Patents Assigned to Synmax Biochemical Co., Ltd.
  • Mutated penicillin expandase and process for preparing 7-ADCA using the same
    Patent number: 6905854
    Abstract: The present invention relates to a mutated expandase enzyme having higher activity on penicillin G and produces 7-aminodeacetoxycephalosporanic acid (7-ADCA). In certain embodiments, the mutated expandase enzyme has one or more amino acid substitutions selected from the group consisting of methionine 73, glycine 79, valine 275, leucine 277, cysteine 281, glycine 300, asparagine 304, isoleucine 305, threonine 91, alanine 106, cysteine 155, tyrosine 184, methionine 188 and histidine 244, provided that the amino acid substitution at the residue position of asparagine 304 is not N304L and the amino acid substitution at the residue position of cysteine 155 is C155Y.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: June 14, 2005
    Assignee: Synmax Biochemical Co., Ltd.
    Inventors: Yang Yunn-Bor, Wei Chia-Li, Hsu Jyh-Shing, Tsai Ying-Chieh
  • Mutated penicillin expandase and process for preparing 7-ADCA using the same
    Publication number: 20040259191
    Abstract: A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more amino acid substitutions selected form M73T, S79E, V275I, L277K, C281Y, G300V, N304K, I305L and I305M.
    Type: Application
    Filed: February 27, 2004
    Publication date: December 23, 2004
    Applicant: Synmax Biochemical Co., Ltd.
    Inventors: Yunn-Bor Yang, Chia-Li Wei, Jyh-Shing Hsu, Ying-Chieh Tsai
  • Mutated penicillin expandase and process for preparing 7-ADCA using the same
    Publication number: 20040121425
    Abstract: A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more amino acid substitutions selected form M73T, S79E, V275I, L277K, C281Y, G300V, N304K, I305L and I305M.
    Type: Application
    Filed: November 21, 2003
    Publication date: June 24, 2004
    Applicant: Synmax Biochemical Co., Ltd.
    Inventors: Yang Yunn-Bor, Wei Chia-Li, Hsu Jyh-Shing, Tsai Ying-Chieh
  • Mutated penicillin expandase and process for preparing 7-ADCA using the same
    Publication number: 20040077035
    Abstract: A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more amino acid substitutions selected form M73T, S79E, V2751, L277K, C281Y,
    Type: Application
    Filed: November 21, 2003
    Publication date: April 22, 2004
    Applicant: Synmax Biochemical Co., Ltd.
    Inventors: Yang Yunn-Bor, Wei Chia-Li, Hsu Jyh-Shing, Tsai Ying-Chieh
  • Mutated penicillin expandase and process for preparing 7-ADCA using the same
    Publication number: 20040077034
    Abstract: A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more amino acid substitutions selected form M73T, S79E, V275I, L277K, C281Y, G300V, N304K, I305L and I305M.
    Type: Application
    Filed: November 21, 2003
    Publication date: April 22, 2004
    Applicant: Synmax Biochemical Co., Ltd.
    Inventors: Yang Yunn-Bor, Wei Chia-Li, Hsu Jyh-Shing, Tsai Ying-Chieh
  • Mutated penicillin expandases
    Patent number: 6699699
    Abstract: A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more amino acid substitutions selected from M73T, G79E, V275I, L277K, C281Y, G300V, N304K, I305L and I305M.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: March 2, 2004
    Assignee: Synmax Biochemical Co., Ltd.
    Inventors: Yang Yunn-Bor, Wei Chia-Li, Hsu Jyh-Shing, Tsai Ying-Chieh