Abstract: A cannulated fastener system is provided for orthopedic applications that include attaching bone plates to bone. The bone fastener has a cannulation with an inner shape. One or more screwdrivers is provided with a shaft having a shape that matches the cannulation of the fastener to rotationally fix the fastener to the screwdriver. In addition, the screwdrivers have a cutting blade that begins the drilling of a hole for the bone fastener. The screwdrivers may either be for use with a single fastener or have multiple fasteners loaded within a retaining sleeve for automatic or controlled dispensing.

Abstract: A surgical drill guide for use with a bone plate having fastener holes oriented at predetermined angles with respect to the plate, the surgical drill guide having at least one alignment drill guiding barrel that is aligned with the respective fastener holes in the bone plate for drilling the holes at the desired range of angles permitted by the plate hole.

Abstract: A modular intervertebral implant or a modular intervertebral disk prosthesis has a middle piece or central section equipped with elements for detachable fixation to one or two apposition plates designed to rest against the base plate or cover plate of an intervertebral body. A modular kit of such modular implants or disks includes n central sections and m apposition plates, where n=2 and m=4 and preferably n=3 and m=6. The surfaces of the apposition plates that face the central section have elements complementary to the elements for detachable fixation on the central section.

Abstract: A minimally invasive fixation system and method for providing access to a surgical site. The fixation system may include a holding assembly, the holding assembling preferably including a lateral implant holder which may be attached to a pedicle screw and a sleeve positioned in connection with the lateral implant holder to prevent the lateral implant holder from separating from the pedicle screw. The sleeve may further include a tissue protection portion to keep the tissue out of the surgical site. A holding sleeve may be operably connected to the holding assembly and pedicle screw and may be used to insert the pedicle screw into the body. Multiple constructs may be inserted into the body so that a portion of the holding assembly extends from the body and provides access to and visualization of the surgical site. A rod holder may also be used to insert a rod into the head of the screw. The rod may be held by the rod holder so that the rod may be angulated as the rod is inserted into the screw heads.

Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.

Abstract: A device for treating spinal stenosis having an implant body structure sized and configured to be positioned between the spinous processes of two adjacent vertebrae. The device may have a body portion having a first end portion, a second end portion and a sleeve between the first and second end portions. The device may also have at least two retainers positioned in and extendable from the body portion. A mechanism positioned within the body portion may be used to move the retainers between a retracted position and a deployed position. When the retainers are in the deployed position, the retainers may be positioned around the spinous process of at least one of two adjacent vertebrae. A plurality of installation tools may be used to install the device.

Abstract: A flexible cable for sternal reconstruction, the cable including first and second ends, the first end of the cable including a crimp fitting member, and the crimp fitting member including a flattened disk-like head. Also provided are methods for sternal reconstruction including wrapping a flexible cable having first and second ends around the sternum, tensioning the flexible cable to a desired tension and securing the tensioned cable, wherein the first end of the cable includes a crimp fitting member, and the crimp fitting member includes a flattened disk-like head.

Abstract: A dynamic stabilization system may include an elongated spinal rod, at least two bone anchors attached to the elongated rod, and a dynamic member. One of the bone anchors allows translation of the spinal rod with respect to the bone anchor. The dynamic member comprises a body and an elastomeric element coupled to at least one side of the body. The body of the element is capable of being attached to the elongated spinal rod between the two bone anchors.

Abstract: A bone fixation system including a bone plate and surgical drill guide is provided. The drill guide assembly includes one or more alignment drill tubes that are remotely aligned with corresponding fastener holes in the bone plate, and a plate holder to engage a hole in the bone plate. The surgical drill guide is releasably lockable to the plate holder.

Abstract: An outrigger having a locking mechanism includes an elongated member having a distal end, a proximal end, and a threaded portion proximate the distal end; a moveable member operably associated with the elongated member; and a slide lock operably associated with the moveable member. The thread portion may have at least one flat side and the slide lock may have at least one flat portion. The at least one flat side and the at least one flat portion may engage such that the slide lock translates along, but not rotate about, the threaded portion. The slide lock may engage a surface of the clamp. The moveable member may move the slide lock towards the clamp such that the engagement portion engages the surface of the clamp. The connection between the engagement portion and the surface of the clamp may prevent the slide lock from rotating relative to the clamp.

Abstract: An apparatus for use with a spinal implant includes a handle structure with a passage. A shaft with a screw thread that is moveable within the passage in the handle structure. A pusher block is linked to the shaft, and has a forward surface configured to engage the spinal implant. A screw-threaded clutch member is supported on the handle structure for movement into and out of engagement with the screw thread on the shaft.

Abstract: Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.

Abstract: The device is used for mutually securing or clamping a longitudinal carrier (e.g., a spinal rod) to a bone fixing element (e.g., a pedicle screw). The device includes a body having a channel that is open along its longitudinal axis on one side for receiving the longitudinal carrier. The body has a bore that extends fully through the body and at least partially intersects the channel. The bore is conical in form and has a large opening, a small opening, and an inner thread. The head of the bone fixing element has an outer thread that corresponds to the inner thread. As the fixing element is secured in the bore, it locks the longitudinal carrier to the device.

Abstract: Thermogelling polymers are described containing poly (n-isopropyl acrylamide). Solutions of this polymer, copolymers or mixtures of the polymer with a second polymer such as poly(ethylene glycol), poly (vinyl pyrrolidone) or poly(vinyl alcohol) are liquids at room temperature and solids at body temperature. Thus, also provided are methods of implanting a hydrogel into a mammal by injecting the solution as a liquid at a temperature below body temperature into a selected site in the mammal at a temperature below body temperature, which then undergoes thermal phase transition to form a solid hydrogel in situ in the body as the implant warms to body temperature. Methods for using these thermal gelling materials in various applications including nucleus pulposus replacement/augmentation, wound care, disk replacement, cartilage replacement, joint replacement, surgical barriers, gastrointestinal devices, cosmetic and reconstructive surgery, and breast enlargement are also provided.

Abstract: A sternal reconstruction system for securing parts of a sternum includes at least one flexible cable with crimp fitting, at least one cannulated screw and at least one reconstruction plate. Circumferential or parasternal fixation may be brought about by use of a sternal reconstruction system including a flexible cable and crimp fitting alone; a sternal reconstruction system including a flexible cable, crimp fitting and cannulated screws; or a system including a flexible cable, crimp fitting, cannulated screws and one or more reconstruction plates. The reconstruction plates are typically planar, having an upper and a lower surface, and containing generally perpendicular and transverse plate holes. The generally perpendicular plate holes are countersunk to better accommodate the heads of the cannulated bone screws. Also provided is a kit for sternal reconstruction.

Abstract: An intervertebral implant including a top part, a bottom part and a joint arranged axially between the top part and the bottom part. The top part includes a top surface suitable to be placed on the base plate of a body of the vertebra adjacent and above the site of removal. The bottom part has a bottom surface suitable to be placed on the cover plate of a body of the vertebra adjacent and below the site of removal. The joint includes a convex joint part with a first articular surface and a joint shell matching it, with a second articular surface mounted in a sliding manner on the first articular surface. The intervertebral implant including a temporarily locking mechanism to fix the two parts relative to one another.

Abstract: A bone screw (1) is used for locking an articular facet between the superior and inferior articular processes of two vertebral bodies and is provided with a threaded shaft (2), a screw head (3) and a central axis (4). The screw head (3) is further provided with a number of grooves (5) on the periphery of the screw head (3) which run essentially parallel to said central axis (4).

Abstract: The present invention provides a clamp assembly which allows the surgeon to snap a bone fixation assembly onto a bone fixation rod at an intermediate location along the length of the rod. It is not necessary to “thread” the clamp onto the rod starting at the end and sliding it down the length of the rod to the desired location. In particular, this invention provides a novel clamp assembly for use with standard bone fixation rods, and bone pins. The clamp allows the interconnection of a bone fixation rod with a bone pin locking assembly including a bone pin vise. The clamp is a single-piece construction, having a jaw capable of loosely capturing the bone fixation rod when the surgeon presses the jaw onto the rod. The assembly may be rigidly fixed to the rod using a bolt which tightens the jaw onto the rod.

Abstract: A bone fixation element (10) for use in spinal fixation facilitates insertion of a longitudinal spinal rod (45) in a rod-receiving channel (26) formed in the bone fixation element. The bone fixation element engages a coated spinal rod, preferably a dynamic spinal rod made from a generally non-biocompatible material such as nickel, cobalt chromium or Nitinol. The bone fixation element preferably incorporates first (120) and second (140) rod protectors to contact the coating on the spinal rod when the rod is received in the rod receiving channel of the hone fixation element. The first and second rod protectors are preferably constructed of a material having a hardness that is less than a hardness of a material of the coated spinal rod.

Abstract: A screwdriver having a retention mechanism for temporarily holding a screw in place on its tip while the screw is being positioned, rotated or removed. More particularly, a screwdriver with a cruciform head used in the installation and removal of bone screws during maxillofacial surgery.