Patents Assigned to Synthon IP Inc.
  • Extended release venlafaxine besylate tablets
    Patent number: 7776358
    Abstract: Venlafaxine besylate is formulated into an extended release tablet in high loading rates by use of a coating that contains ammonio methacrylate copolymer(s).
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: August 17, 2010
    Assignee: Synthon IP Inc.
    Inventors: Joan Cucala Escoi, Montserrat Gallego Luengo, Inocencia Margallo Lana
  • Processes for making pioglitazone and compounds of the processes
    Patent number: 7541470
    Abstract: Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
    Type: Grant
    Filed: February 19, 2005
    Date of Patent: June 2, 2009
    Assignee: Synthon IP Inc.
    Inventors: Jie Zhu, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7501517
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 10, 2009
    Assignee: Synthon IP, Inc.
    Inventors: Arjanne Overeem, Reinerus G. Gieling, Jie Zhu, Lambertus Thijs
  • Process for making desvenlafaxine
    Patent number: 7491848
    Abstract: Desvenlafaxine is formed from venlafaxine by the use of a demethylating agent comprising a metal sulfide, such as sodium sulfide, and optionally selenium.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: February 17, 2009
    Assignee: Synthon IP Inc.
    Inventors: Karel Pospisilik, Lambertus Thijs
  • Process for making risperidone and intermediates therefor
    Patent number: 7405298
    Abstract: The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: July 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Pavel Slanina, Jiri Bartl
  • Pramipexole acid addition salts
    Patent number: 7365086
    Abstract: The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: April 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus T. H. van Eupen, Frantisek Picha
  • Modified calcium phosphate excipient
    Patent number: 7364755
    Abstract: Calcium phosphate modified with a fatty acid wax in a weight ratio of 50:50 to 95:5, respectively, is useful as an excipient.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: April 29, 2008
    Assignee: Synthon IP Inc.
    Inventors: Joan Cucala Escoi, Montserrat Gallego Luengo, Arturo Siles Ortega
  • Amlodipine free base
    Patent number: 7335380
    Abstract: Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: February 26, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker, Rolf Keltjens
  • Synthesis of olanzapine and intermediates thereof
    Patent number: 7329747
    Abstract: Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: February 12, 2008
    Assignee: Synthon IP Inc.
    Inventors: Rolf Keltjens, Theodorus H. A. Peters
  • Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same
    Patent number: 7230016
    Abstract: Water-soluble salts of pioglitazone especially pioglitazone sulfate are useful in pharmaceutical applications.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: June 12, 2007
    Assignee: Synthon IP Inc.
    Inventors: Jie Zhu, Frantisek Picha
  • Process for making cabergoline
    Patent number: 7217822
    Abstract: A process for making cabergoline uses silyl-protecting agents to protect the indole nitrogen atom.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: May 15, 2007
    Assignee: Synthon IP Inc.
    Inventors: Jorge Humberto Zenon Comin, Gustavo Ariel Revelli, Fernando Gabriel Bardi
  • Amide derivative of amlodipine
    Patent number: 7199247
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: April 3, 2007
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for making bicalutamide and intermediates thereof
    Patent number: 7186854
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: March 6, 2007
    Assignee: Synthon IP Inc.
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit J. B. Ettema
  • Amide derivative of amlodipine
    Patent number: 7115638
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: October 3, 2006
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for making ondansetron and intermediates thereof
    Patent number: 7041834
    Abstract: A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a water binding agent. The reaction product(s) can be reacted with an amine of formula (5) to form ondansetron.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: May 9, 2006
    Assignee: Synthon IP Inc.
    Inventors: Dusan Hesoun, Jiri Hykl
  • Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
    Patent number: 6965051
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: November 15, 2005
    Assignee: Synthon IP Inc.
    Inventors: Hans J. Hoorn, Theodorus H. A. Peters, Jaroslav Pis, Radim Scigel