Patents Assigned to SyntheZyme LLC
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Patent number: 9650405Abstract: A method for the development of a library of modified sophorolipids using a wide-range of chemical and enzyme catalyst tools to identify modified sophorolipids that can be used in pure form, as mixtures with other modified sophorolipids, as mixtures with natural sophorolipids, as mixtures with modified and natural sophorolipids, and as mixtures with other compounds known by one skilled in the art for use in the dispersion, solubilization or emulsification of various oil types and nutraceuticals, and modified sophorolipids for use in dispersion, solubilization or emulsification processes.Type: GrantFiled: May 27, 2013Date of Patent: May 16, 2017Assignee: Synthezyme, LLCInventors: Richard A. Gross, Thavasi Rengathavasi, Amanda Koh, Yifeng Peng
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Patent number: 9359581Abstract: A substantially pure Candida host cell is provided for the biotransformation of a substrate to a product wherein the host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt at least one alcohol dehydrogenase gene in the substantially pure Candida host cell.Type: GrantFiled: November 19, 2013Date of Patent: June 7, 2016Assignee: Synthezyme LLCInventors: Jon E. Ness, Jeremy Minshull
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Publication number: 20150225759Abstract: A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.Type: ApplicationFiled: April 20, 2015Publication date: August 13, 2015Applicant: Synthezyme LLCInventors: Richard A. Gross, Vishal Shah, Frantisek Nerud, Datta Madamwars
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Publication number: 20150218486Abstract: An ?-carboxyl-?-hydroxyl fatty acid oxidized from a substantially pure Candida host cell, wherein the substantially pure Candida host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt an alcohol dehydrogenase gene, and a second genetic modification class, wherein the second genetic modification class comprises an insertion of a first gene into the Candida host cell genome.Type: ApplicationFiled: April 6, 2015Publication date: August 6, 2015Applicant: SYNTHEZYME LLCInventors: JON E. NESS, JEREMY MINSHULL
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Patent number: 9051347Abstract: A composition of matter comprising sophorolipids as antimicrobial agents, antifungal agents, biopesticides, for uses as drugs to treat HIV, septic shock, cancer, asthma, dermatological conditions, as spermicidal agents, as anti-inflammatory drugs, as ingredients in cosmetics and building blocks for monomers and polymers and self-assembled templates for further chemical elaboration.Type: GrantFiled: September 19, 2013Date of Patent: June 9, 2015Assignee: Synthezyme, LLCInventors: Richard A. Gross, Mark H. Schofield
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Patent number: 9012194Abstract: A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.Type: GrantFiled: December 22, 2005Date of Patent: April 21, 2015Assignee: Synthezyme LLCInventors: Richard A. Gross, Vishal Shah, Frantisek Nerud, Datta Madamwars
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Patent number: 8796228Abstract: 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octa-decenoate, lactonic and open ring 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, methyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, hexyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6?-acetate and ethyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6?,6?-diacetate sophorolipids and uses thereof as antifungal agents.Type: GrantFiled: January 27, 2009Date of Patent: August 5, 2014Assignee: Synthezyme, LLCInventors: Richard A. Gross, Vishal Shah
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Publication number: 20140051780Abstract: The present invention relates to aliphatic or aliphatic-aromatic polyesters and copolyesters comprised of biobased ?-hydroxyfatty acids or derivatives thereof, processes for the preparation thereof, and compositions thereof having improved properties. The copolyesters of the present invention may also contain additional components that can be selected from aliphatic or aromatic diacids, diols and hydroxyacids obtained from synthetic and natural sources. The biobased ?-hydroxyfatty acids that comprise the polyesters and copolyesters of the present invention are made using a fermentation process from pure fatty acids, fatty acid mixtures, pure fatty acid ester, mixtures of fatty acid esters, and triglycerides from various sources. The polyesters of the present invention may contain various amounts and types of ?-carboxyfatty acids depending on the engineered yeast strain used for the bioconversion as well as the feedstock(s) used.Type: ApplicationFiled: August 16, 2012Publication date: February 20, 2014Applicant: SyntheZyme LLCInventor: Richard A. Gross
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Patent number: 8648055Abstract: A method for neutralizing or inactivating a virus, and neutralizing or inactivating HIV using sophorolipids having antiviral properties produced by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as an antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an antiviral agent, and sophorolipid compounds for use as antiviral agents.Type: GrantFiled: March 5, 2012Date of Patent: February 11, 2014Assignee: SyntheZyme, LLCInventors: Richard A Gross, Vishal Shah, Gustavo Doncel
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Patent number: 8597923Abstract: A substantially pure Candida host cell is provided for the biotransformation of a substrate to a product wherein the host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt at least one alcohol dehydrogenase gene in the substantially pure Candida host cell.Type: GrantFiled: May 6, 2010Date of Patent: December 3, 2013Assignee: SyntheZyme, LLCInventors: Jon E. Ness, Jeremy Minshull
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Publication number: 20130131222Abstract: The present invention relates to polyurethane polymers comprising as part of its polymer backbone biobased ?-hydroxyfatty acids or derivatives thereof, processes for the preparation thereof, and compositions thereof having improved properties. The polyurethanes of the present invention are prepared from copolyester prepolymers comprising the biobased ?-hydroxyfatty acids that may also contain additional components that can be selected from aliphatic or aromatic diacids, diols and hydroxyacids obtained from synthetic and natural sources. The biobased ?-hydroxyfatty acids that comprise the polyurethanes and copolyester prepolymers of the present invention are made using a fermentation process from pure fatty acids, fatty acid mixtures, pure fatty acid ester, mixtures of fatty acid esters, and triglycerides from various sources.Type: ApplicationFiled: March 11, 2011Publication date: May 23, 2013Applicant: SyntheZyme LLCInventor: Richard A. Gross