Patents Assigned to Syntex Inc.
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Patent number: 7547204Abstract: The present invention provides a nano-precision sintering system 1 for sintering a nano-sized powder of a material in the pulse energization and pressure sintering process to obtain a highly purified sintered compact having a nano-sized grain structure, said nano-precision sintering system 1 comprising: at least one pre-process chamber 20 defined by at least one sealed housing 21 having at least one glove and designed to be controlled into a predetermined atmosphere; a sintering process chamber 30 defined by a sealed housing 31 having at least one glove and designed to be controlled into a predetermined atmosphere; a shut-off system 26 disposed in a passage providing communication between the pre-process chamber and the sintering process chamber so as to block the communication between the two chambers selectively while keeping it in an air tight condition; and a pulse energization and pressure sintering machine 50 having a vacuum chamber āCā allowing for the sintering process to be carried out under a vacuumType: GrantFiled: November 2, 2005Date of Patent: June 16, 2009Assignee: SPS Syntex Inc.Inventors: Masao Tokita, Shinichi Suzuki, Katsuyuki Nakagawa
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Patent number: 6306892Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R 5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.Type: GrantFiled: June 21, 2000Date of Patent: October 23, 2001Assignees: Agouron Pharmaceuticals, Inc., Syntex Inc.Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
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Patent number: 6265192Abstract: A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith.Type: GrantFiled: March 20, 1998Date of Patent: July 24, 2001Assignees: The Regents of the University of California, Syntex, Inc.,Inventors: Annette Bistrup, Steven D. Rosen, Stefan Hemmerich
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Patent number: 5750343Abstract: This invention relates to use of oligonucleotides having at least one nucleotide that is substituted at the 4'-position of the sugar moiety with a substituent other than hydrogen as nucleotide probes in methods for detecting the presence or amount of a polynucleotide analyte in a sample suspected of containing the polynucleotide analyte. These oligonucleotides can also be packaged in diagnostic assay kits.Type: GrantFiled: May 2, 1995Date of Patent: May 12, 1998Assignee: Syntex Inc.Inventors: Hans Maag, Samuel J. Rose, Beat Schmidt
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Patent number: 5250535Abstract: Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen or --C(O)R.sup.7 wherein R.sup.7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof;R.sup.2 is --C(O)R.sup.7 wherein R.sup.7 is as defined above;R.sup.3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R.sup.8 wherein R.sup.8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and(a) R.sup.6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR.sup.9 R.sup.10 wherein R.sup.9 and R.Type: GrantFiled: December 22, 1982Date of Patent: October 5, 1993Assignee: Syntex Inc.Inventors: Julien P. H. Verheyden, John C. Martin
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Patent number: 5055451Abstract: Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:n is 0 or 1;m is 0, 1 or 2;X is H or an N-protecting group;each Y is independently an optionally protected .alpha.-amino acid residue;R is an optionally protected .alpha.-amino acid side chain that is H or CH.sub.3 or that is bonded to the .alpha.-carbon atom to which it is attached by a methylene, methine or phenyl radical; andR' is optionally substituted aryl.Type: GrantFiled: December 7, 1987Date of Patent: October 8, 1991Assignee: Syntex Inc.Inventors: Alexander Krantz, Heinz W. Pauls, Roger A. Smith, Robin W. Spencer
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Patent number: 4886745Abstract: The present invention is concerned with novel monoclonal antibodies specific for an antigenic site on a protein characteristic of a human basal cell and a malignant squamous cell. The antibodies do not bind to mesenchymal cells such as fibroblasts and endothelial cells. The protein on the cell surface which binds to one of the antibodies has a molecular weight of about 120,000 as determined by one dimensional gel electrophoresis. The antibodies find use in diagnostic methods such as the detection of malignant cells, e.g., the detection of residual tumor cells in skin subjected to microscopically-controlled surgery.Type: GrantFiled: March 30, 1984Date of Patent: December 12, 1989Assignee: Syntex Inc.Inventor: Vera Morhenn
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Patent number: 4835288Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetone-dicarboxylates.Type: GrantFiled: January 14, 1987Date of Patent: May 30, 1989Assignee: Syntex Inc.Inventors: Hiralal N. Khatri, Michael P. Fleming, George C. Schloemer
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Patent number: 4529003Abstract: A manifold is described, for delivery of radioaerosol to a patient, having a pair of rigid conduits joined at one end to form a first connector and at the other end to form a second connector. A third connector is formed in the first conduit between the first and second connectors and a one way-valve is located between the first and third connector. A second one-way valve is located in the second conduit to permit exhalation by the patient.Type: GrantFiled: March 21, 1983Date of Patent: July 16, 1985Assignee: Syntex, Inc.Inventors: Vincent F. Iannuzzelli, Carl P. Kremer, Jr.
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Patent number: 4341767Abstract: Nonapeptide and decapeptide analogs of LHRH which have the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein: X is a D-alanyl residue wherein one hydrogen on C-3 is replaced by:(a) a carbocyclic aryl-containing radical selected from the group consisting of phenyl substituted with three or more straight chain lower alkyl groups, naphthyl, anthryl, fluorenyl, phenanthryl, biphenylyl and benzhydryl; or(b) a saturated carbocyclic radical selected from the group consisting of cyclohexyl substituted with three or more straight chain lower alkyl groups, perhydronaphthyl, perhydrobiphenylyl, perhydro-2,2-diphenylmethyl, and adamantyl; or(c) a heterocyclic aryl containing radical selected from the group consisting of radicals represented by the following structural formulas: ##STR2## wherein A" and A' are independently selected from the group consisting of hydrogen, lower alkyl, chlorine, and bromine, and G is selected from the group consisting of oxygen, nitrogen, and sulfur;A is an aminoacType: GrantFiled: October 6, 1980Date of Patent: July 27, 1982Assignee: Syntex Inc.Inventors: John J. Nestor, Gordon H. Jones, Brian H. Vickery
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Patent number: 4270903Abstract: A dental tool for generating a relatively smooth surface on tooth enamel comprises an elongated shank with an operative end and an end adapted to engage a chuck of a dental handpiece. Any cross-section of the operative end perpendicular to the shank's longitudinal axis is circular with a diameter of less than 0.140 inch. Adjacent, continuous annular grooves extend around the operative end, each groove being defined by a pair of inwardly sloping side surfaces intersecting with each other at least about 0.010 inch from the shank's longitudinal axis and forming an included angle of 60.degree. to 150.degree. between the side surfaces. An abrasive material, such as diamond grit, having a particle size of less than 0.006 inch covers at least a portion of each surface.Type: GrantFiled: September 17, 1979Date of Patent: June 2, 1981Assignee: Syntex Inc.Inventor: John E. Nash
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Patent number: 4208423Abstract: Compounds of the formula ##STR1## where R.sup.1 and R.sup.2 are the same or different and are C.sub.1 to C.sub.6 alkyl; C.sub.5 or C.sub.6 cycloalkyl; C.sub.5 or C.sub.6 cycloalkenyl; phenyl optionally substituted with a substitutent selected from the group C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy and halo; or C.sub.4 or C.sub.5 heterocyclic aryl, the heteroatom selected from the group oxygen, nitrogen and sulfur; Y is the radical selected from (CH.sub.2).sub.n, (C.sub.4 H.sub.8 S), (C.sub.4 H.sub.8 O) and ##STR2## where R is hydrogen or C.sub.1 to C.sub.6 alkyl and n is the integer 4 or 5; and X is selected from the group methanesulfonate, benzenesulfonate, p-toluenesulfonate, nitrate, chloride, bromide and iodide. Methods for preparing these compounds are also disclosed. The compounds of the present invention are useful as anticholinergic agents.Type: GrantFiled: November 24, 1978Date of Patent: June 17, 1980Assignee: Syntex Inc.Inventor: Jurg R. Pfister
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Patent number: 3946031Abstract: Novel 2-substituted-1,2,4-thiadiazolo-[ 2,3-a]-benzimidazoles of the formula ##SPC1##And the pharmaceutically acceptable salts thereof; and process for their preparation. These 2-substituted-1,2,4-thiadiazole-[2,3-a]-benzimidazoles are useful as fungistatic and fungicidal agents.Type: GrantFiled: November 14, 1974Date of Patent: March 23, 1976Assignee: Syntex Inc.Inventor: Colin C. Beard