Patents Assigned to Syntex (U.S.A.) LLC
  • 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
    Patent number: 6319920
    Abstract: This invention relates to muscarinic receptor antagonist compounds selected from the group of compounds represented by Formula I: wherein the substituents are as defined in the specification; and their pharmaceutically acceptable salts, individual isomers or a racemic or non-racemic mixture; pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: November 20, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Joan Marie Caroon, Robin Douglas Clark, Michael Patrick Dillon, Ralph New Harris, III, Sharathchandra Surendra Hegde, Clara Jeou Jen Lin, Hans Maag, David Bruce Repke
  • P38 MAP kinase inhibitors
    Patent number: 6316464
    Abstract: The present invention relates to compounds of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: November 13, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Soan Cheng, David Michael Goldstein, Teresa Alejandra Trejo Martin, Eric Brian Sjogren
  • Pyrazole derivatives P-38 MAP kinase inhibitors
    Patent number: 6316466
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: November 13, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
  • T-type calcium channel variants; compositions thereof; and uses
    Patent number: 6309858
    Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: October 30, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paul Shartzer Dietrich, Joseph Gerard McGivern
  • Treatment of emphysema using RARy selective retinoid agonists
    Patent number: 6300350
    Abstract: This invention provides methods of treating emphysema and other diseases associated with alveolar damage by treatment with an RAR&ggr; selective agonist. In another aspect, this invention provides methods of promoting tropoelastin gene expression and alveolar matrix repair by contacting the pulmonary intestitial fibroblast with an RAR agonist, preferably an RAR&ggr; selective agonist.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: October 9, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paula Nanette Belloni, Michael Klaus
  • Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain
    Patent number: 6262078
    Abstract: Compounds selected from the group of compounds represented by Formula I: as an individual isomer or as a racemic or non-racemic mixture of isomers, and their pharmaceutically acceptable salts and N-oxides thereof; are sodium channel blockers, and thus exhibit useful pharmacological properties, including utility for the treatment of neuropathic pain conditions.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: July 17, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Garrett Loughhead, Xiao-Fa Lin, Robert James Weikert, Lee Allen Flippin
  • Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
    Patent number: 6258819
    Abstract: This invention relates to compounds which are generally alpha1A/B-receptor antagonists and which are represented by Formula I: wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and a process for their preparation.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: July 10, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Robin Douglas Clark, Counde O'Yang
  • Process for the preparation of enteric coated pharmaceutical dosage forms
    Patent number: 6224911
    Abstract: This invention is directed to a process for the preparation of enteric coated pharmaceutical dosage forms. This invention is further directed to the aqueous enteric coating dispersions suitable for use in the process and the enteric coated pharmaceutical dosage forms prepared by the process.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: May 1, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Zakauddin T. Chowhan, Patrick H. Vo
  • Preparation of ketorolac
    Patent number: 6197976
    Abstract: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxamides of the formula where R1 is alkyl and R2 is optionally substituted phenyl, and the method for their preparation and their conversion to ketorolac and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: March 6, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Peter J. Harrington, Hiralal N. Khatri, George C. Schloemer
  • Nucleic acids encoding truncated forms of inhibitory kappa B protein
    Patent number: 6194175
    Abstract: Truncated forms of inhibitory kappa B protein (I&kgr;B-&agr;), nucleic acids encoding the truncates, expression and delivery vectors, and therapeutic and prophylatic uses thereof are provided.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: February 27, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paula Nanette Belloni, Gary Allen Peltz