Abstract: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.

Abstract: An orthopedic implant comprising a metallic substrate coated with a diamond-like carbon (DLC) layer, and a layer of a polymeric material placed over the DLC layer that is less stiff than the substrate, and methods of manufacturing the same.

Abstract: A multi-level spine stabilization system comprises a plurality of securing members configured for attachment to a plurality of vertebrae. A plurality of adjustable rods segments extend between the plurality of securing members. The adjustable rod comprises a first rod segment that engages a second rod segment in an adjustable relationship. The length of the rod may be adjusted by moving the first rod segment relative to the second rod segment. For example, the first rod segment may be in a slideable relationship with the second rod segment such that sliding the first rod segment relative to the second rod segment results in a change in the length of the rod. In one embodiment, portions of both the first rod segment and the second rod segment are positioned within and secured to the securing member. Advantageously, the multi-level spine stabilization system described herein may be used to center dynamic portions of the rod between securing members.

Abstract: A bone plate system includes (a) Bone Plate having a bottom surface for contacting bone, an upper surface and at least one through hole extending from the bottom surface to the upper surface, the through hole having a central axis and a cross-section that extends orthogonally to the central axis and is one of at least partially polygonal, at least partially prismatic, and at least partially elliptical; (b) Bushing within the through hole, Bushing including a central bore designed to receive a bone fixation element, a cross-section of Bushing orthogonal to the longitudinal axis of Bushing is shaped substantially the same as the cross-section of the through hole so that Bushing is secured against rotation about its longitudinal axis; and (c) at least one Bone Fixation Element having a portion for anchoring within bone, Bone Fixation Element configured and dimensioned for insertion into the central bore of Bushing.

Abstract: Disclosed is an expandable interbody fusion implant that is configured to have an initial configuration having a first footprint width suitable for being inserted into an intervertebral space and an expanded configuration having a second footprint width that is greater than the first footprint width. The implant may include a first body member and a second body member that is pivotally coupled to the first body member. The implant may be expanded using an inflatable balloon. The implant may be expanded bilaterally such that both body members rotate relative to the other or the implant may be expanded unilaterally such that one of the body members rotates relative to the other.

Abstract: Oscillating rasps for the surgical preparation of the bone prior to the implantation of a glenoid or acetabular component with complex geometry are disclosed. Surgical methods for the use of such oscillating rasps are also disclosed. The oscillating rasp includes an attachment head configured to be secured in a chuck of an oscillating tool, and a cutting head secured to the attachment head. The cutting head includes a cutting surface extending posteriorly from the longitudinal axis of the oscillating surgical rasp. The cutting surface has a plurality of cutting teeth arranged in a geometry that, when oscillated along a predetermined path in contact with the glenoid of the patient, corresponds with the geometry of the augmented glenoid prosthesis.

Abstract: A method and system for insertion of an implant is disclosed. One embodiment of a system for use in implanting a spinal prosthesis incorporating principles of the invention includes an insertion assembly housing with a channel extending from a distal end portion to a proximal end portion, a gripper having a prosthesis coupling portion for coupling with a spinal prosthesis and an end portion, and a coupler member having a gripper coupling portion rotatably positioned within the channel and configured to couple with the end portion of the gripper within the channel.

Abstract: A bone graft applicator for applying bone graft to an orthopaedic implant. The bone graft applicator includes a pair of arms and a bone graft receptacle sized and shaped to be able to receive a portion of the orthopaedic implant within the receptacle. The bone graft receptacle is coupled to each of the pair of arms. The bone graft applicator also includes a linking mechanism. The linking mechanism includes a recess sized and shaped to extend at least partially around the portion of the orthopaedic implant and is coupled to the bone graft receptacle.

Abstract: A modular glenoid assembly. The modular glenoid assembly includes a base having a first side and an opposing second side, the first side including a plurality of connection features arranged in an array. At least one glenoid attachment member is included. The glenoid attachment member has a locking mechanism sized and shaped to lock the glenoid attachment member in at least one of the plurality of connection features on the base.

Abstract: An orthopaedic prosthesis includes a tibial bearing and a femoral component configured to articulate with the tibial bearing. The tibial bearing and the femoral component are configured to promote outward axial rotation of the femoral component on the tibial component during knee flexion.

Abstract: Devices and methods useful for storing and retrieving information related to a medical device such as an implantable valve or an implantable sensor are disclosed. An implantable valve can include a valve housing adapted to receive fluid flow therethrough between a valve inlet and a valve outlet. A valve assembly can be disposed within the valve housing and adapted to control a rate of fluid flowing through the valve housing. The implantable valve can also include a radio frequency identification (RFID) tag associated with the valve housing, adapted to store data, and including an antenna for communicating stored data to an external reading device. The RFID tag can store data related to, for example, a patient, a pressure setting of the valve assembly, and/or pressure sensor disposed within the valve. The RFID tag can also store an identifier that identifies the implantable valve, a pressure sensor disposed in the valve housing, a patient associated with the implantable valve, and/or patient clinical history.

Abstract: A device for measuring blind holes formed through a bone includes (a) a first elongated rod including a shaft extending from a proximal end to a distal end, the distal end including an increased diameter abutment extending radially outward therefrom, the abutment including a proximal surface formed to contact a portion of the bone adjacent a distal opening of the blind hole to assume a locked configuration with the bone and (b) a second elongated rod extending from a proximal end to a distal end along a longitudinal axis.

Abstract: A system is provided for inserting and securing, through a suprapatellar region of a leg, a nail into a medullary canal of a bone. The system can include a flexible sleeve configured to be partially inserted in the leg. The flexible sleeve can define a leading end and a trailing end spaced apart from the leading end along a first axis. The flexible sleeve can define a first cannulation that extends along the first axis between the leading and trailing ends. The first cannulation can be sized to receive therethrough at least the intramedullary nail. The system can further include a retaining member configured support at least a portion of the flexible sleeve. The retaining member can be configured to position the flexible sleeve through the suprapatellar region of the leg such that the flexible sleeve leading end is aligned with the proximal end of the bone. The intramedullary nail can be insertable through the flexible sleeve and into the medullary canal.

Abstract: A flexible body comprises a polymer film having a first surface and an opposing second surface. The polymer film has a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by one of the plurality of raised lips. A method of producing a polymer film comprises placing a polymer solution into a one sided mold having a plurality of protrusions extending from a bottom of the mold wherein the polymer solution is characterized by a viscosity that inhibits the unaided flow of the polymer throughout the mold; urging the polymer solution around each of the plurality of protrusions; and solidifying the polymer solution.

Abstract: Biomedical implants (e.g., orthopedic implants) with modified surfaces that can enhance a cement bond's strength (e.g., tensile, shear, and/or fatigue) are disclosed, along with methods of manufacturing and using such implants. The implants can exhibit a variety of physical, chemical, or process-derived features which can enhance cement bonding. For instance, the implant surface can exhibit particular roughness values, and/or be substantially free of non native material. Processes for producing such implants can include providing a first roughened implant surface, which can be produced, for example, by particle blasting. A treatment formulation can be applied to the first roughened surface to create a second roughened surface that exhibits enhanced cement bonding properties relative to the first roughened surface. In some instances, the first roughened surface and the second roughened surface can exhibit substantially similar Ra values. The second roughened surface can exhibit a negative Rsk value.

Abstract: A connector for connecting a first spinal rod to a second spinal rod includes a body having a first end and a second end spaced apart from the first end. The first end of the body has a first rod opening formed therein for receiving the first spinal rod and the second end has a second rod opening formed therein for receiving the second rod. The body of the connector has a passage extending between the first opening and the second opening. The body of the connector has a plurality of spaced apart adjustment openings oriented along the length of the body between the first end and the second end, the adjustment openings communicating with the passage to facilitate adjustment of the first and second spinal rods within the passage.

Abstract: An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula.

Abstract: A method is for connecting an outrigger to a clamp in an external fixation system. A moveable member and a slide lock are couplied to an elongated member of the outrigger. The elongated member has a length, a distal end, a proximal end and a threaded portion on the distal end. The threaded portion has a keyed portion. The moveable member is moveable along the elongated member. The slide lock has a keyed portion and an engagement surface. The distal end of the elongated member is coupled to an opening of the clamp such that the engagement surface of the slide lock engages a portion of the clamp. The keyed portion of the threaded portion and the keyed portion of the slide lock are operably associated with each other to permit longitudinal movement of the slide lock along the length of the elongated member while preventing rotation. The engagement surface of the slide lock has a non-smooth texture and faces in a direction that is away from the moveable member.

Abstract: A method of expanding the spinal canal of a vertebra including inserting a bone anchor into a first lamina of the vertebra, cutting completely through the first lamina to create a space in the first lamina, cutting partially through a second, contra-lateral lamina of the vertebra to create a partial cut in the second lamina, engaging a first segment of a plate with the bone anchor, pivoting the bone anchor and the first lamina about the partial cut in the second lamina to increase the extent of the space in the first lamina, and connecting a second segment of the plate to a portion of the vertebra across the space from the first segment of the plate such that the plate spans the space and stabilizes the vertebra.