
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
July 9, 2008
Publication date:
April 16, 2009
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
Type:
Application
Filed:
July 9, 2008
Publication date:
April 16, 2009
Applicant:
Sylentis S.A.U
Inventors:
Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
Abstract: Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
Type:
Application
Filed:
September 20, 2007
Publication date:
October 9, 2008
Applicant:
Sylentis S.A.U.
Inventors:
Ana I. Jimenez, Irene Gascon, Maria Concepcion Jimenez, Jose P. Roman, Angela Sesto