Patents Assigned to Synthesis, Inc.
-
Patent number: 10933051Abstract: The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.Type: GrantFiled: June 11, 2018Date of Patent: March 2, 2021Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Takashi Tomioka, Hyung-Yeul Joo, Phong Truong, Brian Min
-
Publication number: 20190194115Abstract: This invention concerns a method of synthesizing Azelaic Acid. Particular reference is made to providing a new synthetic process for preparing azelaic acid in large scale with high purity (e.g., >99.7% with any individual impurity not more than 0.1%), which can be used as an active pharmaceutical ingredient.Type: ApplicationFiled: December 22, 2017Publication date: June 27, 2019Applicant: PCI Synthesis, Inc.Inventors: Rajesh Thamatam, Bishwabhusan Sahoo, Rajesh Shukla
-
Patent number: 9937151Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.Type: GrantFiled: April 22, 2015Date of Patent: April 10, 2018Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Gruszecka-Kowalik, Hyung-Yeul Joo, Shuangpei Liu, Shuli Mao, Yongfeng Li, Deog-Il Kim
-
Patent number: 9273087Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.Type: GrantFiled: January 19, 2015Date of Patent: March 1, 2016Assignee: Prime Synthesis, Inc.Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
-
Patent number: 9149461Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.Type: GrantFiled: December 13, 2012Date of Patent: October 6, 2015Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Gruszecka-Kowalik, Hyung-Yeul Joo, Shuangpei Liu, Shuli Mao, Yongfeng Li, Deog-Il Kim
-
Patent number: 8956725Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.Type: GrantFiled: December 4, 2013Date of Patent: February 17, 2015Assignee: Prime Synthesis, Inc.Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
-
Publication number: 20140087189Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.Type: ApplicationFiled: December 4, 2013Publication date: March 27, 2014Applicant: Prime Synthesis, Inc.Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
-
Patent number: 8628822Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.Type: GrantFiled: June 24, 2008Date of Patent: January 14, 2014Assignee: Prime Synthesis, Inc.Inventors: Marc L Rothstein, Dianne M Rothstein, Dan P Lee
-
Patent number: 8557979Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ?-methyl carbapenems which are useful as antibacterial agents.Type: GrantFiled: July 27, 2012Date of Patent: October 15, 2013Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Kowalik
-
Publication number: 20130172313Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.Type: ApplicationFiled: December 13, 2012Publication date: July 4, 2013Applicant: FOB SYNTHESIS, INC.Inventor: FOB Synthesis, Inc.
-
Publication number: 20120296084Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ?-methyl carbapenems which are useful as antibacterial agents.Type: ApplicationFiled: July 27, 2012Publication date: November 22, 2012Applicant: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Kowalik
-
Patent number: 8232268Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ?-methyl carbapenems which are useful as antibacterial agents.Type: GrantFiled: February 15, 2010Date of Patent: July 31, 2012Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Kowalik
-
Publication number: 20100160284Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ?-methyl carbapenems which are useful as antibacterial agents.Type: ApplicationFiled: February 15, 2010Publication date: June 24, 2010Applicant: FOB Synthesis, Inc.,Inventors: Woo-Baeg Choi, Ewa Kowalk
-
Patent number: 7683049Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions, wherein the compounds are generally of the Formulae The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.Type: GrantFiled: June 10, 2005Date of Patent: March 23, 2010Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, Ewa Kowalik
-
Patent number: 7632828Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions, wherein the compounds are generally of the Formulae The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ÿ-methyl carbapenems which are useful as antibacterial agents.Type: GrantFiled: June 10, 2005Date of Patent: December 15, 2009Assignee: FOB Synthesis, Inc.Inventors: Woo-Baeg Choi, David S. Menaldino, Deog-Il Kim, Martin Bouygues, Michael W. Hager
-
Publication number: 20090005536Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.Type: ApplicationFiled: June 24, 2008Publication date: January 1, 2009Applicant: Prime Synthesis, Inc.Inventors: MARC L. ROTHSTEIN, Dianne M. Rothstein, Dan P. Lee
-
Patent number: 6799120Abstract: The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.Type: GrantFiled: February 2, 2001Date of Patent: September 28, 2004Assignee: Nanoscale Combinatorial Synthesis, Inc.Inventors: Nikolai F. Sepetov, Olga L. Issakova, Stephen A. Baum, James A. Ostrem
-
Patent number: 6625546Abstract: Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following combinatorial synthesis using molecular mass measurements of individual compounds, thereby eliminating the necessity of encoding synthetic steps. The analysis of mass spectrometric data for sets of related compounds reveals compounds that are missing in a group of related compounds and identifies compounds that do not belong to a group of related compounds due to unexpected chemical, physical, or biological transformations. The methods may be applied to any group of compounds originating from chemical reactions where one reactant is common to the synthetic transformation. One particular application of these methods is in the analysis of the products of combinatorial synthesis. Systems, computer programs products, and kits are additionally provided.Type: GrantFiled: February 2, 2001Date of Patent: September 23, 2003Assignee: Nanoscale Combinatorial Synthesis, Inc.Inventors: Nikolai F. Sepetov, Olga L. Issakova
-
Publication number: 20010041344Abstract: The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.Type: ApplicationFiled: February 2, 2001Publication date: November 15, 2001Applicant: Nanoscale Combinatorial Synthesis, Inc., 625 Clyde Avenue, Mountain View, CA 94043Inventors: Nikolai F. Sepetov, Olga L. Issakova, Stephen A. Baum, James A. Ostrem
-
Patent number: 6006022Abstract: A cross-linked development and deployment system that links system design, simulation, real-time emulation, integration, and in-system verification to system implementation in the field, creating final products that are field programmable systems on printed circuit boards or field programmable systems on silicon. In a preferred embodiment, hardware and software models are created and verified in an integrated co-development environment. These models can be synchronized with each other and can also be used for in-circuit emulation and in-system verification of the system under development. Once the system has gone through verification and completed system integration, the system design database that has been generated from that testing is used to program either a field programmable printed circuit board or a field programmable system on silicon.Type: GrantFiled: November 15, 1996Date of Patent: December 21, 1999Assignee: Microsystem Synthesis, Inc.Inventors: Hotaek Rhim, Russell David Hayden, William Chester Rea