Abstract: Disclosed is an infective lambdoid bacteriophage which includes a protein construct comprising a genetically modified major tail protein truncated at its carboxy terminus, and a target molecule peptide bonded to the carboxy terminus of the tail protein. Also disclosed are nucleic acids encoding the construct and methods of detecting a molecule-of-interest in a solution and of detecting a cell which produces a molecule-of-interest.
Type:
Grant
Filed:
August 31, 1994
Date of Patent:
July 22, 1997
Assignee:
SymBioTech, Inc.
Inventors:
Bryan L. Ray, Edmund C. C. Lin, Roberto Crea