Abstract: A novel method for the labeling of oligonucleotides which results in the economical synthesis of 5? labeled molecules. A set of suitably protected and carefully selected set of amino linkers, a modified deprotination/cleavage protocol and standard coupling methodologies to are used to allow for the convergent synthesis of any number of labeled oligonucleotides.
Type:
Grant
Filed:
June 28, 2001
Date of Patent:
February 27, 2007
Assignee:
Syn Gen, Inc.
Inventors:
Ronald H. Chiarello, Wing-Cheong Liu, Gabriel G. Alvarado