Abstract: The present invention relates to a process for the purification of amorolfine hydrochloride by means of a reversed-phase preparative high performances liquid chromatography (prep-HPLC) said method starting from a crude Amorolfine hydrochloride having purity higher than 90% and containing Bepromoline hydrochloride <5% and Fenpropimorf <3%. The process involves the use of a mobile phase comprising water and an organic solvent under isocratic conditions.
Type:
Application
Filed:
February 18, 2010
Publication date:
December 8, 2011
Applicant:
SYNTECO S.P.A.-PRODOTTI DI SINTESI PER L'INDUSTRIA CHIMICA E FARMACEUTICA
Inventors:
Roberto Angeli, Marco Possenti, Salvatore Demartis