Patents Assigned to Syngenix Limited
  • Compositions comprising a tissue glue and therapeutic agents
    Patent number: 6919067
    Abstract: The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present invention are particularly useful for providing local radiotherapy. The present invention also concerns methods of using the compositions of the invention, particularly for radiotherapy.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: July 19, 2005
    Assignee: Syngenix Limited
    Inventors: Aaron Gershon Filler, Andrew Michael Lindsay Lever
  • Particulate agents
    Publication number: 20030228260
    Abstract: A novel means of pharmaceutical delivery for therapy of prophylaxis or to assist surgical or diagnostic operations on the living body is provided by neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g., intramuscular injections of a nerve adhesion molecule in coupled particle comprising a physiologically active substance or a diagnostic marker.
    Type: Application
    Filed: January 16, 2003
    Publication date: December 11, 2003
    Applicant: Syngenix Limited
    Inventor: Aaron Gershon Filler
  • Particular agents
    Patent number: 6562318
    Abstract: A novel means of pharmaceutical delivery for therapy or prophylaxis or to assist surgical or diagnostic operations on the living body is provided by agents which undergo neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g., intramuscular injections of a nerve adhesion molecule comprising a physiologically active substance or a diagnostic marker.
    Type: Grant
    Filed: July 26, 1999
    Date of Patent: May 13, 2003
    Assignee: Syngenix Limited
    Inventor: Aaron Gershon Filler
  • Synthetic transfection vectors
    Patent number: 6153598
    Abstract: An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for achieving efficient transfection of associated nucleic acid into a cell.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: November 28, 2000
    Assignee: Syngenix Limited
    Inventors: Aaron Gershon Filler, Andrew Michael Lindsay Lever
  • Particulate agents
    Patent number: 5948384
    Abstract: A novel means of pharmaceutical delivery for therapy of prophylaxis or to assist surgical or diagnostic operations on the living body is provided by neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g. intramuscular injections of a nerve adhesion molecule in coupled particle comprising a physiologically active substance or a diagnostic marker.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 7, 1999
    Assignee: Syngenix Limited
    Inventor: Aaron Gershon Filler
  • Mason-Pfizer Monkey Retroviral packaging defective vectors
    Patent number: 5747307
    Abstract: Novel vectors are capable of producing MPMV (Mason-Pfizer Monkey Virus) proteins but not of packaging MPMV RNA, and the information about the packaging signal in MPMV and HIV can be used to create MPMV and HIV vectors that are capable of transferring foreign genes, e.g. for use in gene therapy.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: May 5, 1998
    Assignee: Syngenix Limited
    Inventors: Andrew Michael Lindsay Lever, Eric Hunter
  • Particulates
    Patent number: 5614652
    Abstract: There is provided a means of cellular level therapy or prophylaxis whereby endocytosable particles are administered so as to emit cytotoxic radiation or to release metal cations having a therapeutic or prophylactic effect, eg. a vital replication suppressing effect, within cells such as macrophages following their uptake by these cells.
    Type: Grant
    Filed: October 5, 1993
    Date of Patent: March 25, 1997
    Assignee: Syngenix Limited
    Inventors: Aaron G. Filler, Andrew M. Lever
  • Nucleic acid amplification using scandium and lanthanum ions
    Patent number: 5554498
    Abstract: The subject invention pertains to a method for amplifying the polymerase activity of a nucleic acid polymerase using Group 3 ions. Group 3 ions of the subject invention can also be used to inhibit the enzymatic activity of nucleases. The subject invention further concerns a method for identifying an unknown nucleic acid polymerase or other enzymes in a sample.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: September 10, 1996
    Assignee: Syngenix Limited
    Inventors: Aaron G. Filler, Andrew M. L. Lever