Abstract: The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated A? starting with pyroglutamate (A??E), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing A? oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056.
Type:
Grant
Filed:
June 3, 2011
Date of Patent:
August 5, 2014
Assignees:
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin, Synaptic Systems Gesellschaft für Neurobiologische Forschung, Entwicklung und Produktion mbH
Inventors:
Thomas Bayer, Oliver Wirths, Henrik Martens, Christian Erck