Patents Assigned to Syntex (U.S.A.)
  • Patent number: 4041173
    Abstract: A compound selected from the group of compounds represented by the formula ##STR1## R is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer of 2 to 4 inclusive and R.sup.4 and R.sup.5 are independently lower alkyl of 1 to 6 carbon atoms inclusive or together R.sup.4 and R.sup.5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 to 6 total ring atoms;R.sup.1 is at the 7, 8 or 9 position and is halogen, hydroxy, lower alkoxy of 1 to 6 carbon atoms inclusive, or lower alkyl of 1 to 4 carbons atoms, inclusive;The dotted lines may be an additional, optional bond between the carbon atoms at the 10- and 11 positions; andThe pharmaceutically acceptable salts thereof. The compounds are used pharmaceutically to treat allergic reactions and autoimmune diseases.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: August 9, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, Karl G. Untch
  • Patent number: 4039677
    Abstract: Novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole ring by an optionally substituted hydrocarbyl carbonate or a mono-, di-, or trithiocarbonate are useful as antimicrobial agents and as intermediates in the preparation of novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole with a mercapto. Both the former and latter compounds are useful as intermediates in the preparation of certain 1-[.beta.-(R-thio)phenethyl]imidazoles.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: August 2, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4038299
    Abstract: 2-Substituted-5-oxo-5H-dibenzo [a,d] cycloheptenes represented by the following formula: ##STR1## where one of R.sup.2 and R.sup.3 is hydrogen, and the other is hydrogen, methyl, or ethyl, or together R.sup.2 and R.sup.3 are methylene; the dotted line represents an optional, additional bond between the carbon atoms at the 10- and 11-positions; and the pharmaceutically acceptable esters and ethers thereof. The compounds have anti-inflammatory, analgesic, and antipyretic activities and, accordingly, are useful in the treatment of inflammation, pain and pyrexia.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 26, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, Karl G. Untch
  • Patent number: 4038409
    Abstract: Novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole ring by an optionally substituted hydrocarbyl ester, thioester, or dithioester are useful as antimicrobial agents and as intermediates in the preparation of novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole with a mercapto. Both the former and latter compounds are useful as intermediates in the preparation of certain 1-[.beta.-(R-thio)phenethyl] imidazoles.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: July 26, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036973
    Abstract: Compounds of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is alkyl or the group ##STR2## IN WHICH N IS 0 TO 3 AND THE OTHER OF R.sup.1 and R.sup.2 is benzyl, substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substituted on the phenyl ring with one or more substituents independently selected from the group consisting of halo, lower alkyl and trifluoromethyl; X and Y are independently oxygen or sulfur with the proviso that Y is not oxygen when R.sup.2 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036876
    Abstract: Novel 18.xi.-hydroxylated and 19.xi.-hydroxylated prostaglandins and novel microbiological process for the production thereof.
    Type: Grant
    Filed: July 13, 1973
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Raymond P. Lanzilotta
  • Patent number: 4036974
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl or the group ##STR2## IN WHICH N IS 0 TO 3; X and Y are independently oxygen or sulfur; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036970
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently benzyl substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substituted on the phenyl ring with one or more substituents independently selected from the group consisting of halo, lower alkyl and trifluoromethyl; X and Y are independently oxygen or sulfur with the proviso that Y is not oxygen when R.sup.2 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036176
    Abstract: This invention is an apparatus and process for culturing aquatic animals. The apparatus comprises a container suitable for retaining water; a plurality of platforms vertically spaced from each other located in said container, the platforms being substantially parallel to each other and being designed to allow water to circulate therethrough while at the same time allowing solid food particles when dropped into the platform area to pass therethrough; and a feeding station placed on each of the platforms in a manner so that each feeding station is vertically and horizontally spaced from each adjacent station, has a structure such that the solid food particles are retained on the feeding station, and is substantially the same area as the adjacent feeding station.
    Type: Grant
    Filed: November 20, 1975
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: James C. McCarty, Dominick Mendola
  • Patent number: 4035509
    Abstract: 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer from 2 to 4, inclusive, and R.sup.4 and R.sup.5 are independently lower alkyl having 1 to 6 carbon atoms or together R.sup.4 and R.sup.5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 or 6 total ring atoms; and the pharmaceutically acceptable salts thereof. The compounds are useful in the treatment of auto-immune diseases and allergic reactions.
    Type: Grant
    Filed: March 31, 1975
    Date of Patent: July 12, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, Karl G. Untch
  • Patent number: 4033978
    Abstract: 3-Carboxy-5-substituted-thiacycl[2.2.2]azines of the formula: ##STR1## wherein R is phenyl or phenyl monosubstituted in the meta or para position with fluoro, chloro, lower alkyl of from 1 to 4 carbon atoms or lower alkoxy of from 1 to 4 carbon atoms, and the pharmaceutically acceptable salts thereof.These compounds are useful as anticomplimentary agents, specifically for the treatment of inflammatory conditions, auto-immune diseases, allergic reactions and vascular diseases.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: July 5, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Karl G. Untch, John O. Gardner
  • Patent number: 4032789
    Abstract: An axial tomographic system having scanner means normally in an "off" condition where all power sources associated therewith are electrically isolated from the units driven thereby, means for activating the scanner means to establish an "on" condition, control means including means to measure one or more system parameters when the scanner means is in an "on" condition and to determine if the measured parameters are within predetermined limits therefor, and means for maintaining the "on" condition only if the control means is properly operational and all measured system parameters are within the predetermined limits therefor.
    Type: Grant
    Filed: October 28, 1975
    Date of Patent: June 28, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Samuel Thomas Workman
  • Patent number: 4031234
    Abstract: This application relates to 1,5(6)-disubstituted benzimidazole-2-carbamate derivatives represented by the following formula: ##STR1## where R is lower alkyl having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 ; R.sup.2 is lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, or aralkyl or aryl; R.sup.5 is lower alkenyl, lower alkynyl or aralkyl; R.sup.7 is lower alkyl having 1 to 4 carbon atom, or aryl; M and M' are independently O, S, ##STR2## n is 1-4; and R.sup.8 is lower alkyl having 1 to 12 carbon atoms optionally substituted with a --COOR group where R is lower alkyl having 1 to 4 carbon atoms, aryl or aralkyl. The R.sup.1 substitution is at the 5(6)-position.The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.
    Type: Grant
    Filed: June 18, 1976
    Date of Patent: June 21, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Colin C. Beard, John A. Edwards, John H. Fried
  • Patent number: 4031228
    Abstract: Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; and R.sup.1 is a fused, bicyclic heterocyclic ring moiety. The R.sup.1 S-substitution is at the 5(6)-position.The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents. The compounds are also useful as antiprotozoal agents, particularly against Trichomonas vaginalis.
    Type: Grant
    Filed: March 22, 1976
    Date of Patent: June 21, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Colin C. Beard
  • Patent number: 4029773
    Abstract: Compositions and method for treating, or reducing the occurrence, of stomach and duodenum ulcers. The compositions and methods are characterized by the administration of a composition containing (dry weight basis) 10 to 40% sucrose; 10 to 40% glucose; 12 to 20% amino acids and 7.5 to 12% lipids. The composition is typically administered orally as an aqueous liquid emulsion.
    Type: Grant
    Filed: May 25, 1973
    Date of Patent: June 14, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Myron A. Beigler, Ronald J. Amen
  • Patent number: 4020094
    Abstract: 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer from 2 to 4, inclusive, and R.sup.4 and R.sup.5 are independently lower alkyl having 1 to 6 carbon atoms or together R.sup.4 and R.sup.5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 or 6 total ring atoms; one of R.sup.2 and R.sup.3 is hydrogen and the other is hydrogen, methyl, or ethyl, or together R.sup.2 and R.sup.3 are methylene; and the pharmaceutically acceptable salts thereof. The compounds have anti-inflammatory, analgesic, and antipyretic activities and, accordingly, are useful in the treatment of inflammation, pain and/or pyrexia.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: April 26, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, Karl G. Untch
  • Patent number: 4019966
    Abstract: Method of and apparatus for the amperometric determination of the concentration of arendiazonium salts in a diazocoupling reaction mixture. The apparatus has an external body in the bottom part of which cleaning material is disposed, a shaft, an inner body mounted on the shaft, at least two electrodes located in the inner body, a commutator, each of the electrodes being independently connected with one segment of the commutator. The commutator forms a component part of the shaft of the inner body; an electric motor is connected with the shaft to drive the inner body, compression bearings with a spring and an adjusting screw being disposed for adjustment of the compressive force between the inner body with its electrodes and the cleaning material. Brushes cooperate with the commutator for alternately connecting spaced pairs of electrodes on the inner body of the measuring circuit and disconnecting them therefrom.
    Type: Grant
    Filed: June 4, 1976
    Date of Patent: April 26, 1977
    Assignee: Vyzkumny ustav organickych syntex
    Inventors: Miroslav Remes, Miroslav Matrka, Zdenek Sagner
  • Patent number: 4017615
    Abstract: An ointment vehicle containing from 0.5 to 30 percent propylene carbonate, from 30 to 99.5 weight percent petrolatum and/or polysiloxane, compatible cosolvent, the concentration of which in combination with propylene carbonate is from 0.5 to 70 percent, and, optionally, surfactants, thickeners, preservatives, and penetrants. This ointment is a suitable vehicle for all types of therapeutic agents for topical application including antibiotics, steroids, antihistamines, antiseptics, anesthetics, antibacterials, fungicides and the like, and has shown particular advantages with anti-inflammatory topical corticoids.
    Type: Grant
    Filed: December 11, 1975
    Date of Patent: April 12, 1977
    Assignee: Syntex Corporation
    Inventors: Subramaniam Shastri, Zafaruzzaman I. Shaikh
  • Patent number: 4014336
    Abstract: An inhalation device having an elongate housing having one or more passageways for the passage of air therethrough. Each passageway, of relatively small diameter, opens into an emptying chamber, of relatively greater diameter, adjacent that end of the housing which is adapted for insertion into the mouth or nose of a user. Adjacent that end of the emptying chamber closest to the passageway(s), the housing has means for receiving or presenting a unit dose of powdered medicament for administration. Means are provided to open the medicament holder as it is being inserted into, or after it has been inserted into, the means for receiving or presenting a unit dose of powdered medicament for administration. During inhalation, the air stream passing over and directed into the powdered medicament holder entrains the powdered medicament which is then carried into the nose, throat or lungs of the user where beneficial or therapeutic action of the medicament occurs.
    Type: Grant
    Filed: November 20, 1975
    Date of Patent: March 29, 1977
    Assignee: Syntex Puerto Rico, Inc.
    Inventor: Stanley Mathes
  • Patent number: 4011241
    Abstract: 2-(5H-Dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids, are prepared from glycidonitrile intermediates. The acid products exhibit anti-inflamatory, analgesic and anti-pyretic activity.
    Type: Grant
    Filed: September 8, 1975
    Date of Patent: March 8, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, Karl G. Untch