Abstract: A system and method for testing a subject for cognitive or oculomotor impairment includes presenting the subject with a display of an object, while presenting the display to the subject, and the subject's head moves horizontally or vertically within a predefined range of movement rates, measuring the subject's right eye positions and/or the subject's left eye positions. The system generates a metric by statistical analysis of the measurements of subject's right eye positions or the subject's left eye positions, and generates a report based on the metric. In some embodiments, the system is configured to train the subject to improve their performance, and thereby remediate or reduce cognitive and oculomotor impairment.

Abstract: A method of presenting content to a subject based on eye position measurements includes presenting the subject with content. While presenting the content to the subject, one or more of the subject's eye positions is measured, from which a locus of the subject's gaze is determined. The method includes continuously performing the operations of: generating an attention metric using the one or more measured eye positions; based on the attention metric, determining an attention state of the subject; and determining a trajectory of the locus of the subject's gaze. In accordance with detecting a change in the attention state of the subject, the presentation of the content is modified based on the trajectory of the locus of the subject's gaze so as to present different content than if the attention state of the subject had remained the not attending state.

Abstract: A method of presenting content to a subject based on eye position measurements includes presenting the subject with content. While presenting the content to the subject, one or more of the subject's eye positions is measured. The method includes continuously performing the operations of: generating an attention metric using the one or more measured eye positions; based on the attention metric, determining an attention state of the subject; and determining a trajectory of the one or more eye positions. In accordance with detecting a change in the attention state of the subject, the presentation of the content is modified based on the trajectory of the one or more eye positions so as to present different content than if the attention state of the subject had remained the not attending state.

Abstract: A method of presenting content to a subject based on eye position measurements is provided. The method includes presenting the subject with content. While presenting the content to the subject, one or more of the subject's eye positions is measured. The method further includes continuously performing the operations of generating a variability metric using the one or more measured eye positions and comparing the variability metric with a predetermined baseline to determine an attention state of the subject. Upon detection of a change in the attention state, the presentation of the content is modified.

Abstract: A method of visual cognitive training is performed at a device with a display. The method includes sequentially displaying a plurality of visual stimuli in a first region of a subject's field of view. While sequentially displaying the plurality of visual stimuli, the device moves the first region periodically along a predefined path within the subject's field of view. The device prompts the subject to respond to a task associated with the sequential display of the plurality of visual stimuli. The device receives a response to the task associated with the sequential display of the plurality of visual stimuli and records information corresponding to the subject's response to the task associated with the sequential display of the plurality of visual stimuli.

Abstract: A universal headset-mounted Neuropsychological Testing System utilizes eye tracking, with a single screen fixed with respect to the face and a dot on the screen driven to present an object that both eyes are focused on using a set of prisms, with the prisms eliminating interocular distance considerations. Ultrathin optics cast a virtual image at 40 centimeters and a universal mask against which the test taker's face is placed fixes the single screen with respect to the face so that head movement is not a factor. Additionally, miniature cameras are located in the headset housing beneath the eyes, and a quick release tensioning unit provides easy headset mounting and removal. Moreover, all elements are located in the headset hood to eliminate the effects of head movement as well as environmental distractions.

Abstract: A method is provided for improving cognitive performance assessment in a smooth pursuit cognitive performance test by using measurement metrics including a lead/lag metric, a radial inbounding metric, a path dependent velocity metric, a path drift metric, a velocity variability metric, or a variance statistics metric.

Abstract: The invention describes the process of applying smooth pursuit eye movement tests toward the detection of the efficacy and, or, toxicity of neuro-pharmaceutical compounds throughout the clinical drug development process. Several different paradigms in smooth pursuit tracking tests and several analysis methods and metrics may be used. Application of smooth pursuit tracking tests allows for a quantifiable measurement of a subject's cognitive behavior and function. This process provides a cost effective and objective test of efficacy of neuro-pharmaceutical drugs and increase the validity of the clinical drug development process.

Abstract: A universal headset-mounted Neuropsychological Testing System utilizes eye tracking, with a single screen fixed with respect to the face and a dot on the screen driven to present an object that both eyes are focused on using a set of prisms, with the prisms eliminating interocular distance considerations. Ultrathin optics cast a virtual image at 40 centimeters and a universal mask against which the test taker's face is placed fixes the single screen with respect to the face so that head movement is not a factor. Additionally, miniature cameras are located in the headset housing beneath the eyes, and a quick release tensioning unit provides easy headset mounting and removal. Moreover, all elements are located in the headset hood to eliminate the effects of head movement as well as environmental distractions.

Abstract: A highly portable desktop arrangement for cognitive testing which eliminates environmental effects is provided by a clam shell enclosure having a face mask on one face and housing a computer screen at an opposing wall, with accurate gaze direction measurement made by determining the position of the pupil if an individual whose face is pressed to the mask for eliminating head movement relative to the computer screen.

Abstract: Gesture sensing is used as an input to perform cognitive function testing.

Abstract: A system for monitoring drug taking compliance utilizes cognitive testing after the scheduled administration of the medicine to determine compliance by measuring cognitive function.

Abstract: A system for removing the learning effects from cognitive tests includes variation of the difficulty of the test between the administering of the tests so as to minimize the ability of a test taker to memorize a test.

Abstract: A method is provided for improving cognitive performance assessment in a smooth pursuit cognitive performance test by using measurement metrics including a lead/lag metric, a radial inbounding metric, a path dependent velocity metric, a path drift metric, a velocity variability metric, or a variance statistics metric.

Abstract: Multimodal cognitive performance testing identifies a benchmark test administered at the beginning and the end of a battery of tests in which cognitive resource changes are detected and are used to correct additional tests sandwiched between the benchmark tests. A test sequence methodology is described for deriving a minimum number of the additional tests and for ordering the additional tests based on multimodal test variables and correlation of a test with a predetermined cognitive function.

Abstract: A method to determine the subject's peak cognitive performance using smooth pursuit tracking tests. The method utilizes instantaneous performance feedback to accurately quantify the subject's peak cognitive performance by changing the difficulty of the test in response to the subject's performance.

Abstract: The invention describes the process of applying smooth pursuit eye movement tests toward the detection of the efficacy and, or, toxicity of neuro-pharmaceutical compounds throughout the clinical drug development process. Several different paradigms in smooth pursuit tracking tests and several analysis methods and metrics may be used. Application of smooth pursuit tracking tests allows for a quantifiable measurement of a subject's cognitive behavior and function. This process provides a cost effective and objective test of efficacy of neuro-pharmaceutical drugs and increase the validity of the clinical drug development process.