Abstract: A statistical framework for identifying regions of discrimination between two groups of imaged objects involves determining a weight map defining the regions of discrimination by minimizing the sample size required to discriminate the two groups in a numerical optimization scheme.

Abstract: A method for computer based analysis of a low field MR image including a trabecular region of bone for extracting from said image diagnostic information by applying a trained statistical classifier which has been trained on similar labelled according to the severity of a trabecular bone altering disease suffered at the time or later. For each image in the training set a region of interest (ROI) is defined, textural information relating to the intensities of voxels within the ROI is obtained, and combinations of features of said textural information are found which suitably classify the images according to said labelling. An image under study is treated similarly and features of said textural information for the voxels within the ROI of the image are combined as learnt in the training of the classifier to estimate a level of said trabecular bone altering disease or propensity to develop said bone altering disease or a level thereof associated with said image.

Abstract: Mammogram images are processed by computer to derive automatically a value for a parameter useful in detecting differences in breast tissue in subsequent images of the same breast or relative to a control group of such images, said derived parameter being a parameter that changes alongside changes in breast density and is hence useful in assessing cancer risk. The method comprises the steps of processing each image of at least part of a breast by: computing for pixels of the image a quotient value representative of the aspect ratio of tissue structures depicted in the image; using a trained classifier to classify said pixels according to their respective said quotient values and assigning a score to the respective pixels representing their classification with respect to at least two classes; deriving said parameter that changes alongside changes in breast density based on the aggregate pixel membership scores of said classes.

Abstract: A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure representative of cartilage homogeneity is derived from this three dimensional image data. The measured value is compared with similar measured values previously established in respect of healthy joints and/or joints characterised by a pathology.

Abstract: A method of processing a mammogram image to derive a value for a parameter useful in detecting differences in breast tissue in subsequent images of the same breast or relative to a control group of such images, said derived parameter being an aggregate probability score reflecting the probability of the image being a member of a predefined class of mammogram images, comprises computing for each of a multitude of pixels within a large region of interest within the image a pixel probability score assigned by a trained statistical classifier according to the probability of said pixel belonging to an image belonging to said class, said pixel probability being calculated on the basis of a selected plurality of features of said pixels, and computing said parameter by aggregating the pixel probability scores over said region of interest. Saud features may include the 3-jet of said pixels.

Abstract: A method of manipulation of a representation of a 2-D shape for improving a General Procrustes Alignment process, comprising taking a starting 2-D shape defined by a set of landmarks derived from data representing a 2-D projection image of a body part such as a vertebra, in a suitably programmed computing device deriving for each landmark of the 2-D shape a probable relative depth by the application thereto of a statistical model based on a multiplicity of 3-D shapes defined by landmarks derived from 3-D images of similar said body parts, said landmarks having one depth and two spatial coordinates, said model relating the probable relative depth of each landmark in a 3-D-shape of a said body part to the spatial coordinates of the set of landmarks constituting a said shape, and based on the inferred relative depth of the landmarks of the starting 2-D shape deforming the starting 2-D shape to correct for apparent distortion caused by rotation about an axis parallel to the projection plane of the imaged body par

Abstract: A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure of local curvature of the cartilage is determined within a region of interest. The value of the quantitative parameter of this joint derived from this measure is compared with the value of a similar quantitative parameter previously established in respect of healthy joints and/or joints characterized by a pathology.

Abstract: A method of processing a mammogram image to derive a value for a parameter useful in detecting differences in breast tissue in subsequent images of the same breast or relative to a control group of such images, said derived parameter being an aggregate probability score reflecting the probability of the image being a member of a predefined class of mammogram images, comprises computing for each of a multitude of pixels within a large region of interest within the image a pixel probability score assigned by a trained statistical classifier according to the probability of said pixel belonging to an image belonging to said class, said pixel probability being calculated on the basis of a selected plurality of features of said pixels, and computing said parameter by aggregating the pixel probability scores over said region of interest. Said features may include the 3-jet of said pixels.

Abstract: A method of deriving an estimate of the extent of fracture in a vertebra shown in an image of part of A spine is provided. The images of at least two vertebrae are segmented to obtain data representative of the shape and size of each of the vertebrae. An approximation of the shape of a first of the vertebrae is reconstructed by comparing the data obtained for a second of the two vertebrae with a mathematical model of at least the same two vertebrae of an unfractured spine. The unfractured shape of the first vertebra is predicted to enable a comparison of the shape and size of the first vertebra as imaged with the predicted unfractured shape and size. The difference between the respective images is subsequently computed to obtain a result representative of the extent of fracture in the first vertebra.

Abstract: A method for performing quality control on medical images in a clinical trial setting. In one embodiment, the method includes the steps of designating an image as reference image; obtaining attribute data from the reference image as reference attribute data; storing the reference image and the reference attribute data; subsequently taking a second image; obtaining attribute data from the second image as second attribute data; comparing the second image with the reference image on a single output screen; and denoting on the single output screen the second attribute data associated with the second image which differs from the reference data associated with the reference image.

Abstract: A frame for positioning and labeling an appendage relative to an x-ray cassette during x-radiography. In one embodiment, the frame includes an x-ray transparent plate having a first surface and a second surface; and a protrusion positioned on the first surface. The protrusion aids in the positioning of the appendage and preventing the first surface of the plate from being in contact with the x-ray cassette. In still yet another embodiment, the plate includes indicia for positioning the appendage. Another aspect of the invention is a method for positioning an appendage on x-ray cassette including the steps of: providing a frame having an x-ray transparent plate having a first surface and a second surface; and a protrusion positioned on the first surface; placing the plate on the x-ray cassette such that the second surface is in contact with the x-ray cassette; and placing the appendage on the plate.

Abstract: The invention relates to a frame for positioning a hand for medical imaging. In one embodiment, the frame includes a plate having a first surface and a second surface, and at least one indicium of handedness on one of the first and second surface. In the embodiment, at least one indicium of the frame is positioned asymmetrically on one of the first and second surfaces. In another embodiment, while, at least one of the first and second surfaces is flat, the other surface is shaped to raise the fingers of the hand, and has a raised platform to support the wrist of said hand. The indicium is visible under medical imaging illumination. Medical imaging is selected from a group consisting of: X-Ray, MRI (magnetic resonance imaging), computed tomography (CT), and PET (position emission tomography).

Abstract: A frame for determining the position and orientation of an x-ray source relative to an x-ray cassette during x-radiography. In one embodiment the frame includes an x-ray transparent or translucent plate having a first surface and a second surface; and a partially radio-opaque protrusion positioned on the first surface of the plate. In another embodiment, a method for determining the position and orientation of an x-ray source relative to an x-ray cassette is disclosed. The method includes the steps of providing a frame, including an x-ray transparent plate having a first surface and a second surface; and a protrusion having a radio-opaque portion positioned on the first surface of the plate, and placing the plate on the x-ray cassette such that the second surface is in contact with the x-ray cassette. The method further includes placing the appendage on the plate in close juxtaposition to the protrusion, exposing the appendage and plate to an x-ray beam, and examining the image formed.

Abstract: A method for providing a medical service in a therapeutic area requested by a client. In one embodiment, the method includes the step of defining a plurality of offerings associated with the medical service in the therapeutic area. At least one service category is associated with each of the offerings. At least one activity is associated with each of the service categories. At least one tool is associated with each of the activities. The method further includes the step of associating the offerings, the activities, the service categories and the tools with a respective plane of a hypercube. In response to the medical service, at least one location in the hypercube, which represents the offering, service category, activity and tool required to provide the medical service, is identified.

Abstract: The invention provides a test device or “phantom” for use in conjunction with medical imaging modalities. In one embodiment, the phantom replicates the attenuation and absorption properties of joint articular cartilage. The phantom is useful for quality assurance of images of joints obtained using an array of medical imaging modalities.

Abstract: The invention provides a test device or “phantom” for use in conjunction with medical imaging modalities. The phantom mimics the properties of joint particular cartilage. The phantom is useful for quality assurance of images of joints obtained using an array of medical imaging modalities.

Abstract: The invention provides a test device or “phantom” for use in conjunction with medical imaging modalities. In one embodiment, the phantom replicates the attenuation and absorption properties of joint articular cartilage. The phantom is useful for quality assurance of images of joints obtained using an array of medical imaging modalities.

Abstract: The invention provides a test device or “phantom” for use in conjunction with medical imaging modalities. The phantom mimics the properties of joint particular cartilage. The phantom is useful for quality assurance of images of joints obtained using an array of medical imaging modalities.