Abstract: This invention relates to anti-TIM-3 antibodies and antibody compositions and their use in enhancing immunity in a patient, e.g., to treat cancer.
Type:
Application
Filed:
May 11, 2022
Publication date:
April 6, 2023
Applicant:
SYMPHOGEN A/S
Inventors:
Trine LINDSTED, Torben GJETTING, Gunther Roland GALLER, Monika GAD, Michael Monrad GRANDAL, Klaus KOEFOED, Michael KRAGH, Ivan David HORAK, Thomas BOUQUIN, Mikkel Wandahl PEDERSEN
Abstract: This invention relates to anti-NKG2A antibodies and methods of using them in enhancing immunity in a patient in need thereof and in treating cancer.
Type:
Application
Filed:
May 31, 2022
Publication date:
December 8, 2022
Applicant:
SYMPHOGEN A/S
Inventors:
Randi Westh Hansen, Franziska Katharina Uhlenbrock, Nikolaj Dietrich, Anne Worsaae, Michael Monrad Grandal
Abstract: This invention relates to combination therapies targeting two or all of PD-1, TIM-3, and LAG-3 using antibodies specific for these targets in patients who are in need of enhanced immunity. Also included in the invention are compositions useful in the therapies. The therapies are useful in treating diseases such as cancers.
Type:
Application
Filed:
June 7, 2022
Publication date:
December 1, 2022
Applicant:
SYMPHOGEN A/S
Inventors:
Trine Lindsted, Michael Monrad Grandal, Eva Maria Carlsen Melander, Camilla Fröhlich, Mikkel Wandahl Pedersen, Michael Kragh, Johan Lantto, Monika Gad, Ivan David Horak
Abstract: This invention relates to anti-LAG-3 antibodies and methods of using them in treating diseases and conditions that benefit from modulating LAG-3 activity, e.g., cancer.
Type:
Application
Filed:
June 7, 2022
Publication date:
November 17, 2022
Applicant:
SYMPHOGEN A/S
Inventors:
Michael Monrad GRANDAL, Vikram Kjøller BHATIA, Torben GJETTING, Camilla FRÖHLICH, Gunther Roland GALLER, Michael KRAGH, Ivan David HORAK, Thomas BOUQUIN, Mikkel Wandahl PEDERSEN
Abstract: This invention relates to anti-LAG-3 antibodies and methods of using them in treating diseases and conditions that benefit from modulating LAG-3 activity, e.g., cancer.
Type:
Grant
Filed:
October 13, 2017
Date of Patent:
July 19, 2022
Assignee:
Symphogen A/S
Inventors:
Michael Monrad Grandal, Vikram Kjøller Bhatia, Torben Gjetting, Camilla Fröhlich, Gunther Roland Galler, Michael Kragh, Ivan David Horak, Thomas Bouquin, Mikkel Wandahl Pedersen
Abstract: This invention relates to anti-TIM-3 antibodies and antibody compositions and their use in enhancing immunity in a patient, e.g., to treat cancer.
Type:
Grant
Filed:
April 11, 2017
Date of Patent:
July 19, 2022
Assignee:
Symphogen A/S
Inventors:
Trine Lindsted, Torben Gjetting, Gunther Roland Galler, Monika Gad, Michael Monrad Grandal, Klaus Koefoed, Michael Kragh, Ivan David Horak, Thomas Bouquin, Mikkel Wandahl Pedersen
Abstract: This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-lactivity, e.g., cancer.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
June 14, 2022
Assignee:
Symphogen A/S
Inventors:
Johan Lantto, Thomas Bouquin, Klaus Koefoed, Torben Gjetting, Vikram Kjoller Bhatia, Monika Gad, Gunther Roland Galler, Camilla Frohlich
Abstract: This invention relates to anti-LAG-3 antibodies and methods of using them in treating diseases and conditions that benefit from modulating LAG-3 activity, e.g., cancer.
Type:
Application
Filed:
October 13, 2017
Publication date:
February 24, 2022
Applicant:
SYMPHOGEN A/S
Inventors:
Michael Monrad GRANDAL, Vikram Kjøller BHATIA, Torben GJETTING, Camilla FRÖHLICH, Gunther Roland GALLER, Michael KRAGH, Ivan David HORAK, Thomas BOUQUIN, Mikkel Wandahl PEDERSEN
Abstract: This invention relates to anti-FLT3 antibodies and methods of using them in enhancing immunity in a patient in need thereof and in treating cancer.
Abstract: This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-1 activity, e.g., cancer.
Type:
Application
Filed:
May 19, 2021
Publication date:
September 16, 2021
Applicant:
SYMPHOGEN A/S
Inventors:
Gunther Galler, Monika Gad, Klaus Koefoed, Ivan D. Horak, Thomas Bouquin, Michael Kragh, Mikkel Pedersen
Abstract: This invention relates to anti-AXL antibodies and methods of using them in treating diseases and conditions related to AXL activity, e.g., cancer.
Type:
Application
Filed:
February 26, 2021
Publication date:
September 2, 2021
Applicant:
SYMPHOGEN A/S
Inventors:
Torben GJETTING, Trine LINDSTED, Anton WILLER, Anne WORSAAE, Maria Carlsen MELANDER, Janus Schou JAKOBSEN, Randi Westh HANSEN
Abstract: This invention relates to anti-CD40 antibodies and methods of using them in treating diseases and conditions related to CD40 activity, e.g., cancer.
Type:
Application
Filed:
January 8, 2021
Publication date:
July 15, 2021
Applicant:
SYMPHOGEN A/S
Inventors:
Anton WILLER, Trine LINDSTED, Klaus KOEFOED, Mikkel Wandahl PEDERSEN, Lise Camilla FRÖHLICH
Abstract: This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-1 activity, e.g., cancer.
Type:
Grant
Filed:
September 30, 2016
Date of Patent:
June 15, 2021
Assignee:
Symphogen A/S
Inventors:
Gunther Galler, Monika Gad, Klaus Koefoed, Ivan D. Horak, Thomas Bouquin, Michael Kragh, Mikkel Pedersen
Abstract: This invention relates to anti-CD73 antibodies and methods of using them in treating diseases and conditions related to CD73 activity, e.g., cancer.
Type:
Application
Filed:
September 4, 2020
Publication date:
March 11, 2021
Applicant:
SYMPHOGEN A/S
Inventors:
Michael Monrad GRANDAL, Torben GJETTING, Johan LANTTO, Janus Schou JAKOBSEN, Randi Westh HANSEN, Camilla FRÖHLICH
Abstract: This disclosure relates to combination therapies targeting two or all of PD-1, TIM-3, and LAG-3 using antibodies specific for these targets in patients who are in need of enhanced immunity. Also included in the disclosure are compositions useful in the therapies. The therapies are useful in treating diseases such as cancers.
Type:
Application
Filed:
April 5, 2018
Publication date:
December 31, 2020
Applicant:
SYMPHOGEN A/S
Inventors:
Trine Lindsted, Michael Monrad Grandal, Eva Maria Carlsen Melander, Camilla Fröhlich, Mikkel Wandahl Pedersen, Michael Kragh, Johan Lantto, Monika Gad, Ivan David Horak
Abstract: The present invention provides methods and uses of anti-EGFR antibody compositions for treatment of cancers that are negative for certain mutations in RAS, BRAF, and the EGFR extracellular domain and are resistant to other anti-EGFR therapies.
Type:
Application
Filed:
August 29, 2018
Publication date:
November 5, 2020
Applicant:
SYMPHOGEN A/S
Inventors:
Michael Kragh, Thomas Tuxen POULSEN, Cliff DING, Ivan David Horak
Abstract: This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-lactivity, e.g., cancer.
Type:
Application
Filed:
November 17, 2017
Publication date:
December 5, 2019
Applicant:
SYMPHOGEN A/S
Inventors:
Johan LANTTO, Thomas BOUQUIN, Klaus KOEFOED, Torben GJETTING, Vikram Kjoller BHATIA, Monika GAD, Gunther Roland GALLER, Camilla FROHLICH
Abstract: The present invention relates to novel recombinant antibodies directed against human MET (c-MET), as well as compositions comprising mixtures of at least two of said antibodies and use of the antibodies and antibody compositions for treatment of MET-mediated disorders such as cancer.
Type:
Grant
Filed:
September 15, 2015
Date of Patent:
October 22, 2019
Assignee:
Symphogen A/S
Inventors:
Thomas Bouquin, Mikkel Wandahl Pedersen, Helle Jane Jacobsen, Thomas Tuxen Poulsen, Michael Monrad Grandal, Klaus Koefoed, Michael Kragh, Karsten Wessel Eriksen, Paolo Conrotto
Abstract: This invention relates to anti-TIM-3 antibodies and antibody compositions and their use in enhancing immunity in a patient, e.g., to treat cancer.
Type:
Application
Filed:
April 11, 2017
Publication date:
September 12, 2019
Applicant:
SYMPHOGEN A/S
Inventors:
Trine LINDSTED, Torben GJETTING, Gunther Roland GALLER, Monika GAD, Michael Monrad GRANDAL, Klaus KOEFOED, Michael KRAGH, Ivan David HORAK, Thomas BOUQUIN, Mikkel Wandahl PEDERSEN
Abstract: This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-1 activity, e.g., cancer.
Type:
Application
Filed:
September 30, 2016
Publication date:
May 16, 2019
Applicant:
SYMPHOGEN A/S
Inventors:
Gunther Galler, Monika Gad, Klaus Koefoed, Ivan D. Horak, Thomas Bouquin, Michael Kragh, Mikkel Pedersen