Patents Assigned to Synlogic, Inc.
  • BACTERIA ENGINEERED TO TREAT DISORDERS IN WHICH OXALATE IS DETRIMENTAL
    Publication number: 20180325963
    Abstract: The present invention provides recombinant bacterial cells comprising at least one heterologous gene encoding at least one oxalate catabolism enzyme. In another aspect, the recombinant bacterial cells further comprise at least one heterologous gene encoding an importer of oxalate. The invention further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders in which oxalate is detrimental, such as hyperoxaluria, using the pharmaceutical compositions of the invention.
    Type: Application
    Filed: August 31, 2016
    Publication date: November 15, 2018
    Applicant: Synlogic, Inc.
    Inventors: Vincent Isabella, Dean Falb, Cami Leigh Anderson, Paul Miller, Yves Millet, Jonathan Kotula
  • Bacteria Engineered to Treat Diseases that Benefit from Reduced Gut Inflammation and/or Tighten Gut Mucosal Barrier
    Publication number: 20180273956
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
    Type: Application
    Filed: January 11, 2018
    Publication date: September 27, 2018
    Applicant: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller
  • Bacteria engineered to reduce hyperphenylalaninemia
    Patent number: 9943555
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: April 17, 2018
    Assignee: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Yves Millet, Sarah Rowe
  • Bacteria engineered to treat a disease or disorder
    Patent number: 9889164
    Abstract: Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: February 13, 2018
    Assignee: Synlogic, Inc.
    Inventors: Dean Falb, Paul F. Miller, Jonathan W. Kotula, Vincent M. Isabella, Suman Machinani, Adam B. Fisher, Yves Millet
  • PROBIOTIC ORGANISMS FOR DIAGNOSIS, MONITORING, AND TREATMENT OF INFLAMMATORY BOWEL DISEASE
    Publication number: 20170360850
    Abstract: Aspects of the present disclosure relate to genetically engineered organisms useful for the diagnosis and treatment of inflammatory bowel disease.
    Type: Application
    Filed: December 22, 2015
    Publication date: December 21, 2017
    Applicants: Massachusetts Institute of Technology, Synlogic, Inc.
    Inventors: Timothy Kuan-Ta Lu, Jacob Rosenblum Rubens, Isaak Elis Mueller, Gianluca Selvaggio, Paul Miller, Dean Falb, Vincent Isabella, Jonathan Kotula
  • Bacteria engineered to treat diseases associated with hyperammonemia
    Patent number: 9688967
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: June 27, 2017
    Assignee: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Suman Machinani
  • BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER
    Publication number: 20170067065
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
    Type: Application
    Filed: September 8, 2016
    Publication date: March 9, 2017
    Applicant: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Yves Millet, Adam Fisher
  • Bacteria engineered to treat diseases associated with hyperammonemia
    Patent number: 9487764
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: November 8, 2016
    Assignee: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller
  • Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
    Publication number: 20160206666
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
    Type: Application
    Filed: December 22, 2015
    Publication date: July 21, 2016
    Applicant: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller