Patents Assigned to Synbias Pharma AG
  • Bendamustine derivatives and related compounds, and medical use thereof in cancer therapy
    Patent number: 10526290
    Abstract: The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: January 7, 2020
    Assignee: SYNBIAS PHARMA AG
    Inventors: Helmut Schickaneder, Christian Schickaneder, Armin Buschauer, Stefan Huber, Michael Limmert, Günther Bernhardt, Mathias Lubbe, Harald Hofmeier
  • Method for the synthesis of rapamycin derivatives
    Patent number: 10308665
    Abstract: The present invention relates to a method for the production of a rapamycin derivative of formula (I), the method comprising the preparation of a 2-(tri-substituted silyl)oxyethyl triflate by reacting ethylene oxide and a tri-substituted silyl triflate, reaction of the resulting 2-(tri-substituted silyl)oxyethyl triflate with rapamycin in the presence of a molar excess of organic base, and deprotection to obtain the rapamycin derivative of compound (I).
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 4, 2019
    Assignee: Synbias Pharma AG
    Inventors: Oleksandr Zabudkin, Christian Schickaneder, Iaroslav Matviienko, Volodymyr Sypchenko
  • Bendamustine derivatives and related compounds, and medical use thereof in cancer therapy
    Patent number: 10294208
    Abstract: The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: May 21, 2019
    Assignee: SYNBIAS PHARMA AG
    Inventor: Helmut Schickaneder
  • VINORELBINE MONOTARTRATE AND ITS PHARMACEUTICAL USE
    Publication number: 20190092792
    Abstract: The present invention is directed to crystalline vinorelbine monotartrate and its use for the prevention and treatment of cancer, particularly non-small cell lung cancer or breast cancer. The present invention also relates to a corresponding method for the manufacture of crystalline vinorelbine monotartrate.
    Type: Application
    Filed: March 9, 2016
    Publication date: March 28, 2019
    Applicant: SYNBIAS PHARMA AG
    Inventors: Oleksandr Zabudkin, Viktor Matviyenko, Vladimir Matha, Christian Schickaneder, Iaroslav Matviienko, Volodymyr Sypchenko
  • Method for the synthesis of clofarabine
    Patent number: 10030043
    Abstract: The present invention relates to a method for the high yield production of the anticancer nucleoside clofarabine, the method comprising the preparation of 2-chloroadenosine by enzymatic transglycosylation between 2-chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: July 24, 2018
    Assignee: Synbias Pharma AG
    Inventors: Alexander Zabudkin, Victor Matvienko, Iaroslav Matviienko, Volodymyr Sypchenko
  • Method for the synthesis of irinotecan
    Patent number: 9765083
    Abstract: The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan), comprising: (a) preparing 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptotecin; and (b) selectively ethylating the compound of step (a) at the 7-position, thus resulting in the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. The present invention is further directed to the use of 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. 7-des-ethyl-irinotecan) as intermediate in a method for the synthesis of irinotecan as described.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: September 19, 2017
    Assignee: Synbias Pharma AG
    Inventors: Alexander Zabudkin, Viktor Matvienko
  • Method of producing 4-demethoxydaunorubicin
    Patent number: 8846882
    Abstract: The present invention relates to a method for the synthesis of 4-demethoxydaunorubicin (idarubicin) having the chemical structure of formula (I), which involves the demethylation of 3?-Prot-daunorubicin in the presence of a soft Lewis acid. The method of the present invention does not comprise cleavage of the glycosidic linkage at carbon C7, thus resulting in a faster synthesis cycle and an improved yield of the final product.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 30, 2014
    Assignee: Synbias Pharma AG
    Inventors: Alexander Zabudkin, Victor Matvienko, Alexey Matvyeyev