Patents Assigned to Synectics, Inc.
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Patent number: 10058510Abstract: Disclosed herein a pharmaceutical composition comprising aprepitant a pharmaceutically acceptable salt thereof; at least one hydrocarbon derivative selected from among a fatty acid of 14 to 18 carbon atoms, and a fatty alcohol of 14 to 18 carbon atoms; and at least one selected from among polyoxyethyelene-type nonionic surfactant, sucrose fatty acid ester, and Macrogol 15 hydroxystearate. The pharmaceutical composition of the present disclosure can release aprepitant or a pharmaceutically acceptable salt thereof to effectively exert the pharmaceutical efficacy, and can be dissolved in a fasted state simulated gastrointestinal fluid so that it can be useful for study on the in vivo pharmacokinetic behavior of aprepitant.Type: GrantFiled: January 14, 2016Date of Patent: August 28, 2018Assignees: Daewoong Pharmaceutical Co., Ltd., Bio-Synectics Inc.Inventors: Sanghee Kim, Hee Chul Chang, Ji Hoon Jung
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Publication number: 20180000741Abstract: Disclosed herein a pharmaceutical composition comprising aprepitant a pharmaceutically acceptable salt thereof; at least one hydrocarbon derivative selected from among a fatty acid of 14 to 18 carbon atoms, and a fatty alcohol of 14 to 18 carbon atoms; and at least one selected from among polyoxyethyelene-type nonionic surfactant, sucrose fatty acid ester, and Macrogol 15 hydroxystearate. The pharmaceutical composition of the present disclosure can release aprepitant or a pharmaceutically acceptable salt thereof to effectively exert the pharmaceutical efficacy, and can be dissolved in a fasted state simulated gastrointestinal fluid so that it can be useful for study on the in vivo pharmacokinetic behavior of aprepitant.Type: ApplicationFiled: January 14, 2016Publication date: January 4, 2018Applicants: Daewoong Pharmaceutical Co., Ltd., Bio-Synectics Inc.Inventors: Sanghee KIM, Hee Chul CHANG, Ji Hoon JUNG
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Patent number: 9439871Abstract: The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point or glass transition temperature of 80° C. or lower and an active material, and mills the mixture using a roller mill, to thereby prepare nanoparticle powder from the active material.Type: GrantFiled: September 21, 2012Date of Patent: September 13, 2016Assignee: BIO-SYNECTICS, INC.Inventors: Kab Sig Kim, Joo Won Park
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Patent number: 9393201Abstract: The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by 5 emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas.Type: GrantFiled: September 20, 2010Date of Patent: July 19, 2016Assignees: JW Pharmaceutical Corporation, Bio-Synectics, Inc.Inventors: Sung Jae Lee, Young Hoon Kim, Sang Heon Lee, Kab Sig Kim
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Publication number: 20150031707Abstract: The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point or glass transition temperature of 80° C. or lower and an active material, and mills the mixture using a roller mill, to thereby prepare nanoparticle powder from the active material.Type: ApplicationFiled: September 21, 2012Publication date: January 29, 2015Applicant: BIO-SYNECTICS INC.Inventors: Kab Sig Kim, Joo Won Park
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Patent number: 8828445Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.Type: GrantFiled: March 22, 2011Date of Patent: September 9, 2014Assignee: Bio-Synectics Inc.Inventors: Kab Sig Kim, Joo Won Park
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Publication number: 20120177728Abstract: The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas. By providing oxaliplatin, which is currently available only in injection form for parenteral administration, in the form of a nanoparticle, the present invention allows for the development of orally administrable oxaliplatin which is stable against gastric acid and has improved bioavailability, thereby improving patient compliance through avoiding the inconvenience of injection and greatly reducing medical cost.Type: ApplicationFiled: September 20, 2010Publication date: July 12, 2012Applicants: Bio-Synectics, Inc., JW Pharmaceutical CorporationInventors: Sung Jae Lee, Young Hoon Kim, Sang Heon Lee, Kab Sig Kim
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Patent number: 8211470Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.Type: GrantFiled: November 11, 2004Date of Patent: July 3, 2012Assignee: Bio-Synectics Inc.Inventor: Kab-Sig Kim
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Publication number: 20070071826Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.Type: ApplicationFiled: November 11, 2004Publication date: March 29, 2007Applicant: BIO-SYNECTICS INC.Inventor: Kab-Sig Kim
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Patent number: 4873563Abstract: A monolithic switching array integrated with control logic on a dielectrically isolated monolithic substrate is provided wherein individual components are constructed in abutment with the oxide walls of the dielectrically isolated wells to form a diffusion/wall interface. As a consequence, area of the wells can be optimally used, and undesired electric fields around the components are minimized, thus allowing for smaller overall chip dimensions as compared with comparable prior art dielectric isolation (d.i.) or junction isolated construction techniques. Moreover, d.i. construction eliminates undesired parasitic devices in a monolithic circuit and allows for improved system accuracy.Type: GrantFiled: May 2, 1988Date of Patent: October 10, 1989Assignee: Synectics, Inc.Inventors: Stephen L. Daleo, James B. Compton
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Patent number: 4491624Abstract: An electrochemical cell for which fuel is prepared and introduced under artificial gravity forces. The active metal is deposited through the action of the field on an anode current collecting member, effecting good compaction and reduced cell internal impedance. A microprocessor provides control of the induced gravity, flow rates, temperature, and other variables-enabling the active metal to be controlled in its thickness as well as providing a predetermined separation from the cathode. Abrasion of the cathode and the possibility of shorting are avoided by the presence of outwardly directed radial forces. These forces are induced by rotation of the electrolyte, air cathode, anode collector and the active metal. The forces promote also the passage of moisture laden air through the air cathode elements. Reaction products produced within the cell volume are circulated to an outside container for separation and possible reuse.Type: GrantFiled: September 30, 1982Date of Patent: January 1, 1985Assignee: Synectics, Inc.Inventors: Robert I. Sarbacher, Harry R. Fechter