Abstract: The acetylcholinesterase 14-mer peptide AEFHRWSSYMVHWK acts alone or in synergism with 2-amyloid to contribute to neuronal degeneration, e.g. in Parkinson's and Alzheimer's diseases, perhaps by exerting calcium channel opening activity. Antibodies and other compounds which inhibit the biological activity are useful for prophylaxis or treatment.
Type:
Grant
Filed:
March 21, 1997
Date of Patent:
March 28, 2006
Assignee:
Synaptica Limited
Inventors:
Susan Adele Greenfield, David John Talbutt Vaux
Abstract: The acetylcholinesterase 14-mer peptide AEFHRWSSYMVHWK acts alone or in synergism with 2-amyloid to contribute to neuronal degeneration, e.g. in Parkinson's and Alzheimer's diseases, perhaps by exerting calcium channel opening activity. Antibodies and other compounds which inhibit the biological activity are useful for prophylaxis or treatment.
Type:
Application
Filed:
October 23, 1998
Publication date:
May 9, 2002
Applicant:
SYNAPTICA LIMITED
Inventors:
SUSAN ADELE GREENFIELD, DAVID JOHN TALBUTT VAUX
© 2024 Justia
