Patents Assigned to SyntheZyme LLC
  • Patent number: 9650405
    Abstract: A method for the development of a library of modified sophorolipids using a wide-range of chemical and enzyme catalyst tools to identify modified sophorolipids that can be used in pure form, as mixtures with other modified sophorolipids, as mixtures with natural sophorolipids, as mixtures with modified and natural sophorolipids, and as mixtures with other compounds known by one skilled in the art for use in the dispersion, solubilization or emulsification of various oil types and nutraceuticals, and modified sophorolipids for use in dispersion, solubilization or emulsification processes.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: May 16, 2017
    Assignee: Synthezyme, LLC
    Inventors: Richard A. Gross, Thavasi Rengathavasi, Amanda Koh, Yifeng Peng
  • Patent number: 9359581
    Abstract: A substantially pure Candida host cell is provided for the biotransformation of a substrate to a product wherein the host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt at least one alcohol dehydrogenase gene in the substantially pure Candida host cell.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: June 7, 2016
    Assignee: Synthezyme LLC
    Inventors: Jon E. Ness, Jeremy Minshull
  • Publication number: 20150225759
    Abstract: A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.
    Type: Application
    Filed: April 20, 2015
    Publication date: August 13, 2015
    Applicant: Synthezyme LLC
    Inventors: Richard A. Gross, Vishal Shah, Frantisek Nerud, Datta Madamwars
  • Publication number: 20150218486
    Abstract: An ?-carboxyl-?-hydroxyl fatty acid oxidized from a substantially pure Candida host cell, wherein the substantially pure Candida host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt an alcohol dehydrogenase gene, and a second genetic modification class, wherein the second genetic modification class comprises an insertion of a first gene into the Candida host cell genome.
    Type: Application
    Filed: April 6, 2015
    Publication date: August 6, 2015
    Applicant: SYNTHEZYME LLC
    Inventors: JON E. NESS, JEREMY MINSHULL
  • Patent number: 9051347
    Abstract: A composition of matter comprising sophorolipids as antimicrobial agents, antifungal agents, biopesticides, for uses as drugs to treat HIV, septic shock, cancer, asthma, dermatological conditions, as spermicidal agents, as anti-inflammatory drugs, as ingredients in cosmetics and building blocks for monomers and polymers and self-assembled templates for further chemical elaboration.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: June 9, 2015
    Assignee: Synthezyme, LLC
    Inventors: Richard A. Gross, Mark H. Schofield
  • Patent number: 9012194
    Abstract: A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: April 21, 2015
    Assignee: Synthezyme LLC
    Inventors: Richard A. Gross, Vishal Shah, Frantisek Nerud, Datta Madamwars
  • Patent number: 8796228
    Abstract: 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octa-decenoate, lactonic and open ring 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, methyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, hexyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6?-acetate and ethyl 17-L-[(2?-O-?-D-glucopyranosyl-?-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6?,6?-diacetate sophorolipids and uses thereof as antifungal agents.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: August 5, 2014
    Assignee: Synthezyme, LLC
    Inventors: Richard A. Gross, Vishal Shah
  • Publication number: 20140051780
    Abstract: The present invention relates to aliphatic or aliphatic-aromatic polyesters and copolyesters comprised of biobased ?-hydroxyfatty acids or derivatives thereof, processes for the preparation thereof, and compositions thereof having improved properties. The copolyesters of the present invention may also contain additional components that can be selected from aliphatic or aromatic diacids, diols and hydroxyacids obtained from synthetic and natural sources. The biobased ?-hydroxyfatty acids that comprise the polyesters and copolyesters of the present invention are made using a fermentation process from pure fatty acids, fatty acid mixtures, pure fatty acid ester, mixtures of fatty acid esters, and triglycerides from various sources. The polyesters of the present invention may contain various amounts and types of ?-carboxyfatty acids depending on the engineered yeast strain used for the bioconversion as well as the feedstock(s) used.
    Type: Application
    Filed: August 16, 2012
    Publication date: February 20, 2014
    Applicant: SyntheZyme LLC
    Inventor: Richard A. Gross
  • Patent number: 8648055
    Abstract: A method for neutralizing or inactivating a virus, and neutralizing or inactivating HIV using sophorolipids having antiviral properties produced by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as an antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an antiviral agent, and sophorolipid compounds for use as antiviral agents.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: February 11, 2014
    Assignee: SyntheZyme, LLC
    Inventors: Richard A Gross, Vishal Shah, Gustavo Doncel
  • Patent number: 8597923
    Abstract: A substantially pure Candida host cell is provided for the biotransformation of a substrate to a product wherein the host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt at least one alcohol dehydrogenase gene in the substantially pure Candida host cell.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: December 3, 2013
    Assignee: SyntheZyme, LLC
    Inventors: Jon E. Ness, Jeremy Minshull
  • Publication number: 20130131222
    Abstract: The present invention relates to polyurethane polymers comprising as part of its polymer backbone biobased ?-hydroxyfatty acids or derivatives thereof, processes for the preparation thereof, and compositions thereof having improved properties. The polyurethanes of the present invention are prepared from copolyester prepolymers comprising the biobased ?-hydroxyfatty acids that may also contain additional components that can be selected from aliphatic or aromatic diacids, diols and hydroxyacids obtained from synthetic and natural sources. The biobased ?-hydroxyfatty acids that comprise the polyurethanes and copolyester prepolymers of the present invention are made using a fermentation process from pure fatty acids, fatty acid mixtures, pure fatty acid ester, mixtures of fatty acid esters, and triglycerides from various sources.
    Type: Application
    Filed: March 11, 2011
    Publication date: May 23, 2013
    Applicant: SyntheZyme LLC
    Inventor: Richard A. Gross