Abstract: The invention relates to conjugates of an antigen coupled to a linear derivative of a ?-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups of preferred peptides are derived from the antibiotics protegrin and tachyplesin.
Type:
Grant
Filed:
October 15, 2002
Date of Patent:
January 1, 2008
Assignee:
SYNT:EM S.A.
Inventors:
Mark Elliott Johnson, Fiona Hamilton Day, Michel Kaczorek, Jamal Temsamani
Abstract: The present invention is concerned with a computer-aided method for the provision, identification and description of molecules exhibiting a desired behaviour, more particularly in the pharmaceutical sector, employing a molecular modelling step, a combinatorial library building step and a step of selecting potentially useful molecules, said method including a step whereby the candidate molecules are filtered using a dynamic filter representing constraints of conformational variations which the molecules must satisfy in order to exhibit said activity.
Abstract: Peptides containing or composed of an antibiotic peptide derivative by (i) modifying the cysteine residues such that the peptide is free of disulphide bridges, (ii) substituting 1 to 18 and, preferentially, 1 to 6 amino acids and/or permuting at least one amino acid pair, the substitutions and/or permutation being such that the peptide is amphipathic in nature, and a compound formed from at least one of the peptides bound directly or indirectly to at least one active substance.
Type:
Application
Filed:
January 3, 2003
Publication date:
October 2, 2003
Applicant:
SYNT:EM S.A.
Inventors:
Guillaume Drin, Jerome Gomar, Jamal Temsamani, Anthony R. Rees