Abstract: A peptide is described herein that has: (i) a simple structure compared to existing natural human erythropoietin, thus capable of easily passing through a tissue-blood barrier, (ii) excellent bioactivity with respect to cell-protecting activity, (iii) a low manufacturing cost, thus being economically advantageous, and (iv) no side effects on cell proliferation. Also, a pharmaceutical composition comprising the erythropoietin-derived peptide described herein as an active ingredient is described. The pharmaceutical composition may be used for preventing or treating cell damage-related illnesses, such as stroke, mechanical damage or ischemic damage to the nervous system, myocardial infarction, retinal damage, and diabetes. Also, the described pharmaceutical composition may be used for preventing cell damage.
Type:
Grant
Filed:
July 7, 2022
Date of Patent:
March 18, 2025
Assignee:
SYLUS CO., LTD.
Inventors:
Che il Moon, Seung Jun Yoo, Chang-Hun Lee, So Yeon Kim, Deok Ho Lee
Abstract: Provided is a composition for accelerating cell proliferation, including an erythropoietin-derived peptide as an active ingredient. Due to having a simpler structure than that of the existing natural human erythropoietin, the composition easily passes through the tissue-blood barrier, exhibits excellent cell protective activity, does not cause side effects of cell proliferation, and improves a hematopoietic function. Accordingly, the composition is used in the treatment or prevention of an anemic disorder.
Type:
Grant
Filed:
August 21, 2019
Date of Patent:
May 21, 2024
Assignee:
SYLUS CO., LTD.
Inventors:
Che Il Moon, So Yeon Kim, Seung Jun Yoo, Bong Ki Cho
Abstract: Peptides are easy to pass through a tissue-blood barrier, have excellent physiological activity in the protective activity of cells, and have an economic advantage due to low production costs. In addition, since there is no side effect of cell proliferation, a pharmaceutical composition containing a peptide of an aspect as an active ingredient can be usefully used in the treatment or prevention of neurological disorders and degenerative brain diseases.
Type:
Grant
Filed:
May 26, 2021
Date of Patent:
January 31, 2023
Assignees:
SYLUS CO., LTD, Daegu Gyeongbuk Institute of Science and Technology
Abstract: Peptides are easy to pass through a tissue-blood barrier, have excellent physiological activity in the protective activity of cells, and have an economic advantage due to low production costs. In addition, since there is no side effect of cell proliferation, a pharmaceutical composition containing a peptide of an aspect as an active ingredient can be usefully used in the treatment or prevention of neurological disorders and degenerative brain diseases.
Type:
Application
Filed:
May 26, 2021
Publication date:
December 2, 2021
Applicants:
SYLUS CO., LTD, Daegu Gyeongbuk Institute of Science and Technology
Abstract: Provided is a composition for accelerating cell proliferation, including an erythropoietin-derived peptide as an active ingredient. Due to having a simpler structure than that of the existing natural human erythropoietin, the composition easily passes through the tissue-blood barrier, exhibits excellent cell protective activity, does not cause side effects of cell proliferation, and improves a hematopoietic function. Accordingly, the composition is used in the treatment or prevention of an anemic disorder.
Type:
Application
Filed:
August 21, 2019
Publication date:
November 4, 2021
Applicant:
SYLUS CO., LTD.
Inventors:
Che Il MOON, So Yeon KIM, Seung Jun YOO, Bong Ki CHO
Abstract: A peptide is described herein that has: (i) a simple structure compared to existing natural human erythropoietin, thus capable of easily passing through a tissue-blood barrier, (ii) excellent bioactivity with respect to cell-protecting activity, (iii) a low manufacturing cost, thus being economically advantageous, and (iv) no side effects on cell proliferation. Also, a pharmaceutical composition comprising the erythropoietin-derived peptide described herein as an active ingredient is described. The pharmaceutical composition may be used for preventing or treating cell damage-related illnesses, such as stroke, mechanical damage or ischemic damage to the nervous system, myocardial infarction, retinal damage, and diabetes. Also, the described pharmaceutical composition may be used for preventing cell damage.
Type:
Grant
Filed:
August 26, 2019
Date of Patent:
October 20, 2020
Assignee:
SYLUS CO., LTD.
Inventors:
Che il Moon, Seung Yoo, Chang-Hun Lee, So Kim, Deok Lee