Abstract: The present invention relates to methods and compositions for modifying a target site in the genome of a plant cell. Such modifications include integration of a transgene and mutations. The present invention also relates to methods and compositions for identifying and enriching for cells which comprise a modified target site.
Type:
Application
Filed:
February 17, 2021
Publication date:
July 15, 2021
Applicant:
SYNGENTA PARTICIPATIONS AG
Inventors:
Zhongying Chen, Myoung Kim, Mary-Dell Chilton, Heng Zhong, Weining Gu, Yaping Jiang, Qiudeng Que
Abstract: Novel insecticidal proteins isolated from Bacillus thuringiensis that are active against lepidopteran insect pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform various prokaryotic and eukaryotic organisms to express the insecticidal proteins. These recombinant organisms can be used to control lepidopteran insects in various environments.
Type:
Grant
Filed:
November 14, 2019
Date of Patent:
July 13, 2021
Assignee:
Syngenta Participations AG
Inventors:
Matthew Richard Bramlett, Katherine Seguin, Vance Cary Kramer, Mark Scott Rose
Abstract: The invention relates to crystalline forms of N-[2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)pyridine-3-carboxamide of formula (I), compositions comprising said crystalline forms and methods of their use as nematicides or fungicides.
Abstract: Soybean plants comprising event SYHT0H2, methods of detecting and using the same, and soybean plants comprising a heterologous insert at the same site as SYHT0H2.
Type:
Grant
Filed:
October 25, 2018
Date of Patent:
July 6, 2021
Assignee:
Syngenta Participations AG
Inventors:
John Daniel Hipskind, Kristina Burgin, Rakesh Jain, Karolyn Terpstra, Marina Sigareva, Annick Jeanne De Framond, Becky Breitinger, Vance Cary Kramer, Weining Gu
Abstract: The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides by reacting (a) cyclopropylcarbonitrile to a cyclopropylcarbaldehyde, (b) further reacting to a cyclobutanone, or (d?) further reacting to an enamide, (c) further reacting to enantiomerically and diastereomerically enriched cyclobutane amines, or (d) further reacting to an enamide and (e) to an enantiomerically and diastereomerically enriched cyclobutylamide to obtain (f) an enantiomerically and diastereomerically enriched cyclobutane amine, and (g) further reacting to an enantiomerically and diastereomerically enriched cyclobutane amide.
Type:
Grant
Filed:
November 14, 2018
Date of Patent:
July 6, 2021
Assignee:
SYNGENTA PARTICIPATIONS AG
Inventors:
Raphael Dumeunier, Tomas Smejkal, Brijnandan Premnath Mishra, Vijayagopal Raman Gopalsamuthiram, Edouard Godineau, Anthony Cornelius O'Sullivan
Abstract: The invention relates generally to peptide biomarkers with specific ionization characteristics to directly quantify one or more transgenic target proteins in biological samples, including transgenic plant samples, by liquid chromatography coupled tandem mass spectrometry multiple reaction monitoring (MRM). The peptide biomarkers in combination with MRM-based methods may be used to quantify a single transgenic target protein or multiple transgenic target proteins within a stacked transgenic crop, such as maize, utilizing selected peptide biomarkers either alone or in combination. The present disclosure allows for broad based, reliable quantitation in different biological matrices, including plant matrices. The peptide biomarkers of the invention can further be used as trait biomarkers to support identification and/or selection of specific transgenic Events. Also provided are different peptide biomarker combinations that can be used to perform the methods of the invention.
Type:
Application
Filed:
August 14, 2019
Publication date:
June 24, 2021
Applicant:
Syngenta Participations AG
Inventors:
Scott Young, Richard Sessler, Gerson Graser, Rudolf Guilbaud, Michael Schirm, Maxim Isabelle
Abstract: The present invention relates to methods and compositions for targeted insertion of polynucleotide molecules into ideal target sites in the genome of a maize plant. The present invention relates to maize recombinant molecules comprising heterologous sequences and also to methods of integrating a DNA of interest into a target maize genomic locus in a maize genome. The present invention also relates to regenerated maize plants or plant parts comprising the recombinant molecules and/or a DNA of interest.
Type:
Application
Filed:
December 12, 2018
Publication date:
June 24, 2021
Applicant:
SYNGENTA PARTICIPATIONS AG
Inventors:
Yinping Lucy Qin, Mark Rose, Zhongying Chen, Heng Zhong, Weining Gu, Wenling Wang, Qiudeng Que, Ailing Zhou, Mary-Dell Chilton
Abstract: Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed.
Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
Abstract: The present invention relates to new compounds of formula (I) for the promotion of seed germination, to processes for preparing the compounds, to seeds comprising the compounds, to seed germination promoting compositions comprising the compounds and to methods of using the compounds for promoting the germination of seeds. In particular, the compounds are useful in promoting germination of corn under cold stress conditions.
Type:
Grant
Filed:
February 1, 2018
Date of Patent:
June 22, 2021
Assignee:
SYNGENTA PARTICIPATIONS AG
Inventors:
Alain De Mesmaeker, Claudio Screpanti, Alexandre Franco Jean Camille Lumbroso
Abstract: The invention relates generally to synthetic non-antibody protein scaffolds (synNAPS) that differentially detect or quantitate a target insecticidal protein in a complex biological matrix comprising the target protein and a non-target insecticidal protein and to methods of using the synNAPS in immunoassays, and more particularly to monoclonal antibodies and immunoassays for the differential detection and quantitation of a wild-type crystal protein, such as a wild-type-Cry1Ab, from Bacillus thuringiensis and hybrid crystal proteins, which comprise all or a significant portion of the wild-type Cry protein in complex biological samples comprising both the wild-type Cry protein and one or more of the hybrid Cry proteins.
Type:
Application
Filed:
December 13, 2018
Publication date:
June 17, 2021
Applicant:
Syngenta Participations AG
Inventors:
Michele YARNELL, Anne CHEVREL, Olivier Kitten, Scott Young
Abstract: The present invention relates to a novel process for the synthesis of herbicidal pyrazolidinedione compounds. In particular, a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined herein. The present invention further relates to novel intermediate compounds utilized in said process, and methods for preparing said intermediate compounds.
Type:
Application
Filed:
December 4, 2018
Publication date:
June 10, 2021
Applicant:
Syngenta Participations AG
Inventors:
James Alan MORRIS, Alexandr SHAFIR, Mallikharjuna GONU, Iffat BILAL, David Alexander SALE
Abstract: The present invention is directed to the vegetative insecticidal proteins (Vips) modified to comprise heterologous bacterial carbohydrate binding modules and the methods of use thereof. Expression of modified proteins resulted in variations to activity against lepidopteran pest species of agricultural importance such as Corn earworm and Fall armyworm conveying broad spectrum insect control.
Abstract: Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also provided are expression cassettes; vectors; transgenic plant cells; plants, plant parts, and seeds; isolated polypeptides; amplicons and informative fragments of the presently disclosed nucleic acids; compositions that include amplification primer pairs; methods for producing plants that exhibit HI; methods for identifying the presence or absence of an allele associated with HI in a plant; methods for introgressing Haploid-inducing nucleotide sequences into plants; and methods for selecting parental plants predicted to produce progeny generations with plants that exhibit Haploid Induction trait.
Type:
Application
Filed:
February 12, 2021
Publication date:
June 3, 2021
Applicant:
Syngenta Participations AG
Inventors:
Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu KADARU, Todd Lee Warner, William Paul Bullock
Abstract: Artificially selected strains of insects from the genus Spodoptera exhibiting resistance to a Bacillus thuringiensis derived Vip3A protein are described. Methods for various uses of these strains are also described.
Type:
Application
Filed:
February 11, 2021
Publication date:
June 3, 2021
Applicant:
SYNGENTA PARTICIPATIONS AG
Inventors:
Julio Fatoretto, Zhimou Wen, Phillip Matthews, Jeng Shong Chen
Abstract: Novel insecticidal proteins that are toxic to lepidopteran pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms to express the insecticidal proteins. The recombinant organisms or compositions containing the recombinant organisms or the insecticidal proteins alone or in combination with an appropriate agricultural carrier can be used to control lepidopteran pests in various environments.
Type:
Application
Filed:
February 3, 2021
Publication date:
June 3, 2021
Applicant:
Syngenta Participations AG
Inventors:
Matthew Richard BRAMLETT, Katherine Seguin, Vance Cary Kramer, Mark Scott Rose
Abstract: The present invention relates to methods and compositions for identifying, selecting and/or producing a soybean plant or germplasm having resistance Phakosora pachyrhizi. A soybean plant, part thereof and/or germplasm that has been identified, selected and/or produced by any of the methods of the present invention is also provided. Also provided are single nucleotide polymorphisms (SNPs) associated with resistance to pathogens; and compositions including amplification primer pairs capable of initiating DNA polymerization by a DNA polymerase on soybean nucleic acid templates to generate soybean marker amplicons.
Type:
Grant
Filed:
May 7, 2019
Date of Patent:
June 1, 2021
Assignee:
Syngenta Participations AG
Inventors:
Anderson Rotter Meda, Becky Welsh Breitinger, Flavia Fernandes Carneiro, Andreomar Jose Kurek