Patents Assigned to Synthetic Biologies, Inc.
  • Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
    Patent number: 11596674
    Abstract: This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: March 7, 2023
    Assignee: Synthetic Biologies, Inc.
    Inventors: Michael Kaleko, Sheila Connelly, Vincent John Wacher
  • Beta-lactamases with improved properties for therapy
    Patent number: 11236319
    Abstract: This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract) disorders such as C. difficile infection (CDI).
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: February 1, 2022
    Assignee: Synthetic Biologies, Inc.
    Inventors: Michael Kaleko, Sheila Connelly
  • Modified beta-lactamases and methods and uses related thereto
    Patent number: 11214787
    Abstract: The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and pharmaceutical compositions comprising the beta-lactamases. Also, the present invention relates to methods for modifying a beta-lactamase, producing the beta-lactamase and treating or preventing beta-lactam antibiotic induced adverse effects. Furthermore, the present invention relates to the beta-lactamase for use as a medicament and to the use of the beta-lactamase in the manufacture of a medicament for treating or preventing beta-lactam antibiotics induced adverse effects. Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 4, 2022
    Assignee: Synthetic Biologies, Inc.
    Inventors: Pertti Koski, Ulla Airaksinen, Katja Valimaki
  • Carbapenemases for use with antibiotics for the protection of the intestinal microbiome
    Patent number: 11123413
    Abstract: This invention relates, in part, to various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: September 21, 2021
    Assignee: Synthetic Biologies, Inc.
    Inventors: Michael Kaleko, Sheila Connelly