Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.
Type:
Grant
Filed:
March 27, 2009
Date of Patent:
September 30, 2014
Assignee:
Symic Biomedical, Inc.
Inventors:
Alyssa Panitch, John E. Paderi, Kinam Park, Katherine Stuart, Steve Higbee