Abstract: The present invention provides an aqueous composition and its use for dissolving blood clots in vivo or in clinical or research samples in vitro, said composition comprising at least one chaotropic agent, at least one chelating agent that complexes iron if the chaotropic agent does not complex iron and at least one surface-active emulsifier, the composition being buffered near pH 7.4. The process of dissolving the clot with the aqueous composition is advantageous because it is simple, inexpensive, rapid and can be applied in a variety of contexts, including basic research and clinical situations.
Type:
Application
Filed:
June 21, 2012
Publication date:
December 27, 2012
Applicant:
SYNTHETECH PHARMACEUTICALS, LLC
Inventors:
John S. Fisher, Fred Ahari, Christopher Jon Perry, Lucjan J.J. Hronowski