Abstract: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein X is —S(O)n— or —C(O)—, A is C1-6alkyl, aryl, heteroaryl, hydroxyalkyl, or —(CH2)p—NRaRb, and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
Type:
Grant
Filed:
January 31, 2003
Date of Patent:
February 8, 2005
Assignee:
Syntex LLC
Inventors:
Robert Greenhouse, Saul Jaime-Figueroa, Lubica Raptova
Abstract: This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin D3 analogs of Formula (I):
compositions comprising the analogs, methods of preparing the analogs and methods of treatment of osteoporosis, secondary hyperparathyroidism, cancer and autoimmune diseases using such analogs.
Type:
Grant
Filed:
September 3, 1998
Date of Patent:
December 10, 2002
Assignees:
Syntex LLC, Hoffmann-La Roche Inc.
Inventors:
Percy Sarwood Manchand, Milan Radoje Uskokovic